Fetal Renal Artery Doppler in Patients With Preeclampsia

NCT06395974 | Completed

• 1 other identifier: Fetal renal a./preeclampsia
• Study Type: observational
• Target: 114
• Locations: 1 country
• Sites: 1

Brief Summary

Preeclampsia is a major devastating disorder affects 2:10% of pregnancies worldwide. preeclampsia may be associated with placental insufficiency which may cause fetal blood redistribution to essential organs like brain, heart, kidney.

Conditions

Preeclampsia

Outcome Measures

Primary Outcomes (2)

• fetal renal artery doppler indices

  the difference between the Fetal renal artery Doppler indices between preeclamptic patients and women with healthy pregnancy

  1 year

• Middle cerberal artery doppler indices , Umbilical artery doppler indices and placental volume

  1 year

Secondary Outcomes (1)

• neonatal outcome

  1 year

Study Arms (2)

preeclampsia

Other: fetal ultrasound

control

Other: fetal ultrasound

Interventions

fetal ultrasound OTHER

2D, 3D , Doppler ultrasound

control; preeclampsia

Eligibility Criteria

• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

pregnant women with preeclampsia and healthy pregnant women

You may qualify if:

• a) Preeclampsia:
• Women with preeclampsia \>28 weeks of pregnancy.
• Singleton pregnancy.
• Women with intrauterine growth restriction and abnormal amniotic fluid volume to simulate real world data.
• b) Control:
• Women with healthy pregnancy matched by closest gestational age.

You may not qualify if:

• ● Multiple pregnancy.
• Known Congenital fetal malformations.
• Women with other comorbidity such as ischemic heart disease, DM, Autoimmune disorders, kidney disease, neurological disorders, liver or haematological disorders.
• Women unable to provide informed consent.
• Women who refuse to participate

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut university hospital

Asyut, Egypt

Location

Related Publications (10)

• Filipek A, Jurewicz E. [Preeclampsia - a disease of pregnant women]. Postepy Biochem. 2018 Dec 29;64(4):232-229. doi: 10.18388/pb.2018_146. Polish.

  PMID: 30656917 BACKGROUND

• Mou AD, Barman Z, Hasan M, Miah R, Hafsa JM, Das Trisha A, Ali N. Prevalence of preeclampsia and the associated risk factors among pregnant women in Bangladesh. Sci Rep. 2021 Oct 29;11(1):21339. doi: 10.1038/s41598-021-00839-w.

  PMID: 34716385 BACKGROUND

• Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circ Res. 2019 Mar 29;124(7):1094-1112. doi: 10.1161/CIRCRESAHA.118.313276.

  PMID: 30920918 BACKGROUND

• Stigter RH, Mulder EJ, Bruinse HW, Visser GH. Doppler studies on the fetal renal artery in the severely growth-restricted fetus. Ultrasound Obstet Gynecol. 2001 Aug;18(2):141-5. doi: 10.1046/j.1469-0705.2001.00493.x.

  PMID: 11529994 BACKGROUND

• Suranyi A, Streitman K, Pal A, Nyari T, Retz C, Foidart JM, Schaaps JP, Kovacs L. Fetal renal artery flow and renal echogenicity in the chronically hypoxic state. Pediatr Nephrol. 2000 May;14(5):393-9. doi: 10.1007/s004670050781.

  PMID: 10805467 BACKGROUND

• Nicolaides K, Giuseppe R, Hecher K, Ximenes R. Doppler in Obstetrics. ISUOG Educational Series, The Fetal Medicine Foundation, 2022.

  BACKGROUND

• Ma'ayeh M, Krishnan V, Gee SE, Russo J, Shellhaas C, Rood KM. Fetal renal artery impedance in pregnancies affected by preeclampsia. J Perinat Med. 2020 Mar 14:/j/jpme.ahead-of-print/jpm-2020-0024/jpm-2020-0024.xml. doi: 10.1515/jpm-2020-0024. Online ahead of print.

  PMID: 32171001 BACKGROUND

• Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222. Obstet Gynecol. 2020 Jun;135(6):e237-e260. doi: 10.1097/AOG.0000000000003891.

  PMID: 32443079 BACKGROUND

• Azpurua H, Dulay AT, Buhimschi IA, Bahtiyar MO, Funai E, Abdel-Razeq SS, Luo G, Bhandari V, Copel JA, Buhimschi CS. Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth. Am J Obstet Gynecol. 2009 Feb;200(2):203.e1-11. doi: 10.1016/j.ajog.2008.11.001.

  PMID: 19185102 BACKGROUND

• Magee LA, Nicolaides KH, von Dadelszen P. Preeclampsia. N Engl J Med. 2022 May 12;386(19):1817-1832. doi: 10.1056/NEJMra2109523. No abstract available.

  PMID: 35544388 BACKGROUND

MeSH Terms

Conditions

Pre-Eclampsia

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Yousra O Mokhtar

  principle investigator

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: April 29, 2024
• First Posted: May 2, 2024
• Study Start: November 1, 2024
• Primary Completion: December 30, 2025
• Study Completion: February 15, 2026
• Last Updated: May 11, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)