Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest

NCT07020091 | Active Not Recruiting

• 2 other identifiers: GAZI-494-ROSC-2025GAZI-ROSC-494-2025
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study aims to identify early predictors of in-hospital mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest. The study prospectively enrolls patients admitted to the intensive care unit at a tertiary care hospital in Turkey. Various clinical, biochemical, and resuscitation-related parameters will be recorded within the first 24 hours of ICU admission. The primary goal is to determine which factors are most strongly associated with mortality within 30 days. The findings are expected to improve clinical decision-making and risk stratification in the management of post-cardiac arrest patients.

Conditions

Post-Resuscitation Syndrome; Critical Illness; Cardiac Arrest; Hypoxic-Ischemic Encephalopathy; Coma

Keywords

Cardiac Arrest; ROSC; In-Hospital Mortality; ICU; Post-Resuscitation Care; Neurological Outcome

Outcome Measures

Primary Outcomes (2)

• In-Hospital Mortality

  All-cause mortality recorded during the index hospital stay following return of spontaneous circulation (ROSC).

  From ICU admission to hospital discharge (up to 60 days)

• 6-Month Mortality

  All-cause mortality assessed at 6 months following the initial cardiac arrest event. Mortality status is confirmed through hospital records and national death registry.

  6 months after ICU admission

Study Arms (1)

ROSC Cohort

Adult patients (≥18 years old) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the intensive care unit. These patients are prospectively followed to evaluate clinical and biochemical predictors of in-hospital mortality.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (≥18 years old) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the intensive care unit (ICU) at Gazi Yaşargil Training and Research Hospital, Turkey. Patients are consecutively enrolled and observed for outcomes related to in-hospital and 6-month mortality.

You may qualify if:

• Age ≥ 18 years
• Achieved return of spontaneous circulation (ROSC) after cardiac arrest
• Admitted to the intensive care unit (ICU)
• Informed consent obtained from patient or legal representative (if applicable)

You may not qualify if:

• Age \< 18 years
• Known pregnancy
• Brain death at the time of ICU admission
• Patients with missing key clinical or laboratory data
• Declined participation or legal refusal

Sponsors & Collaborators

• Ahmet Düzgün: lead

Study Sites (1)

Gazi Yaşargil Training and Research Hospital

Diyarbakır, kayapinar, 21070, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Critical Illness; Heart Arrest; Hypoxia-Ischemia, Brain; Coma

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Heart Diseases; Cardiovascular Diseases; Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hypoxia, Brain; Vascular Diseases; Hypoxia; Signs and Symptoms, Respiratory; Signs and Symptoms; Unconsciousness; Consciousness Disorders; Neurobehavioral Manifestations; Neurologic Manifestations

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Specialist in Internal Medicine and Intensive Care

Study Record Dates

• First Submitted: June 5, 2025
• First Posted: June 13, 2025
• Study Start: January 1, 2024
• Primary Completion: December 31, 2025
• Study Completion: March 31, 2026
• Last Updated: June 18, 2025

Record last verified: 2025-06

Locations

TU (1)