Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest

NCT07020091 | Completed Results

• 2 other identifiers: GAZI-494-ROSC-2025GAZI-ROSC-494-2025
• Study Type: observational
• Target: 168
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective observational cohort study aims to identify early predictors of short- and mid-term mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest. Eligible patients admitted to the intensive care unit between January 1, 2024 and May 31, 2025 were identified retrospectively from electronic medical records following institutional ethics approval. Clinical, biochemical, and resuscitation-related parameters recorded within the first 24 hours of ICU admission were analyzed. The primary objective was to determine factors independently associated with short-term mortality. Six-month mortality was additionally assessed using hospital records and the national death registry. The findings are expected to improve risk stratification and clinical decision-making in post-cardiac arrest care.

Conditions

Post-Resuscitation Syndrome; Critical Illness; Cardiac Arrest; Hypoxic-Ischemic Encephalopathy; Coma

Keywords

Cardiac Arrest; ROSC; In-Hospital Mortality; ICU; Post-Resuscitation Care; Neurological Outcome

Outcome Measures

Primary Outcomes (1)

• 30-Day Mortality

  All-cause mortality within 30 days of ICU admission following ROSC.

  30 days after ICU admission

Secondary Outcomes (2)

• In-Hospital Mortality

  From ICU admission to hospital discharge (up to 60 days)

• 6-Month Mortality

  6 months after ICU admission

Study Arms (1)

ROSC Cohort

Adult patients (≥18 years old) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the intensive care unit. These patients are prospectively followed to evaluate clinical and biochemical predictors of in-hospital mortality.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (≥18 years old) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the intensive care unit (ICU) at Gazi Yaşargil Training and Research Hospital, Turkey. Patients are consecutively enrolled and observed for outcomes related to in-hospital and 6-month mortality.

You may qualify if:

• Age ≥ 18 years
• Achieved return of spontaneous circulation (ROSC) after cardiac arrest
• Admitted to the intensive care unit (ICU)
• Informed consent obtained from patient or legal representative (if applicable)

You may not qualify if:

• Age \< 18 years
• Known pregnancy
• Brain death at the time of ICU admission
• Patients with missing key clinical or laboratory data
• Declined participation or legal refusal

Sponsors & Collaborators

• Ahmet Düzgün: lead

Study Sites (1)

Gazi Yaşargil Training and Research Hospital

Diyarbakır, Kayapinar, 21070, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Critical Illness; Heart Arrest; Hypoxia-Ischemia, Brain; Coma

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Heart Diseases; Cardiovascular Diseases; Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hypoxia, Brain; Vascular Diseases; Hypoxia; Signs and Symptoms, Respiratory; Signs and Symptoms; Unconsciousness; Consciousness Disorders; Neurobehavioral Manifestations; Neurologic Manifestations

Limitations and Caveats

This study is limited by its retrospective single-center design. Adverse events were not systematically collected. Residual confounding cannot be excluded.

Results Point of Contact

• Title: Ahmet Duzgun, MD, Intensive Care Specialist
• Organization: Department of Intensive Care, University of Health Sciences, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey

a.duzgun47@gmail.com

+90 544 674 5460

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Specialist in Internal Medicine and Intensive Care

Study Record Dates

• First Submitted: June 5, 2025
• First Posted: June 13, 2025
• Study Start: May 1, 2024
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: May 8, 2026
• Results First Posted: May 8, 2026

Record last verified: 2026-04

Locations

TU (1)