Outcome of Cardiac Arrest Patients Following Guidelines Implementation Over the Years

NCT06608771 | Recruiting

• 1 other identifier: 5033
• Study Type: observational
• Target: 693
• Locations: 1 country
• Sites: 2

Brief Summary

The study aims to evaluate the level of local implementation of the new interventions introduced by the guidelines for post-cardiac arrest management and their impact on the survival of patients resuscitated from cardiac arrest and admitted to intensive care over a 14-year period. During this time period, the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) introduced three new guidelines for post-cardiac arrest management, each five years apart: the 2010, 2015, and 2021 guidelines.

Conditions

Cardiac Arrest

Keywords

Out-Of-Hospital Cardiac Arrest; In-Hospital Cardiac Arrest; Guidelines Implementation; Resuscitation

Outcome Measures

Primary Outcomes (2)

• Intensive Care Unit (ICU) Survival

  To evaluate ICU survival for patients resuscitated from cardiac arrest

  From cardiac arrest date to ICU discharge or death, up to 90 days

• Neurological recovery at ICU discharge

  ICU Survival with Cerebral Performance Category (CPC) score of 1 or 2

  From cardiac arrest date to ICU discharge or death, up to 90 days

Secondary Outcomes (1)

• Hospital discharge status

  From cardiac arrest date to hospital discharge or death, up to 180 days

Study Arms (1)

Out-of-hospital cardiac arrest (OHCA) and In-hospital cardiac arrest (IHCA) patients

The study population includes all adult patients resuscitated from cardiac arrest and subsequently admitted to the Intensive Care Unit over a 14-year-period

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All adult patients resuscitated from cardiac arrest and admitted to ICU over a 14-year-period

You may qualify if:

• Patients resuscitated from cardiac arrest and admitted to intensive care unit
• Age ≥ 18 years
• Out-of-hospital and in-hospital cardiac arrest
• Cardiac arrest of any etiology

You may not qualify if:

• Pediatric patients (\<18 years)
• Patients not admitted to one of the aforementioned intensive care units.

Sponsors & Collaborators

• Mauro Panigada: lead

Study Sites (2)

Fondazione IRCCS San Gerardo dei Tintori

Monza, Monza E Brianza, 20900, Italy

RECRUITING

IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy

RECRUITING

MeSH Terms

Conditions

Heart Arrest; Out-of-Hospital Cardiac Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Giuseppe Ristagno, MD, PhD

  IRCCS Cà Granda Ospedale Maggiore Policlinico

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Giuseppe Ristagno, MD, PhD

CONTACT

+390255033258; giuseppe.ristagno@unimi.it

Mauro Panigada, MD

CONTACT

+390255033258; mauro.panigada@policlinico.mi.it

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Medical Doctor, Head of the Intensive Care Unit, Department of Anaesthesia, Intensive Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan

Study Record Dates

• First Submitted: August 8, 2024
• First Posted: September 23, 2024
• Study Start: July 26, 2024
• Primary Completion: December 31, 2025
• Study Completion: March 30, 2026
• Last Updated: September 23, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

IT (2)