Monitoring After Cardiac Arrest: Electroencephalogram and Cerebral Oximetry in Predicting Outcome

NCT06460480 | Completed

• 1 other identifier: 159-2023
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

Because of its high incidence, it is essential to determine the neurological prognosis after cardiac arrest. However, there is not much information to guide post-cardiac arrest care. Also, dynamic monitoring of the state of the brain can help provide information about the patient's prognosis other than previously described serum biomarkers. Therefore, the researchers will monitor postcardiac arrest patients in the intensive care unit for 48 hours by electroencephalogram and cerebral oximetry and collect blood samples for serum biomarkers: neuron-specific enolase (NSE), human neurogranin (NRGN) and human trigger receptor expressed on myeloid cells (TREM-2), which are associated with neuronal damage. And investigate the relation of these data to mortality.

Conditions

Cardiac Arrest; EEG With Periodic Abnormalities; Hypoxic-Ischemic Encephalopathy

Keywords

post-cardiac arrest; electroencephalogram; cerebral oxymetry; biomarkers; brain injury

Outcome Measures

Primary Outcomes (2)

• early mortality

  the status of the patient as exitus or alive within seven days post cardiac arrest

  from the first day of intensive care admission after cardiac resuscitation until seven days

• late mortality

  the status of the patient as exitus or alive within twenty eight days post cardiac arrest

  from the first day of intensive care admission after cardiac resuscitation until twenty eight days

Secondary Outcomes (3)

• supression ratio

  from the first hour of intensive care admission until 48 hour

• oxyhemoglobin deoxyhemoglobin ratio

  from the first hour of intensive care admission until 48 hour

• serum biomarkers

  post-cardiac arrest 24th hour

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged 18 years and older who have experienced cardiac arrest and whose permanent spontaneous circulation is maintained for at least 48 hours after CPR

You may qualify if:

• experienced cardiac arrest
• permanent spontaneous circulation is maintained for at least 48 hours after CPR
• immediate intensive care follow-up after cardiac resuscitation

You may not qualify if:

• Patients under 18 years of age
• Presence of previously known neurological disease (cerebral palsy, neurodegenerative disease, encephalitis, etc.)
• Immunosuppressive patients due to previously known hematological malignancy or solid tumor
• Patients with a history of head trauma
• Patients with cardiac arrest within 48 hours after spontaneous circulation is established
• Patients sedated for more than 24 hours

Sponsors & Collaborators

• Haseki Training and Research Hospital: lead

Study Sites (1)

Haseki Training and Research Hospital

Istanbul, Sultangazi, 34000, Turkey (Türkiye)

Location

Related Publications (3)

• El-Seify M, Shata MO, Salaheldin S, Bawady S, Rezk AR. Evaluation of Serum Biomarkers and Electroencephalogram to Determine Survival Outcomes in Pediatric Post-Cardiac-Arrest Patients. Children (Basel). 2023 Jan 18;10(2):180. doi: 10.3390/children10020180.

  PMID: 36832309 BACKGROUND

• Calderone A, Jarry S, Couture EJ, Brassard P, Beaubien-Souligny W, Momeni M, Liszkowski M, Lamarche Y, Shaaban-Ali M, Matta B, Rochon A, Lebon JS, Ayoub C, Martins MR, Courbe A, Deschamps A, Denault AY. Early Detection and Correction of Cerebral Desaturation With Noninvasive Oxy-Hemoglobin, Deoxy-Hemoglobin, and Total Hemoglobin in Cardiac Surgery: A Case Series. Anesth Analg. 2022 Dec 1;135(6):1304-1314. doi: 10.1213/ANE.0000000000006155. Epub 2022 Nov 16.

  PMID: 36097147 BACKGROUND

• Dilmen OK, Meco BC, Evered LA, Radtke FM. Postoperative neurocognitive disorders: A clinical guide. J Clin Anesth. 2024 Feb;92:111320. doi: 10.1016/j.jclinane.2023.111320. Epub 2023 Nov 8.

  PMID: 37944401 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

2 ml blood samples will be collected during routine intensive care sampling, centrifuged, and gathered to study serum biomarkers of NSE, NRGN, and TREM-2.

MeSH Terms

Conditions

Heart Arrest; Hypoxia-Ischemia, Brain; Brain Injuries

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hypoxia, Brain; Vascular Diseases; Hypoxia; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Officials

• Berna Caliskan, MD

  Haseki Training and Research Hospital Anesthesiology and Reanimation Department

  STUDY DIRECTOR

• Muhammet Ali Gök

  Haseki Training and Research Hospital Anesthesiology and Reanimation Department

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 28 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 11, 2024
• First Posted: June 14, 2024
• Study Start: June 15, 2024
• Primary Completion: January 1, 2025
• Study Completion: January 1, 2025
• Last Updated: March 19, 2025

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)