Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Cardiac Arrest

NCT05606809 | Recruiting

• 1 other identifier: 2022-A01811-42
• Study Type: observational
• Target: 4,500
• Locations: 1 country
• Sites: 5

Brief Summary

Even in patients with successful return of spontaneous circulation (ROSC), outcome after cardiac arrest remains poor. The overall in-hospital survival rate widely varies both worldwide and across communities, from 1 to 4 folds according to circumstances of arrest and post-resuscitation interventions. Several studies have already shown that early interventions performed after ROSC, such as treatment of the cause, targeted temperature management, optimal hemodynamic management and extra-corporeal life support in selected patients, could improve the outcome in post-cardiac arrest patients. However, the decision process regarding the allocation of these resources, in parallel with the management of patients' proxies, remains a complex challenge for physicians facing these situations. Consequently, several prediction models and scores have been developed in order to stratify the risk of unfavorable outcome and to discriminate the best candidates for post-resuscitation interventions. Overall, several scores exist, but external validation are lacking and direct comparisons are needed to assess relative interest of scoring systems. Indeed, establishing the optimal scoring system is crucial, for optimal treatment allocation and appropriate information to relatives.

Conditions

Cardiac Arrest

Keywords

cardiac arrest; intensive care unit; mechanical ventilation

Outcome Measures

Primary Outcomes (1)

• Determination of Area Under Curve of Cerebral Admission Hospital Prognosis (CAHP) Score at intensive care unit admission

  Determination of AUC for CAHP score as compare to Utstein style criteria. CAHP score range from 0 to 300 with higher score indicates poorer prognosis

  Intensive Care Unit Admission (Usually 3 hours after cardiac arrest

Interventions

Calculation of early prognosis score DIAGNOSTIC_TEST

Early prognosis score will be calculated at intensive care unit admission for each patient based on clinical and biological values as required

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This is an observational, prospective, multicentric prognostic study. The study period is 3 years, and investigators plan to include 4500 patients in 20 ICUs in France. For all patients included, medical history, clinical data, paraclinical results and outcome (at hospital discharge and at 3 months, including modified Rankin score) will be prospectively collected by local investigator, according to an electronical CRF.

You may qualify if:

• all adult patients, major, admitted to intensive care after cardiac arrest (after both in and out-of hospital cardiac arrest),
• comatose (defined by Glasgow score ≤ 8) on admission,

You may not qualify if:

• cardiac arrest occurring intra-hospital,
• minor patient,
• major patient under guardianship,
• protected persons,

Sponsors & Collaborators

• AfterROSC: lead

Study Sites (5)

CHU Nantes

Nantes, Pays de Loire, France

RECRUITING

Hopital Jacques Cartier

Massy, France

RECRUITING

Clinique Ambroise Paré

Neuilly-sur-Seine, France

RECRUITING

APHP, Cochin

Paris, France

RECRUITING

CH Versailles

Versailles, France

RECRUITING

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Central Study Contacts

Jean Baptiste Lascarrou, MD, PhD

CONTACT

+33240087376; jeanbaptiste.lascarrou@chu-nantes.fr

Alain Cariou, MD, PhD

CONTACT

alain.cariou@aphp.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 31, 2022
• First Posted: November 7, 2022
• Study Start: November 2, 2022
• Primary Completion (Estimated): September 30, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: October 3, 2025

Record last verified: 2025-09

Locations

FR (5)