Discover In-Hospital Cardiac Arrest

NCT06207201 | Completed

• 1 other identifier: 2022-14602
• Study Type: observational
• Target: 1,050
• Locations: 1 country
• Sites: 1

Brief Summary

The Discover In-Hospital Cardiac Arrest (IHCA) study is a multicenter, prospective observational study aimed at better understanding variations in practice for the post-in-hospital cardiac arrest patient.

Conditions

Cardiac Arrest

Keywords

In-hospital cardiac arrest; Post-cardiac arrest

Outcome Measures

Primary Outcomes (3)

• Fever Incidence

  The incidence of fever from ROSC until 96 hours after ROSC among patients who remain comatose

  Up to 96-hours post cardiac arrest

• Multimodal Prognostication

  The use of at least two approaches for prognostication prior to withdrawal of care from ROSC until hospital discharge

  Up to 60 days post cardiac arrest

• Early Withdrawal of Care

  The withdrawal of care from ROSC until 72-hour after ROSC

  Up to 72-hours post cardiac arrest

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All adult index in-hospital cardiac arrests where ROSC is achieved for \> 6 hours and the patient is not transitioned to comfort care in the first 6 hours after ROSC.

You may qualify if:

• Adult (≥18 years old) patients
• Patients with a cardiac arrest (a lack of palpable pulse or perfusing cardiac activity) while admitted to the hospital
• Patients admitted to a ward (telemetry or non-telemetry) or an intensive care unit, or are admitted but still in the emergency department waiting for a hospital bed
• Patients who achieved return of spontaneous circulation (ROSC defined as \>20 minutes of sustained spontaneous circulation) OR initiated on extracorporeal membrane oxygenation (eCPR) with chest compressions ongoing
• Patients survived for 6 hours after ROSC

You may not qualify if:

• Cardiac arrest in non-inpatients (e.g. outpatients, visitors)
• Patients whose cardiopulmonary resuscitation (CPR) starts outside of the hospital
• Non-index arrests (arrests that are not the patient's first arrest during the hospital admission; this also excludes patients who were initially admitted for an out-of-hospital cardiac arrest)
• Patients suffering IHCA in the operating room (OR) or post anesthesia care unit (PACU)
• Patients with cardiac arrest after arriving to an emergency department (ED) but prior to being evaluated and admitted to the hospital
• Cardiac arrests lasting \<2 minutes (i.e. chest compressions performed \<2 minutes)
• Cardiac arrests where the patient is transitioned to comfort focused care within 6 hours of return of spontaneous circulation (ROSC)

Sponsors & Collaborators

• Montefiore Medical Center: lead
• Society of Critical Care Medicine: collaborator

Study Sites (1)

Montefiore Medical Center

The Bronx, New York, 10467, United States

Location

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Ari Moskowitz, MD, MPH

  Montefiore Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 60 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 20, 2023
• First Posted: January 16, 2024
• Study Start: October 16, 2023
• Primary Completion: May 30, 2024
• Study Completion: June 30, 2024
• Last Updated: November 14, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)