Nicotine and Cannabis Vape Labeling Experiment - Spring 2025

NCT06919276 | Enrolling By Invitation DMC

• 4 other identifiers: UP-23-00483/HS-19-006825K24DA0481605U54CA180905-125R01CA229617-06
• Study Type: interventional
• Target: 3,900
• Locations: 1 country
• Sites: 1

Brief Summary

This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm.

Conditions

Vaping; Adolescent; Electronic Cigarette Use; Nicotine; Cannabis

Keywords

vaping device; product labeling; use susceptibility; perceived harm; nicotine; cannabis

Outcome Measures

Primary Outcomes (4)

• Use Intention Susceptibility

  This 3-item self-report measure assesses participant interest in trying the vaping device in the future. A 4-level Likert scale is used: definitely not, probably not, probably yes, definitely yes.

  5 minutes

• Perceived Health Harms

  This 2-item self-report measure assesses participant perception of health harms and risks associated with using the vaping product. A 4-level Likert scale is used: definitely not, probably not, probably yes, definitely yes.

  5 minutes

• Anticipated Subjective Effects

  This 9-item self-report measure assesses anticipated subjective effects from using the vaping device. Participants will select all that apply.

  5 minutes

• Anticipated Impairment/Enhancement

  This 4-item self-report measure assesses participant anticipated enhancement or impairment effects on completing different activities due to using the vaping product. A 5-level Likert scale is used: definitely make it harder, probably make it harder, no effect, probably make it easier, definitely make it easier.

  5 minutes

Study Arms (21)

Mint - Labeling Condition 1

EXPERIMENTAL

Participants will view an image of a mint-colored and flavored vape with label condition 1.

Other: Vaping Device Labeling

Mint - Labeling Condition 2

EXPERIMENTAL

Participants will view an image of a mint-colored and flavored vape with label condition 2.

Other: Vaping Device Labeling

Mint - Labeling Condition 3

EXPERIMENTAL

Participants will view an image of a mint-colored and flavored vape with label condition 3.

Other: Vaping Device Labeling

Mint - Labeling Condition 4

EXPERIMENTAL

Participants will view an image of a mint-colored and flavored vape with label condition 4.

Other: Vaping Device Labeling

Mint - Labeling Condition 5

EXPERIMENTAL

Participants will view an image of a mint-colored and flavored vape with label condition 5.

Other: Vaping Device Labeling

Mint - Labeling Condition 6

EXPERIMENTAL

Participants will view an image of a mint-colored and flavored vape with label condition 6.

Other: Vaping Device Labeling

Mint - Labeling Condition 7

EXPERIMENTAL

Participants will view an image of a mint-colored and flavored vape with label condition 7.

Other: Vaping Device Labeling

Original - Labeling Condition 1

EXPERIMENTAL

Participants will view an image of a white colored and original vape with label condition 1.

Other: Vaping Device Labeling

Original - Labeling Condition 2

EXPERIMENTAL

Participants will view an image of a white colored and original vape with label condition 2.

Other: Vaping Device Labeling

Original - Labeling Condition 3

EXPERIMENTAL

Participants will view an image of a white colored and original vape with label condition 3.

Other: Vaping Device Labeling

Original - Labeling Condition 4

EXPERIMENTAL

Participants will view an image of a white colored and original vape with label condition 4.

Other: Vaping Device Labeling

Original - Labeling Condition 5

EXPERIMENTAL

Participants will view an image of a white colored and original vape with label condition 5.

Other: Vaping Device Labeling

Original - Labeling Condition 6

EXPERIMENTAL

Participants will view an image of a white colored and original vape with label condition 6.

Other: Vaping Device Labeling

Original - Labeling Condition 7

EXPERIMENTAL

Participants will view an image of a white colored and original vape with label condition 7.

Other: Vaping Device Labeling

Blueberry - Labeling Condition 1

EXPERIMENTAL

Participants will view an image of a blue-colored and blueberry flavored vape with label condition 1.

Other: Vaping Device Labeling

Blueberry - Labeling Condition 2

EXPERIMENTAL

Participants will view an image of a blue-colored and blueberry flavored vape with label condition 2.

Other: Vaping Device Labeling

Blueberry - Labeling Condition 3

EXPERIMENTAL

Participants will view an image of a blue-colored and blueberry flavored vape with label condition 3.

Other: Vaping Device Labeling

Blueberry - Labeling Condition 4

EXPERIMENTAL

Participants will view an image of a blue-colored and blueberry flavored vape with label condition 4.

Other: Vaping Device Labeling

Blueberry - Labeling Condition 5

EXPERIMENTAL

Participants will view an image of a blue-colored and blueberry flavored vape with label condition 5.

Other: Vaping Device Labeling

Blueberry - Labeling Condition 6

EXPERIMENTAL

Participants will view an image of a blue-colored and blueberry flavored vape with label condition 6.

Other: Vaping Device Labeling

Blueberry - Labeling Condition 7

EXPERIMENTAL

Participants will view an image of a blue-colored and blueberry flavored vape with label condition 1.

Other: Vaping Device Labeling

Interventions

Vaping Device Labeling OTHER

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented. The label conditions are: 1. plain (i.e., no labeling on device) 2. "contains THC" 3. "contains 80% THC" 4. "contains 80% THC - HIGH POTENCY" 5. "contains nicotine" 6. "contains 5% nicotine" 7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.

Blueberry - Labeling Condition 1; Blueberry - Labeling Condition 2; Blueberry - Labeling Condition 3; Blueberry - Labeling Condition 4; Blueberry - Labeling Condition 5; Blueberry - Labeling Condition 6; Blueberry - Labeling Condition 7; Mint - Labeling Condition 1; Mint - Labeling Condition 2; Mint - Labeling Condition 3; Mint - Labeling Condition 4; Mint - Labeling Condition 5; Mint - Labeling Condition 6; Mint - Labeling Condition 7; Original - Labeling Condition 1; Original - Labeling Condition 2; Original - Labeling Condition 3; Original - Labeling Condition 4; Original - Labeling Condition 5; Original - Labeling Condition 6; Original - Labeling Condition 7

Eligibility Criteria

• Age: 11 Years - 19 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Participants must be enrolled in a partnering high school.

You may not qualify if:

• Participants who cannot independently understand study consent and the study surveys are ineligible.

Sponsors & Collaborators

• University of Southern California: lead
• National Institute on Drug Abuse (NIDA): collaborator
• National Cancer Institute (NCI): collaborator

Study Sites (1)

University of Southern California

Los Angeles, California, 90032, United States

Location

MeSH Terms

Conditions

Vaping; Marijuana Abuse

Condition Hierarchy (Ancestors)

Smoking; Behavior; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: University Professor of Population & Public Health Sciences and Psychology

Model Details: Participants will be randomized to one of seven labeling conditions and one of three device colors/flavors.

Study Record Dates

• First Submitted: February 28, 2025
• First Posted: April 9, 2025
• Study Start: March 3, 2025
• Primary Completion: May 1, 2025
• Study Completion: June 1, 2025
• Last Updated: April 9, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)