Barriers to Optimal LDL-C Targets in Patients With Atherosclerotic Cardiovascular Disease

NCT06897566 | Completed

• 1 other identifier: MS1462021
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 2

Brief Summary

In the present cross-sectional observational study, the investigators aimed to:

• Evaluate the prevalence of achievement of LDL-C targets among a sample of Egyptian ASCVD patients.
• Attempt to unveil the potential barriers to achieve LDL-C goals in order to determine the appropriate corrective actions.

Conditions

Statin Adverse Reaction; LDL Level; Coronary Artery Disease

Keywords

coronary artery disease; LDL-C; statins; statin intolerance; statin associated muscle symptoms

Outcome Measures

Primary Outcomes (1)

• Prevalence of achievement of recommended LDL-C targets among patients with established ASCVD

  Recruited patients will be stratified according to the LDL-C levels into those \<55, \<70, \<100, \<130, and above. Patients in different LDL-C strata will be surveyed. Predictors for failure of achievement of LDL-C goals will be sought.

  Being a cross sectional study selectively recruiting patients with established indication for >6months, the study will accept a fasting lipid profile that was performed within 1 month from surveying the recruited patient.

Interventions

Fasting lipid profile DIAGNOSTIC_TEST

Recruited patients will be requested to provide data from their most recent fasting lipid profile

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with established ASCVD with indication for high-intensity statin for a period 6 months This includes patients with coronary artery disease, peripheral arterial disease, cerebrovascular disease.

You may qualify if:

• Patients presenting to cardiology department/ outpatient clinic.
• Established ASCVD and eligible for high intensity statins for at least six-months.
• Age between18-to-80y.

You may not qualify if:

• Refusal to participate in the survey.
• Recent diagnosis of ASCVD with indication to high intensity statins for a period \< six-months.
• Patients with medical limitation or contraindications to statins therapy.
• Patients with documented diagnosis of homozygous familial hypercholesterolemia.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (2)

Faculty of Medicine Cairo University

Cairo, Egypt

Location

Faculty of Medicine, Cairo University

Cairo, Egypt

Location

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 19, 2025
• First Posted: March 27, 2025
• Study Start: September 21, 2024
• Primary Completion: November 1, 2025
• Study Completion: November 1, 2025
• Last Updated: December 3, 2025

Record last verified: 2025-12

Locations

EG (2)