The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training With Eccentric Loading

NCT06856629 | Completed

• 2 other identifiers: BASEC2024-02223SNCTP000006261
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Decreasing workloads in strength training makes it more tolerable for a broad range of people. When designed as blood-flow restriction training, similar gains in strength and muscle mass are achieved compared to traditional training. Adding high training loads to blood-flow restriction training only in the eccentric phase (BFR-ECC) might achieve superior gains in muscle strength while still maximizing tolerability of the training stimuli. This study aims to investigate the acute physiological and perceptual response of blood-flow restriction training with eccentric loading in comparison to traditional eccentric training. The study recruits healthy individuals ≥ 18 years.

Conditions

Healthy

Keywords

Blood-flow restriction training; acute physiological response; eccentric training

Outcome Measures

Primary Outcomes (1)

• minute ventilation

  recorded with breath-by-breath analysis

  During the intervention (i.e., exercise) for 10 minutes

Secondary Outcomes (5)

• Other variables from breath-by-breath analysis

  During the intervention (i.e., exercise) for 10 minutes

• Rate of perceived exertion

  Immediately after the intervention (i.e., exercise)

• Near-infrared spectroscopy of the vastus lateralis

  During the intervention (i.e., exercise) for 10 minutes

• Delayed onset muscle soreness

  24, 48, and 72 hours after each of the intervention (i.e., exercise)

• Feasibility and tolerability

  After study completion (i.e., after the second study visit, up to 2 weeks)

Study Arms (2)

Eccentric blood-flow restriction trainig

EXPERIMENTAL

Other: Eccentric blood-flow restriction training

Eccentric free-flow training

ACTIVE COMPARATOR

Other: Eccentric free-flow training

Interventions

Eccentric blood-flow restriction training OTHER

Eccentric blood-flow restriction training

Eccentric blood-flow restriction trainig

Eccentric free-flow training OTHER

Eccentric free-flow training

Eccentric free-flow training

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinically Healthy

You may not qualify if:

• Physical or intellectual impairment precluding informed consent or protocol adherence
• Pain during exercise of any origin
• History of thromboembolic event in the lower extremity
• Known pregnancy (no testing is carried out)

Sponsors & Collaborators

• Dario Kohlbrenner: lead

Study Sites (1)

University of Zurich

Zurich, 8001, Switzerland

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Model Details: With random sequence allocation

Study Record Dates

• First Submitted: February 6, 2025
• First Posted: March 4, 2025
• Study Start: January 31, 2025
• Primary Completion: July 28, 2025
• Study Completion: July 28, 2025
• Last Updated: July 31, 2025

Record last verified: 2025-07

Locations

CH (1)