NCT06790693

Brief Summary

This study will evaluate the efficacy and safety of the combination of inavolisib plus a cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) and letrozole versus placebo plus a CDK4/6i and letrozole in the first-line setting in participants with endocrine-sensitive PIK3CA-mutated hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), advanced breast cancer (ABC).

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
450

participants targeted

Target at P50-P75 for phase_3 breast-cancer

Timeline
74mo left

Started Apr 2025

Typical duration for phase_3 breast-cancer

Geographic Reach
20 countries

226 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress15%
Apr 2025May 2032

First Submitted

Initial submission to the registry

January 14, 2025

Completed
10 days until next milestone

First Posted

Study publicly available on registry

January 24, 2025

Completed
3 months until next milestone

Study Start

First participant enrolled

April 9, 2025

Completed
7.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 30, 2032

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 30, 2032

Last Updated

May 4, 2026

Status Verified

May 1, 2026

Enrollment Period

7.1 years

First QC Date

January 14, 2025

Last Update Submit

May 1, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Progression-Free Survival (PFS)

    From randomization to the first occurrence of disease progression or death from any cause, whichever occurs first (up to 7 years)

Secondary Outcomes (13)

  • Overall Survival (OS)

    From randomization to death from any cause (up to 7 years)

  • Investigator-assessed Objective Response Rate (ORR)

    Up to 7 years

  • Investigator-assessed Duration of Response (DOR)

    From the first occurrence of a confirmed objective response to the first occurrence of disease progression or death from any cause, whichever occurs first (up to 7 years)

  • Investigator-assessed Clinical Benefit Rate (CBR)

    Up to 7 years

  • Time to Confirmed Deterioration (TTCD) in Pain

    From baseline until end of follow-up (up to 7 years)

  • +8 more secondary outcomes

Study Arms (2)

Inavolisib + Letrozole + CDK4/6i

EXPERIMENTAL

Participants will receive inavolisib, letrozole and CDK4/6i.

Drug: InavolisibDrug: CDK4/6iDrug: Letrozole

Placebo + Letrozole + CDK4/6i

PLACEBO COMPARATOR

Participants will receive placebo, letrozole and CDK4/6i.

Drug: PlaceboDrug: CDK4/6iDrug: Letrozole

Interventions

Participants will receive oral placebo QD.

Placebo + Letrozole + CDK4/6i

Participants will receive CDK4/6i on either Days 1-21 or Days 1-28 of each 28-day cycle.

Inavolisib + Letrozole + CDK4/6iPlacebo + Letrozole + CDK4/6i

Participants will receive oral letrozole QD.

Inavolisib + Letrozole + CDK4/6iPlacebo + Letrozole + CDK4/6i

Participants will receive oral inavolisib once daily (QD).

Also known as: GDC-0077, Itovebi
Inavolisib + Letrozole + CDK4/6i

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Women or men with histologically or cytologically confirmed carcinoma of the breast
  • Documented ER-positive and/or progesterone receptor-positive tumor according to American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines
  • Documented HER2-negative tumor according to ASCO/CAP guidelines
  • De-novo HR+ , HER2- ABC, or, alternatively, relapsed HR+ , HER2- ABC after at least 2 years of standard neoadjuvant/adjuvant endocrine therapy without disease progression during that treatment and disease-free interval of at least 1 year since the completion of that treatment
  • Participants who have bilateral breast cancers which are both HR-positive and HER2-negative
  • Confirmation of biomarker eligibility
  • Consent to provide fresh or archival tumor tissue specimen
  • Measurable disease per Response Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST v1.1)
  • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
  • Adequate hematologic and organ function within 14 days prior to initiation of study treatment

You may not qualify if:

  • Pregnant or breastfeeding, or intention of becoming pregnant during the study or within the time frame in which contraception is required
  • Metaplastic breast cancer
  • Any prior systemic therapy for locally advanced unresectable or metastatic breast cancer
  • Type 2 diabetes requiring ongoing systemic treatment at the time of study entry; or any history of Type 1 diabetes
  • Any history of leptomeningeal disease or carcinomatous meningitis
  • Known and untreated, or active CNS metastases. Participants with a history of treated CNS metastases are eligible
  • Active inflammatory or infectious conditions in either eye or history of idiopathic or autoimmune-associated uveitis in either eye
  • Symptomatic active lung disease
  • History of or active inflammatory bowel disease
  • Any active bowel inflammation
  • Prior hematopoietic stem cell or bone marrow transplantation
  • Treatment with strong cytochrome P450 (CYP) 3A4 inhibitors or strong CYP3A4 inducers within 4 weeks or 5 drug-elimination half-lives, prior to initiation of study treatment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (226)

The Dignity Health Cancer Institute

Phoenix, Arizona, 85004, United States

RECRUITING

Disney Family Cancer Center

Burbank, California, 91505, United States

RECRUITING

Scripps Health

La Jolla, California, 92040, United States

RECRUITING

Cancer and Blood Specialty Clinic

Los Alamitos, California, 90720, United States

RECRUITING

Ellison Institute of Technology

Los Angeles, California, 90064, United States

RECRUITING

Palo Alto Medical Foundation Research Center

Palo Alto, California, 94301, United States

RECRUITING

Kaiser Permanente - San Marcos

San Marcos, California, 92069, United States

RECRUITING

Palo Alto Medical Foundation Research Center

San Mateo, California, 94401, United States

RECRUITING

Palo Alto Medical Foundation Research Center

Sunnyvale, California, 94086, United States

RECRUITING

Cancer Specialists of North Florida - Jacksonville

Jacksonville, Florida, 32207, United States

RECRUITING

Tallahassee Memorial HealthCare

Tallahassee, Florida, 32308, United States

RECRUITING

Moffitt Cancer Center-McKinley Campus

Tampa, Florida, 33612, United States

RECRUITING

Cleveland Clinic Florida

Weston, Florida, 33331, United States

RECRUITING

Northwest Georgia Oncology Centers PC - Marietta

Marietta, Georgia, 30060, United States

RECRUITING

Cancer Care Specialists of Central Illinois

O'Fallon, Illinois, 62269, United States

RECRUITING

Springfield Clinic

Springfield, Illinois, 62702, United States

RECRUITING

Carle Cancer Center

Urbana, Illinois, 61801, United States

RECRUITING

Baptist Health Lexington

Lexington, Kentucky, 40503, United States

RECRUITING

Baptist Health Hamburg

Lexington, Kentucky, 40509, United States

RECRUITING

University of Kentucky - Markey Cancer Center

Lexington, Kentucky, 40536, United States

RECRUITING

University of Louisville Hospital

Louisville, Kentucky, 40202, United States

RECRUITING

Baptist Health Louisville

Louisville, Kentucky, 40207, United States

RECRUITING

Velocity Clinical Research

Annapolis, Maryland, 21401, United States

RECRUITING

University of Maryland

Baltimore, Maryland, 21201, United States

RECRUITING

Henry Ford Health System

Detroit, Michigan, 48202, United States

RECRUITING

Cancer & Hematology Centers of Western Michigan

Grand Rapids, Michigan, 49503, United States

RECRUITING

University of Minnesota Medical Center

Minneapolis, Minnesota, 55455, United States

RECRUITING

HCA Midwest Health

Kansas City, Missouri, 64132, United States

RECRUITING

Nebraska Cancer Specialists

Grand Island, Nebraska, 68803, United States

RECRUITING

Nebraska Cancer Specialists

Omaha, Nebraska, 68130-2042, United States

RECRUITING

Astera Cancer Care East Brunswick

East Brunswick, New Jersey, 08816, United States

RECRUITING

Summit Medical Group

Florham Park, New Jersey, 07932, United States

RECRUITING

The Blavatnik Family ? Chelsea Medical Center at Mount Sinai

New York, New York, 10011, United States

RECRUITING

Mount Sinai West

New York, New York, 10019, United States

RECRUITING

Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States

RECRUITING

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

RECRUITING

Fairview Hospital

Cleveland, Ohio, 44111, United States

RECRUITING

Cleveland Clinic Foundation

Cleveland, Ohio, 44915, United States

RECRUITING

Hillcrest Hospital

Mayfield Heights, Ohio, 44124, United States

RECRUITING

Providence Portland Medical Center

Portland, Oregon, 97213, United States

RECRUITING

Providence Oncology and Hematology Cancer Clinic - Westside;Investigation Drug Services Pharmacy

Portland, Oregon, 97225, United States

RECRUITING

UPMC Hillman Cancer Center - Magee-Women?s Hospital

Pittsburgh, Pennsylvania, 15213, United States

RECRUITING

Bon Secours - St. Francis Hospital

Greenville, South Carolina, 29607, United States

RECRUITING

West Cancer Center

Germantown, Tennessee, 38138, United States

RECRUITING

Vanderbilt University Medical Center

Nashville, Tennessee, 37204, United States

RECRUITING

Community Clinical Trials

Kingwood, Texas, 77339, United States

RECRUITING

Swedish Cancer Institute - Edmonds Campus

Edmonds, Washington, 98026, United States

RECRUITING

Providence Regional Cancer Partnership

Everett, Washington, 98201-1621, United States

RECRUITING

Swedish Cancer Institute - Issaquah

Seattle, Washington, 98104, United States

RECRUITING

Swedish Cancer Institute

Seattle, Washington, 98104, United States

RECRUITING

Northwest Medical Specialties

Tacoma, Washington, 98405, United States

RECRUITING

Centro Oncologico Korben

Caba, C1426AGE, Argentina

RECRUITING

Centro Médico Fleischer

Capital Federal, C1414, Argentina

RECRUITING

Hospital Privado Centro Medico de Cordoba

Córdoba, 5016, Argentina

RECRUITING

Instituto de Oncologia de Rosario

Rosario, S2013KZE, Argentina

RECRUITING

Centro Oncológico de Excelencia

San Juan, J5400, Argentina

RECRUITING

Royal North Shore Hospital

St Leonards, New South Wales, 2065, Australia

RECRUITING

Lyell McEwin Hospital

Elizabeth Vale, South Australia, 5112, Australia

RECRUITING

Crio - Centro Regional Integrado de Oncologia

Fortaleza, Ceará, 60336-232, Brazil

RECRUITING

Hospital Santa Rita de Cassia Vitoria

Vitória, Espírito Santo, 29043-260, Brazil

RECRUITING

Obras Sociais Irma Dulce - Osid

Salvador, Estado de Bahia, 40415-006, Brazil

RECRUITING

Hospital Araujo Jorge

Goiânia, Goiás, 74605-070, Brazil

RECRUITING

Centro de Oncologia de Alfenas

Alfenas, Minas Gerais, 37130-087, Brazil

RECRUITING

Hospital do Câncer de Londrina

Londrina, Paraná, 86015-520, Brazil

RECRUITING

Hospital do Cancer de Pernambuco - HCP

Recife, Pernambuco, 50040-000, Brazil

RECRUITING

Vencer Oncoclínica - Centro de Pesquisa do Piauí

Teresina, Piauí, 64049-200, Brazil

RECRUITING

Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90020-090, Brazil

RECRUITING

Hospital de Cancer de Barretos

Barretos, São Paulo, 14784-400, Brazil

RECRUITING

Instituto do Cancer do Estado de Sao Paulo - ICESP

São Paulo, São Paulo, 01246-000, Brazil

RECRUITING

Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda

São Paulo, São Paulo, 01317-001, Brazil

RECRUITING

Instituto Nacional de Cancer - INCa

Rio de Janeiro, 20560-120, Brazil

RECRUITING

Arthur J.E. Child Comprehensive Cancer Center

Calgary, Alberta, T2N 4C2, Canada

RECRUITING

Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada

RECRUITING

CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada

RECRUITING

The Moncton Hospital

Moncton, New Brunswick, E1C 6Z8, Canada

RECRUITING

The Ottawa Hospital Cancer Center

Ottawa, Ontario, K1H 8L6, Canada

RECRUITING

Sault Area Hospital

Sault Ste. Marie, Ontario, P6B 0A8, Canada

RECRUITING

Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada

RECRUITING

St. Joseph's Health Centre

Toronto, Ontario, M6R 1B5, Canada

RECRUITING

Centre Hospitalier de l'Universite de Montreal (CHUM)

Montreal, Quebec, H2X 0C1, Canada

RECRUITING

Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada

RECRUITING

Hôpital du Sacré-Coeur de Montreal

Montreal, Quebec, H4J 1C5, Canada

RECRUITING

Unité de Recherche Clinique du CISSS de Laurentides

Saint-Jérôme, Quebec, J7Z 2V4, Canada

RECRUITING

Xiangyang Central Hospital

Xiangyang, Hubei, 441106, China

RECRUITING

Peking Union Medical College Hospital

Beijing, 100032, China

RECRUITING

Hunan Cancer Hospital

Changsha, 410013, China

RECRUITING

West China Hospital of Sichuan University

Chengdu, 610041, China

RECRUITING

Sichuan Provincial People's Hospital

Chengdu, 610072, China

RECRUITING

Sun yat-sen University Cancer Center

Guangzhou, 510060, China

RECRUITING

Sun Yat-Sen University Cancer Center - Huangpu Campus

Guangzhou, China

RECRUITING

Zhejiang Cancer Hospital

Hangzhou, 310022, China

RECRUITING

Harbin Medical University Cancer Hospital

Harbin, 150081, China

RECRUITING

Jiangmen Central Hospital

Jiangmen, 529030, China

RECRUITING

Shandong Cancer Hospital

Jinan, 250117, China

RECRUITING

Jinhua municipal central hospital

Jinhua, 321083, China

RECRUITING

Yunnan Cancer Hospital

Kunming, 650118, China

RECRUITING

Guangxi Cancer Hospital of Guangxi Medical University

Nanning, 530021, China

RECRUITING

Shantou Center Hospital

Shantou, 515031, China

RECRUITING

Tianjin Cancer Hospital

Tianjin, 300000, China

RECRUITING

Tianjin Cancer hospital Airport hospital

Tianjin, 300300, China

RECRUITING

Xinjiang Medical University Cancer Hospital

Ürümqi, 830011, China

RECRUITING

The Second Affiliated Hospital of Xi'an Jiao Tong University

Xi'an, 710004, China

RECRUITING

Shanxi Provincial People's Hospital

Xi'an, 710068, China

RECRUITING

ICO Paul Papin

Angers, 49055, France

RECRUITING

Centre Oscar Lambret

Lille, 59020, France

RECRUITING

Centre Cancerologie Grand Montpellier

Montpellier, 34070, France

RECRUITING

INSTITUT CURIE_SITE PARIS - Service d'Oncologie Médicale.

Paris, 75005, France

RECRUITING

Centre CARIO - HPCA

Plérin, 22190, France

RECRUITING

Chu La Miletrie

Poitiers, 86021, France

RECRUITING

Centre Eugene Marquis

Rennes, 35042, France

RECRUITING

Centre Henri Becquerel

Rouen, 76038, France

RECRUITING

HOPITAL RENE HUGUENIN- Institut Curie

Saint-Cloud, 92211, France

RECRUITING

Ico Rene Gauducheau

Saint-Herblain, 44805, France

RECRUITING

Institut Universitaire de Cancer de Toulouse Oncopole

Toulouse, 31100, France

RECRUITING

Gustave Roussy

Villejuif, 94805, France

RECRUITING

St. Elisabeth Krankenhaus Köln GmbH

Cologne, 50935, Germany

RECRUITING

Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden

Dresden, 01307, Germany

RECRUITING

Universitätsklinikum Essen

Essen, 45122, Germany

RECRUITING

Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH

Essen, 45136, Germany

RECRUITING

Kooperatives Mammazentrum Hamburg Krankenhaus Jerusalem

Hamburg, 20357, Germany

RECRUITING

Medizinische Hochschule Zentrum Frauenheilkunde Abt.Gynäkologische Onkologie

Hanover, 30625, Germany

RECRUITING

Nationales Centrum für Tumorerkrankungen (NCT)

Heidelberg, 69120, Germany

RECRUITING

InVO - Institut für Versorgungsforschung in der Onkologie GbR

Koblenz, 56068, Germany

RECRUITING

Dres. Andreas Köhler und Roswitha Fuchs

Langen, 63225, Germany

RECRUITING

Universitätsklinikum Münster

Münster, 48149, Germany

RECRUITING

Klinikum Ernst von Bergmann

Potsdam, 14467, Germany

RECRUITING

Caritas-Krankenhaus St. Josef

Regensburg, 93053, Germany

RECRUITING

Caritas Klinik St. Theresia -Frauenklinik Brustzentrum

Saarbrücken, 66113, Germany

RECRUITING

Universitätsklinik Tübingen

Tübingen, 72076, Germany

RECRUITING

Universitätsklinikum Ulm Am Michelsberg

Ulm, 89075, Germany

RECRUITING

Az. Osp. G. Panico

Tricase (LE), Apulia, 73039, Italy

RECRUITING

A.O. S. Anna e San Sebastiano

Caserta, Campania, 81100, Italy

RECRUITING

A.O. Universitaria Federico II Di Napoli

Naples, Campania, 80131, Italy

RECRUITING

U.O.C. Oncologia Medica Senologica

Naples, Campania, 80131, Italy

RECRUITING

Policlinico S.Orsola-Malpighi

Bologna, Emilia-Romagna, 40138, Italy

RECRUITING

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola

Meldola, Emilia-Romagna, 47014, Italy

RECRUITING

A.O. Universitaria Policlinico Di Modena

Modena, Emilia-Romagna, 41100, Italy

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Rome, Lazio, 00168, Italy

RECRUITING

Asst Papa Giovanni XXIII

Bergamo, Lombardy, 24127, Italy

RECRUITING

Ospedale San Raffaele

Milan, Lombardy, 20132, Italy

RECRUITING

Irccs Istituto Nazionale Dei Tumori (Int)

Milan, Lombardy, 20133, Italy

RECRUITING

Istituto Clinico Humanitas

Rozzano, Lombardy, 20089, Italy

RECRUITING

Humanitas Centro Catanese Di Oncologia

Misterbianco (CT), Sicily, 95045, Italy

RECRUITING

Azienda Sanitaria dell'Alto Adige;U.O.C. Oncologia Medic

Bolzano, Trentino-Alto Adige, 39100, Italy

RECRUITING

Ospedale Civile - Livorno

Livorno, Tuscany, 57124, Italy

RECRUITING

University of Eastern Piedmont - Maggiore della Carità University Hospital

Novara, Umbria, 28100, Italy

RECRUITING

A.O. Santa Maria Terni

Terni, Umbria, 05100, Italy

RECRUITING

Chiba Cancer Center

Chiba, 260-8717, Japan

RECRUITING

Fukushima Medical University Hospital

Fukushima, 960-1295, Japan

RECRUITING

Hiroshima University Hospital

Hiroshima, 734-8551, Japan

RECRUITING

Hokkaido University Hospital

Hokkaido, 060-8648, Japan

RECRUITING

Kanagawa Cancer Center

Kanagawa, 241-8515, Japan

RECRUITING

Tokai University Hospital

Kanagawa, 259-1193, Japan

RECRUITING

Saitama Medical University International Medical Center

Saitama, 350-1298, Japan

RECRUITING

The Cancer Inst. Hosp. of JFCR

Tokyo, 135-8550, Japan

RECRUITING

Instituto Nacional De Cancerologia

Distrito Federal, Mexico CITY (federal District), 14000, Mexico

RECRUITING

Hospital General de Mexico

MexicoCiudad de México, Nuevo León, 6726, Mexico

RECRUITING

Hospital Zambrano Hellion TecSalud

Monterrey, Nuevo León, Mexico

RECRUITING

Centro de Investigacion y Tratamiento Integral del Cancer: CITI Cancer Oaxaca S.A de C.V.

Ciudad de Huajuapan de León, Oaxaca, 69007, Mexico

RECRUITING

Centro de Investigacion Clinica de Oaxaca

Oaxaca City, Oaxaca, 68020, Mexico

RECRUITING

Centro Estatal de Cancerologia de Chihuahua

Chihuahua City, 31000, Mexico

RECRUITING

Iem-Fucam

D.F., 04980, Mexico

RECRUITING

Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde

Guadalajara, 44280, Mexico

RECRUITING

Instytut "Centrum Zdrowia Matki Polki"

?ód?, 93-338, Poland

RECRUITING

Bialostockie Centrum Onkologii

Bialystok, 15-027, Poland

RECRUITING

Przychodnia Lekarska KOMED, Roman Karaszewski

Konin, 62-500, Poland

RECRUITING

Szpital Wojewódzki im. Miko?aja Kopernika

Koszalin, 75-581, Poland

RECRUITING

Szpital Miejski Specjalistyczny Narutowicza

Krakow, 31-202, Poland

WITHDRAWN

COZL Oddzial Onkologii Klinicznej z pododdzialem Chemioterapii Dziennej

Lublin, 20-090, Poland

RECRUITING

Wielkopolskie Centrum Onkologii im. Marii Sk?odowskiej-Curie

Późna, 61-866, Poland

RECRUITING

MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie

Rzeszów, 35-021, Poland

RECRUITING

Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad

Warsaw, 02-781, Poland

RECRUITING

Dolno?l?skie Centrum Onkologii

Wroc?aw, 53-413, Poland

RECRUITING

PanOncology Trials

San Juan, 00935, Puerto Rico

RECRUITING

Linksfield Oncology Inc.

Johannesburg, 2192, South Africa

RECRUITING

Abraham Oncology

Richards Bay, 3900, South Africa

RECRUITING

Wits Clinical Research

Soweto, 2013, South Africa

RECRUITING

Kyungpook National University Chilgok Hospital

Daegu, 41404, South Korea

RECRUITING

Soon Chun Hyang University Cheonan Hospital

Dongnam-gu, Cheonan-si, 31151, South Korea

RECRUITING

National Cancer Center

Goyang-si, 10408, South Korea

RECRUITING

Seoul National University Bundang Hospital

Seongnam-si, 463-707, South Korea

RECRUITING

Seoul National University Hospital

Seoul, 03080, South Korea

RECRUITING

Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea

RECRUITING

Asan Medical Center

Seoul, 05505, South Korea

RECRUITING

Gangnam Severance Hospital

Seoul, 06273, South Korea

RECRUITING

Samsung Medical Center

Seoul, 06351, South Korea

RECRUITING

Hospital General Universitario de Elche

Elche, Alicante, 03203, Spain

RECRUITING

ICO L'Hospitalet

L'Hospitalet de Llobregat, Barcelona, 08908, Spain

RECRUITING

Hospital de Navarra

Pamplona/iruña, Navarre, 31008, Spain

RECRUITING

Hospital de Basurto

Bilbao, Vizcaya, 48013, Spain

RECRUITING

Vall d'Hebron Institute of Oncology (VHIO), Barcelona

Barcelona, 08035, Spain

RECRUITING

Hospital Universitario de la Princesa

Madrid, 28006, Spain

RECRUITING

IOB Madrid Institute of Oncology Hospital Beata Maria Ana de Jesus;Unidad Central de Oncología Médica y de Investigación Oncológica

Madrid, 28007, Spain

RECRUITING

Hospital General Univ. Gregorio Maranon

Madrid, 28009, Spain

RECRUITING

Hospital Universitario Infanta Leonor

Madrid, 28031, Spain

RECRUITING

Hospital Universitario Clínico San Carlos

Madrid, 28040, Spain

RECRUITING

Hospital Universitario 12 De Octubre

Madrid, 28041, Spain

RECRUITING

Hospital Clinico Universitario Virgen de la Victoria;Servicio de Oncologia

Málaga, 29011, Spain

RECRUITING

Hospital Universitario Virgen del Rocio

Seville, 41013, Spain

RECRUITING

Fundacion Instituto Valenciano de Oncologia (IVO)

Valencia, 46009, Spain

RECRUITING

Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain

RECRUITING

Kantonsspital Baden Zentrum für Onkologie und Hämatologie

Baden, 5404, Switzerland

RECRUITING

Universitätsspital Basel

Basel, 4031, Switzerland

RECRUITING

CHUV

Lausanne, 1011, Switzerland

RECRUITING

Luzerner Kantonsspital

Lucerne, 6004, Switzerland

RECRUITING

Chia-Yi Christian Hospital

Chiayi City, 600566, Taiwan

RECRUITING

Taichung Veterans General Hospital

Taichung, 407219, Taiwan

RECRUITING

National Cheng Kung Uni Hospital

Tainan, 704, Taiwan

RECRUITING

National Taiwan Uni Hospital

Taipei, 100, Taiwan

RECRUITING

Koo Foundation Sun Yat-Sen Cancer Center

Taipei, 112019, Taiwan

RECRUITING

Taipei Veterans General Hospital

Taipei, 112201, Taiwan

RECRUITING

Abdurrahman Yurtarslan Onkoloji Training and Research Hospital

Ankara, 06200, Turkey (Türkiye)

RECRUITING

Ankara City Hospital

Ankara, 06800, Turkey (Türkiye)

RECRUITING

Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji

Bakirkoy / Istanbul, 34147, Turkey (Türkiye)

RECRUITING

Ba?c?lar Medipol Mega Üniversite Hastanesi

Istanbul, 34214, Turkey (Türkiye)

RECRUITING

Izmir Ataturk Training and Research Hospital

Izmir, 35360, Turkey (Türkiye)

RECRUITING

Mersin City Education and Research Hospital

Mersin, 33240, Turkey (Türkiye)

RECRUITING

Blackpool Victoria Hospital

Blackpool, FY3 8NR, United Kingdom

RECRUITING

Colchester General Hospital

Colchester, Essex, CO4 5JL, United Kingdom

RECRUITING

Western General Hospital

Edinburgh, EH4 2XU, United Kingdom

RECRUITING

Princess Alexandra Hospital

Harlow, CM20 1QX, United Kingdom

RECRUITING

St Bartholomew's Hospital

London, EC1M 6BQ, United Kingdom

RECRUITING

Royal Free Hospital

London, NW3 2QG, United Kingdom

RECRUITING

Mount Vernon & Watford Hospital Trust

Northwood, HA6 2RN, United Kingdom

RECRUITING

Churchill Hospital - Oxford Cancer & Haematology Centre

Oxford, OX3 7LE, United Kingdom

RECRUITING

Weston Park Hospital

Sheffield, S10 2SJ, United Kingdom

RECRUITING

MeSH Terms

Conditions

Breast Neoplasms

Interventions

inavolisibLetrozole

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

NitrilesOrganic ChemicalsTriazolesAzolesHeterocyclic Compounds, 1-RingHeterocyclic Compounds

Study Officials

  • Clinical Trials

    Hoffmann-La Roche

    STUDY DIRECTOR

Central Study Contacts

Reference Study ID Number: WO45654 https://forpatients.roche.com/

CONTACT

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 14, 2025

First Posted

January 24, 2025

Study Start

April 9, 2025

Primary Completion (Estimated)

May 30, 2032

Study Completion (Estimated)

May 30, 2032

Last Updated

May 4, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will share

For eligible studies, qualified researchers may request access to individual patient level clinical data. See Roche's commitment to transparency of clinical study information here: https://go.roche.com/data\_sharing

Locations