Success Metrics

Clinical Success Rate
66.7%

Based on 2 completed trials

Completion Rate
67%(2/3)
Active Trials
23(82%)
Results Posted
150%(3 trials)
Terminated
1(4%)

Phase Distribution

Ph phase_1
8
29%
Ph phase_3
4
14%
Ph phase_2
15
54%

Phase Distribution

8

Early Stage

15

Mid Stage

4

Late Stage

Phase Distribution27 total trials
Phase 1Safety & dosage
8(29.6%)
Phase 2Efficacy & side effects
15(55.6%)
Phase 3Large-scale testing
4(14.8%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

50.0%

2 of 4 finished

Non-Completion Rate

50.0%

2 ended early

Currently Active

23

trials recruiting

Total Trials

28

all time

Status Distribution
Active(24)
Completed(2)
Terminated(2)

Detailed Status

Recruiting17
Active, not recruiting6
Completed2
Withdrawn1
Terminated1
Not yet recruiting1

Development Timeline

Analytics

Development Status

Total Trials
28
Active
23
Success Rate
66.7%
Most Advanced
Phase 3

Trials by Phase

Phase 18 (29.6%)
Phase 215 (55.6%)
Phase 34 (14.8%)

Trials by Status

withdrawn14%
active_not_recruiting621%
recruiting1761%
terminated14%
completed27%
not_yet_recruiting14%

Recent Activity

Clinical Trials (28)

Showing 20 of 28 trialsScroll for more
NCT05646862Phase 3

A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy

Active Not Recruiting
NCT07287150Phase 2

A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer

Recruiting
NCT06790693Phase 3

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Recruiting
NCT05894239Phase 3

A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

Recruiting
NCT07054190Phase 2

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

Recruiting
NCT04929223Phase 1

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

Recruiting
NCT07347600

A Study to Evaluate the Effectiveness and Safety of Inavolisib in Participants With Endocrine-resistant, PIK3CA-mutated, Hormone Receptor-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer

Recruiting
NCT07405801Phase 2

A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

Recruiting
NCT06496568Phase 1

A Study Evaluating Single-agent Inavolisib, Inavolisib Plus Atezolizumab, and Inavolisib Plus Pembrolizumab in PIK3CA-Mutated Cancers

Recruiting
NCT04802759Phase 1

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

Recruiting
NCT07522697Phase 2

Inavolisib for PIK3CA Mutated Advanced Endometrial Cancer: MITO END-4

Not Yet Recruiting
NCT07368998Phase 2

To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer

Recruiting
NCT05862285Phase 3

A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study

Recruiting
NCT07144111Phase 1

A Study to Evaluate the Effect of Moderate or Severe Hepatic Impairment on the Pharmacokinetics (PK) of Inavolisib

Recruiting
NCT04589845Phase 2

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

Active Not Recruiting
NCT04486352Phase 1

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Recruiting
NCT04191499Phase 2

A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer

Active Not Recruiting
NCT03424005Phase 1

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

Recruiting
NCT03006172Phase 1

To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

Active Not Recruiting
NCT04931342Phase 2

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
28