Vessel Angles and Diameters in Stroke Disease

NCT06756724 | Completed

• 1 other identifier: 22-KAEK-198
• Study Type: observational
• Target: 128
• Locations: 1 country
• Sites: 1

Brief Summary

Retrospective analysis of internal carotid artery morphology on CT angiography images of patients with acute ischemic stroke.

Conditions

Stroke Not Otherwise Specified; Control Condition

Keywords

Ischemic stroke risk; Carotid artery bifurcation; Computed tomography angiography; Bifurcation angles; Vessel diameters; Carotid artery morphology

Outcome Measures

Primary Outcomes (2)

• Internal carotid artery angle (degree measure)

  The effect of angle degree change at the bifurcation point of the internal carotid artery on acute ischemic stroke

  1 week

• Internal carotid artery diameter (cm)

  Effect of internal carotid artery diameter (cm) on acute ischemic stroke.

  1 Week

Secondary Outcomes (1)

• Internal carotid artery angle and diameter

  1 Week

Study Arms (2)

Stroke

Individuals with acute ischemic stroke

Healthy

Individuals without any intracranial pathology

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Individuals applying to the Emergency Department of Tokat Gaziosmanpasa University Medical Faculty Hospital

You may qualify if:

• Our study included 66 healthy individuals for control group. The control group consisted of individuals without any pathology or ischemia, selected from patients who underwent brain CTA for headache but showed no structural lesions. Additionally, none of the control group had a history of stroke or evidence of prior ischemic stroke on MRI.

You may not qualify if:

• After excluding patients with plaques in the carotid arteries (CCA and ICA), systemic vascular disease, risk factors for cardiogenic stroke, cardioembolism, ischemic stroke due to vasculitis or drug use, and other uncommon causes of stroke, 62 ischemic stroke patients were included in the study.

Sponsors & Collaborators

• Tokat Gaziosmanpasa University: lead

Study Sites (1)

Tokat Gaziosmanpasa University

Tokat Province, Merkez, 60000, Turkey (Türkiye)

Location

Related Publications (4)

• Liu Y, Ni L, Wang C, Shi P, Yin L, Fu XY, Zhou HD. Association between internal carotid artery kinking and ischemic stroke: A population-based cross-sectional study. J Stroke Cerebrovasc Dis. 2023 Dec;32(12):107417. doi: 10.1016/j.jstrokecerebrovasdis.2023.107417. Epub 2023 Nov 2.

  PMID: 37924779 BACKGROUND

• Apaydin M, Cetinoglu K. Carotid angle in young stroke. Clin Imaging. 2021 Feb;70:10-17. doi: 10.1016/j.clinimag.2020.10.020. Epub 2020 Oct 13.

  PMID: 33120284 BACKGROUND

• Arora S, Chien JD, Cheng SC, Chun KA, Wintermark M. Optimal carotid artery coverage for carotid plaque CT-imaging in predicting ischemic stroke. J Neuroradiol. 2010 May;37(2):98-103. doi: 10.1016/j.neurad.2009.04.002. Epub 2009 Jul 1.

  PMID: 19573923 BACKGROUND

• Cui Y, Lv X, Wang F, Kong J, Zhao H, Ye Z, Si C, Pan L, Liu P, Wen J. Geometry of the Carotid Artery and Its Association With Pathologic Changes in a Chinese Population. Front Physiol. 2020 Jan 21;10:1628. doi: 10.3389/fphys.2019.01628. eCollection 2019.

  PMID: 32038300 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: December 21, 2024
• First Posted: January 3, 2025
• Study Start: September 25, 2022
• Primary Completion: June 30, 2024
• Study Completion: June 30, 2024
• Last Updated: January 3, 2025

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)