Vision and Proprioception Evaluation With Robotics After Stroke

NCT07254949 | Not Yet Recruiting

• 2 other identifiers: REB25-1170197953
• Study Type: observational
• Target: 425
• Locations: 1 country
• Sites: 2

Brief Summary

Stroke is highly prevalent in Canada and can lead to profound upper limb impairments in motor and sensory function, as well and vision. Clinical assessments for these functions often lack sensitivity making detecting impairments and tracking their recovery after stroke difficult. It is known that sensory function and vision interact to inform motor behaviours, yet how each of these modalities might contribute to motor impairments and subsequent recovery after stroke is undetermined. Using robotics to assess neurologic function after a stroke can be very beneficial, as they can measure on the scale of millimetres and milliseconds which can more easily detect subtle deficits in a persons function. Compared to current clinical tools, robotics offer greater objectivity and reliability, as they do not rely on the examiners clinical experience and/or impression. The use of robotics not only offers a more precise measurement, but robotics assessments can be completed in a relatively short amount of time, in comparison to some of the current clinical assessment tools, which can take along time to complete. In addition to robotics, collecting neuroimaging (MRI/CT) will allow us to relate our robotic and eye-tracking measures to neuroanatomical information about the person's stroke. With this data, we will assess how the brain changes post-stroke in relation to the recovery of motor, sensory and visual functions. This research will: 1) examine the relationship between visual and proprioceptive impairment on motor and eye movement behaviour over time after stroke, and 2) identify neuroanatomical correlates of visual, proprioceptive and sensory integrative dysfunction that impact motor recovery after stroke and examine the ability of regional damage and network disruption to predict recovery. Objectives:

1. 1.Determine the impact of visual field loss and visual neglect in stroke survivors with impaired movement over the first 6 months post-stroke.
2. 2.Identify the impact of Proprioceptive Impairment and Sensory Integration Impairment on recovery post-stroke using robotics and eye tracking.
3. 3.Understand the impact of damage to neuroanatomic structures involved in vision, proprioception and sensory integration on motor recovery using MRI after stroke.

Conditions

Stroke; Control Condition

Keywords

Stroke; Sensation; Movement; Vision; Robotics; Eye-Tracking; Imaging

Outcome Measures

Primary Outcomes (1)

• Visually Guided Reaching Score

  Enrolment to six-months post stroke

Other Outcomes (17)

• Visually Guided Reaching Score (no vision)

  Enrolment to six-months post stroke

• Proprioceptive Saccade task scores

  Enrolment to six-months post stroke

• Arm Movement Matching (vision)

  Enrolment to six-months post stroke

Study Arms (2)

Stroke

Stroke Participants - Individuals with first time stroke

Control

Control Participants - Individuals not suffering stroke or other neurological disorders

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

425 participants will be recruited for this study (225 stroke participants and 200 matched control participants who have not experienced a stroke). All participant will be aged 18 or older.

You may qualify if:

• years of age or older
• First clinical diagnosis of stroke
• No recent muscle skeletal injuries to the arms, neck, or back
• No history of other neurological disease/injury (Ie. MS, Parkinson's, Brain Tumour, etc.)
• Corrected vision 20/50 or better
• Able to follow multi-step commands.
• Living independently prior to stroke
• Can consent to participate in research
• years of age or older
• No history stroke, or Trans Ischemic Attack (TIA)
• No recent muscle skeletal injures to the arms, neck, or back
• No history of other neurological disease/ injury (Ie. MS, Parkinson's, Brain Tumour, etc)
• No pre-stroke history of eye movement disorders
• Corrected vision 20/50 or better
• Able to follow multi-step commands

You may not qualify if:

• Prior history of stroke/significant neurologic problem (e.g. Parkinson's)
• Symptomatic medical conditions that would interfere with participation (e.g. uncontrolled angina)
• Contraindications to Magnetic Resonance Imaging (MRI)
• Pre-stroke history of visual field/oculomotor abnormalities.

Sponsors & Collaborators

• Dr. Sean Dukelow: lead

Study Sites (2)

Carewest Dr. Vernon Fanning Centre

Calgary, Alberta, Canada

Location

Foothills Medical Centre

Calgary, Alberta, Canada

Location

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 19, 2025
• First Posted: November 28, 2025
• Study Start: January 1, 2026
• Primary Completion (Estimated): January 1, 2031
• Study Completion (Estimated): June 1, 2031
• Last Updated: November 28, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

CA (2)