NCT06745440

Brief Summary

The objective of this prospective observational registry is to study patients di-agnosed with infective endocarditis (IE) and to gather comprehensive long-term outcome data, including mortality rates and IE-related complications (e.g., thromboembolic events, (hospitalization for) heart failure, valve surgery and IE recurrence) at one, three-, and five-years post-enrollment. Additionally, the registry will document epidemiological characteristics, clinical presentation at baseline, biochemical and microbiological profiles, relevant comorbidities and risk factors, diagnostic strategies, and therapeutic interventions, including an-timicrobial therapy and surgical procedures.

Trial Health

65
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
300

participants targeted

Target at P75+ for all trials

Timeline
93mo left

Started Sep 2025

Longer than P75 for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress8%
Sep 2025Dec 2033

First Submitted

Initial submission to the registry

December 17, 2024

Completed
3 days until next milestone

First Posted

Study publicly available on registry

December 20, 2024

Completed
9 months until next milestone

Study Start

First participant enrolled

September 1, 2025

Completed
7.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2032

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2033

Last Updated

August 28, 2025

Status Verified

August 1, 2025

Enrollment Period

7.3 years

First QC Date

December 17, 2024

Last Update Submit

August 27, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Mortality

    5-years

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Infective endocarditis

\> 18 yo

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

MeSH Terms

Conditions

Endocarditis

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Central Study Contacts

Bram Roosens, MD, PhD.

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
5 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 17, 2024

First Posted

December 20, 2024

Study Start

September 1, 2025

Primary Completion (Estimated)

December 31, 2032

Study Completion (Estimated)

December 31, 2033

Last Updated

August 28, 2025

Record last verified: 2025-08