The Predictive Value of Lubricin in Patients With Infective Endocarditis

NCT06266741 | Enrolling By Invitation

• 1 other identifier: NCT093509350936
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The main goal of this study is to evaluate the predictability of the disease by measuring the serum lubricin levels in patients with infective endocarditis and in non-patients

Conditions

Infective Endocarditis

Keywords

Infective endocarditis; Lubricin; Glycoprotein; Procalcitonin

Outcome Measures

Primary Outcomes (1)

• Valve damage indicative sign in infective endocarditis

  Concentration of Lubricin parameter have a determinative role in patients with infective endocarditis

  through study completion, an average of 2 years

Study Arms (2)

Patients with infective endocarditis

Patients between the ages of 18-65 diagnosed with infective endocarditis according to the Duke criteria

Diagnostic Test: Lubricin

Patients without infective endocarditis

Patients between the ages of 18-65 without diagnosed with infective endocarditis according to the Duke criteria

Diagnostic Test: Lubricin

Interventions

Lubricin DIAGNOSTIC_TEST

Plasma lubricin levels can potentially serve as a biomarker in situations like endocardial injury and infection.

Patients with infective endocarditis; Patients without infective endocarditis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Along with 30 healthy individuals, 30 patients between the ages of 18 and 65 who meet the Duke criteria and do not receive antibiotic treatment due to infective endocarditis will be examined. Pregnant women will not be included in the study. During this examination, procalcitonin and lubricin values will be measured.

You may qualify if:

• The patient must be between 18 and 65 years old
• Patients diagnosed with infective endocarditis according to the Duke criteria

You may not qualify if:

• \- The patient being pregnant

Sponsors & Collaborators

• Aydin Adnan Menderes University: lead

Study Sites (1)

Sevil Gulasti

Aydin, Zafer, 09010, Turkey (Türkiye)

Location

Related Publications (5)

• Delgado V, Ajmone Marsan N, de Waha S, Bonaros N, Brida M, Burri H, Caselli S, Doenst T, Ederhy S, Erba PA, Foldager D, Fosbol EL, Kovac J, Mestres CA, Miller OI, Miro JM, Pazdernik M, Pizzi MN, Quintana E, Rasmussen TB, Ristic AD, Rodes-Cabau J, Sionis A, Zuhlke LJ, Borger MA; ESC Scientific Document Group. 2023 ESC Guidelines for the management of endocarditis. Eur Heart J. 2023 Oct 14;44(39):3948-4042. doi: 10.1093/eurheartj/ehad193. No abstract available.

  PMID: 37622656 BACKGROUND

• Rajani R, Klein JL. Infective endocarditis: A contemporary update. Clin Med (Lond). 2020 Jan;20(1):31-35. doi: 10.7861/clinmed.cme.20.1.1.

  PMID: 31941729 BACKGROUND

• Holland TL, Baddour LM, Bayer AS, Hoen B, Miro JM, Fowler VG Jr. Infective endocarditis. Nat Rev Dis Primers. 2016 Sep 1;2:16059. doi: 10.1038/nrdp.2016.59.

  PMID: 27582414 BACKGROUND

• Richendrfer H, Jay GD. Lubricin as a Therapeutic and Potential Biomarker in Sepsis. Crit Care Clin. 2020 Jan;36(1):55-67. doi: 10.1016/j.ccc.2019.08.005. Epub 2019 Oct 21.

  PMID: 31733682 BACKGROUND

• Solakyildirim K, Li Y, Bayer AS, Sullam PM, Xiong YQ, Lebrilla CB, Bensing BA. Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis. Glycobiology. 2021 Dec 18;31(11):1582-1595. doi: 10.1093/glycob/cwab095.

  PMID: 34459483 BACKGROUND

MeSH Terms

Conditions

Endocarditis; Jacobs syndrome

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: October 25, 2023
• First Posted: February 20, 2024
• Study Start: February 11, 2024
• Primary Completion: February 20, 2024
• Study Completion: February 20, 2026
• Last Updated: February 20, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP

Locations

TU (1)