Resistance Exercise Blood Flow Restriction

NCT06724458 | Completed

• 1 other identifier: BFRCL
• Study Type: interventional
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

The number of repetitions able to be performed during resistance exercise is impacted by the load an individual is working against. Heavier loads lead to less repetitions being performed and lighter loads lead to more repetitions being performed. As the load gets progressively lighter, it is hypothesized that oxygen availability becomes an important factor for performance of maximum repetitions. Peripheral blood flow occlusion using exercise specific blood flow occlusion cuffs can allow for oxygen availability to be controlled by altering the amount of blood able to get to working muscles. To date, no study has examined the effect of varying exercise loads, from heavy to light, on maximum repetitions able to be performed with and without blood flow occlusion.

Conditions

Skeletal Muscle Endurance

Outcome Measures

Primary Outcomes (1)

• Maximum knee extension repetitions

  total repetitions completed for each load condition

  From weeks two to three in the study

Secondary Outcomes (20)

• Maximum barbell curl repetitions

  From weeks two to three in the study

• Change in vastus lateralis oxygen saturation

  From weeks two to three in the study

• Correlation of muscle fiber size/type/distribution to maximum knee extension repetitions at 20% 1RM

  From weeks two to three in the study

• Correlation of mitochondrial content to maximum knee extension repetitions at 20% 1RM

  From weeks two to three in the study

• Correlation of capillary density to maximum knee extension repetitions at 20% 1RM

  From weeks two to three in the study

Study Arms (12)

80% knee extension/80% barbell curl 1RM

EXPERIMENTAL

The load will be set to 80% of 1RM for the knee extension and 80% 1RM for the barbell curl

Other: Resistance exercise

40% knee extension/70% barbell curl 1RM

EXPERIMENTAL

The load will be set to 40% of 1RM for the knee extension and 70% 1RM for the barbell curl

Other: Resistance exercise

30% knee extension/60% barbell curl 1RM

EXPERIMENTAL

The load will be set to 30% of 1RM for the knee extension and 60% 1RM for the barbell curl

Other: Resistance exercise

25% knee extension/55% barbell curl 1RM

EXPERIMENTAL

The load will be set to 25% of 1RM for the knee extension and 55% 1RM for the barbell curl

Other: Resistance exercise

20% knee extension/50% barbell curl 1RM

EXPERIMENTAL

The load will be set to 25% of 1RM for the knee extension and 50% 1RM for the barbell curl

Other: Resistance exercise

15% knee extension/45% barbell curl 1RM

EXPERIMENTAL

The load will be set to 15% of 1RM for the knee extension and 45% 1RM for the barbell curl

Other: Resistance exercise

80% knee extension/80% barbell curl 1RM both with blood flow occlusion

EXPERIMENTAL

The load will be set to 80% of 1RM for the knee extension and 80% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Other: Resistance exercise

40% knee extension/60% barbell curl 1RM both with blood flow occlusion

EXPERIMENTAL

The load will be set to 40% of 1RM for the knee extension and 60% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Other: Resistance exercise

30% knee extension/60% barbell curl 1RM both with blood flow occlusion

EXPERIMENTAL

The load will be set to 30% of 1RM for the knee extension and 60% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Other: Resistance exercise

25% knee extension/55% barbell curl 1RM both with blood flow occlusion

EXPERIMENTAL

The load will be set to 25% of 1RM for the knee extension and 55% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Other: Resistance exercise

20% knee extension/50% barbell curl 1RM both with blood flow occlusion

EXPERIMENTAL

The load will be set to 20% of 1RM for the knee extension and 50% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Other: Resistance exercise

15% knee extension/45% barbell curl 1RM both with blood flow occlusion

EXPERIMENTAL

The load will be set to 15% of 1RM for the knee extension and 45% 1RM for the barbell curl with both being under peripheral blood flow occlusion

Other: Resistance exercise

Interventions

Resistance exercise OTHER

All arms will involve participants performing resistance exercise bouts of the described exercises. at the given loads, and with the stated flow condition

15% knee extension/45% barbell curl 1RM; 15% knee extension/45% barbell curl 1RM both with blood flow occlusion; 20% knee extension/50% barbell curl 1RM; 20% knee extension/50% barbell curl 1RM both with blood flow occlusion; 25% knee extension/55% barbell curl 1RM; 25% knee extension/55% barbell curl 1RM both with blood flow occlusion; 30% knee extension/60% barbell curl 1RM; 30% knee extension/60% barbell curl 1RM both with blood flow occlusion; 40% knee extension/60% barbell curl 1RM both with blood flow occlusion; 40% knee extension/70% barbell curl 1RM; 80% knee extension/80% barbell curl 1RM; 80% knee extension/80% barbell curl 1RM both with blood flow occlusion

Eligibility Criteria

• Age: 19 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Able to understand and communicate in English
• years of age
• All "No" answers on the Canadian Society for Exercise Physiology Get Active questionnaire or doctors' approval to participate
• Untrained participants: no structured resistance and/or endurance training over the past 12-months (i.e., \>2 hours per week of structured/periodized training)
• Resistance trained participants: structured resistance training over the past 12-months (i.e., \>2 hours per week of structured/periodized resistance training)
• Endurance trained participants: structured resistance training over the past 12-months (i.e., \>2 hours per week of structured/periodized endurance training)

You may not qualify if:

• BMI lower than 18 or greater than 30
• Current use of cigarettes or other nicotine devices
• Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
• Any medical condition impacting the ability to participate in maximal exercise
• Type one or type two diabetes
• Diagnosis of cancer or undergoing cancer treatment in the past 12 months
• Taking blood-thinning medication or the presence of a bleeding disorder
• Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines)
• Lowest calculated exercise testing load is less than the lightest weight able to be provided by the lab gymnasium equipment (i.e., 36 pounds for the knee extension, and/or 33 pounds for the barbell curl)

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

Chan Gunn Pavilion

Vancouver, British Columbia, V6T 1Z3, Canada

Location

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 9, 2023
• First Posted: December 9, 2024
• Study Start: January 28, 2023
• Primary Completion: November 21, 2023
• Study Completion: November 21, 2023
• Last Updated: December 9, 2024

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)