Efficacy Comparison of Jarlsberg- and Norvegia Cheese on Bone Markers and Bone Mineral Density in Nordic Skiers

NCT06688032 | Completed DMC

• 1 other identifier: XCS-Jarlsberg/IIA
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The study objective consists of the following two aims:

1. 1.Compare the effect of daily intake of Jarlsberg and Norvegia cheese on bonehealth in active Cross Country- and Biathlon skiers of both sexes.
2. 2.Compare the effect daily intake of Jarlsberg and Norvegia cheese in change of the metabolism , Muscle Strength, Muscle Mass and endurace in active Cross Country- and Biathlon skiers of both sexes.

Conditions

Bone Health; Performance Enhancing Product Use

Keywords

XCS; Bone markers; Cheese; Muscle strength

Outcome Measures

Primary Outcomes (1)

• BMD

  Bone Mineral Density

  From baseline to 24 weeks

Study Arms (2)

Jarlsberg cheese

ACTIVE COMPARATOR

Daily oral intake of 75g and 90g Jarlsberg cheese to females and males, respectively

Other: Jarlsberg cheese

Norvegia cheese

ACTIVE COMPARATOR

Daily oral intake of 75g and 90g Norvegia cheese to females and males, respectively

Other: Norvegia

Interventions

Jarlsberg cheese OTHER

Jarlsberg cheese contains Propionebacterium freudenreichii (PF) producing the K2-vitamer MK-9(4H) and DHNA in addition to the K2-vitamers found in Norvegia cheese

Also known as: Oral daily intake of Jarlsberg cheese

Jarlsberg cheese

Norvegia OTHER

Cheese with different content of K2 vitamers

Also known as: Oral daily intake of Norvegia cheese

Norvegia cheese

Eligibility Criteria

• Age: 17 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Active Cross-country and Biathlon skiers from 17 years of age for females and 18 years for males.

You may not qualify if:

• Eating disorder
• Pregnancy
• Serious gastrointestinal disorder.
• Abnormal liver or kidney function.
• Diabetes
• Suffering from verified cancer.
• Under systemic treatment with corticosteroids or other immunosuppressive drugs the last 3 weeks before start of the trial treatment.
• Participating in another clinical trial with pharmaceuticals the last six weeks before start of this trial treatment.
• Known milk product allergy.
• Suffering from diseases or injuries that disable them to perform VO2 or muscular strength tests.
• Not able to understand information.
• Do not want or not able to give written consent to participate in the study.

Sponsors & Collaborators

• Meddoc: lead
• Norwegian School of Sport Sciences: collaborator

Study Sites (1)

Norwegian School of Sport sciences

Oslo, 0863, Norway

Location

Related Publications (1)

• Lundberg HE, Larsen S, Mathisen TF, Sundgot-Borgen J. Comparison of cheese with and without Propionibacterium freudenreichii subsp. shermanii LMGT 2951 on off-season muscle strength and VO2 max development in Nordic skiers: a randomized clinical trial. J Int Soc Sports Nutr. 2025 Dec;22(1):2566373. doi: 10.1080/15502783.2025.2566373. Epub 2025 Sep 30.

  PMID: 41025612 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Blinding was not possible due to the look and tast of the two cheeses
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor Emeritus

Model Details: Design and randomization The study was performed as an open randomized stratified parallel group designed trial with two strata. Sex is used as a stratification factor. The two equal sized strata are chosen because of different OED of cheese for women and men, and because the dose-response study previously performed has shown different response in men and women. The participants were equally allocated (1:1) to either Jarlsberg or Norvegia cheese by block randomization.

Study Record Dates

• First Submitted: November 12, 2024
• First Posted: November 14, 2024
• Study Start: April 17, 2023
• Primary Completion: October 15, 2023
• Study Completion: October 15, 2023
• Last Updated: November 18, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

NO (1)