The Effect of Repetitive Transcranial Magnetic Stimulation for Internet Gaming Disorder

NCT06634498 | Recruiting

• 1 other identifier: The effect of rTMS in IGD
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 2

Brief Summary

This study aims to investigate the intervention effects of navigated repetitive transcranial magnetic stimulation (rTMS) on craving regulation in individuals with internet gaming disorder (IGD). The primary objectives include: (1) examining the impact of navigated rTMS over the dorsolateral prefrontal cortex (DLPFC) on the gaming cravings, and craving regulation capacity; and (2) exploring the potential neural mechanisms by which rTMS over the DLPFC improves craving intensity, and craving regulation ability.

Conditions

Internet Gaming Disorder

Keywords

rTMS; Internet gaming disorder; craving; craving regulation

Outcome Measures

Primary Outcomes (3)

• Change in craving scores in the Cue-Reactivity(CR) task

  Comparing the participants who reported craving scores for the game stimuli in the unregulated condition and in the regulated condition in the CR task conducted separately during real rTMS and sham rTMS. Higher scores mean higher craving.

  Approximately 10 minutes during real rTMS condition and sham rTMS

• Changes in the DLPFC and craving-related brains (striatum, amygdala) activities in the ROC task following rTMS and sham rTMS

  This study will compare the changes in DLPFC activity during the ROC task after real rTMS and sham rTMS. In addition, craving-related brain regions (striatum and amygdala) are also concerned.

  Approximately 14 minutes - 29 minutes after real rTMS and sham rTMS

• Alterations in the functional connectivity between the DLPFC and other brain regions in the ROC task following rTMS and sham rTMS

  The present study compares the alterations in functional connectivity between the DLPFC and other brain regions (especially those related to reward) after real TMS and sham TMS.

  Approximately 14 minutes - 29 minutes after real rTMS and sham rTMS

Secondary Outcomes (3)

• Changes in ReHo and fALFF/ALFF in resting-state following rTMS and sham rTMS

  5 minutes-13 minutes after real rTMS and sham rTMS

• The DLPFC-based functional connectivity alterations during resting-state fMRI

  5 minutes-13 minutes after real rTMS and sham rTMS

• The intra- and inter-connectivity within brain networks during resting-state fMRI

  5 minutes-13 minutes after real rTMS and sham rTMS

Study Arms (2)

real rTMS on the dlPFC

EXPERIMENTAL

rTMS on the DLPFC Dorsolateral prefrontal cortex (DLPFC) target will be identified by the baseline functional magnetic resonance imaging (fMRI) study for regulation of craving using a separate sample. During the intervention, each participant will receive an iTBS mode intervention on this DLPFC region.

Other: real rTMS on the dlPFC

sham rTMS on the dlPFC

SHAM COMPARATOR

Each participant will also receive a sham rTMS intervention as a controlled condition.

Other: Sham (No Treatment)

Interventions

real rTMS on the dlPFC OTHER

During real rTM session, participants will perform the regulation of craving (ROC). In the rest phase, participants need to relax and rest. In the ROC task, participants will regulate craving elicited by gaming pictures using cognitive reappraisal. During the task, reaction times (RTs) and craving scores wil be recorded.

real rTMS on the dlPFC

Sham (No Treatment) OTHER

During the sham rTMS session, participants will perform the regulation of craving (ROC). In the ROC task, participants will regulate craving elicited by gaming pictures using cognitive reappraisal. During the task, reaction times (RTs) and craving scores wil be recorded.

sham rTMS on the dlPFC

Eligibility Criteria

• Age: 18 Years - 30 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• DSM-V gaming disorder \>5 and scored ≥ 50 on a revised version of Young's online Internet addiction test；
• spent more than 50% of their online time gaming；
• engagement in one of four popular Internet game (Arena of Valor,Genshine, LOL, FPS) for over 20 hours per week for at least 1 year.

You may not qualify if:

• current or history of use of illegal substances and gambling;
• current or history of psychiatric or neurological illness;
• current use of psychotropic medications;
• cognitive impairment as assessed by the Mini-International Neuropsychiatric Interview；
• surgery, head trauma or heart related diseases in the past year；
• a history of epilepsy or seizures or increased risk of seizures for any reason；
• metal implants or tattoos of the neck or head；
• claustrophobia.

Sponsors & Collaborators

• Jin-tao Zhang: lead
• Zi-Liang Wang, Medical Ethics Committee of Zhenjiang Mental Health Center: collaborator

Study Sites (2)

Medical Ethics Committee of Zhenjiang Mental Health Center

Zhenjiang, Jiangsu, China

RECRUITING

State Key Laboratory of Cognitive Neuroscience and Learning

Beijing, China

RECRUITING

MeSH Terms

Conditions

Internet Addiction Disorder

Interventions

salicylhydroxamic acid

Condition Hierarchy (Ancestors)

Technology Addiction; Behavior, Addictive; Compulsive Behavior; Impulsive Behavior; Behavior

Study Officials

• Jin-Tao Zhang, Phd

  Beijing Normal University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jin-Tao Zhang, Phd

CONTACT

15010233046; zhangjintao@bnu.edu.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: single blind: both participants and experiment won't know the stimulation condition
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Model Details: within-subject, sham-controlled design: all subjects will receive active and sham rTMS in a randomized order

Study Record Dates

• First Submitted: October 5, 2024
• First Posted: October 10, 2024
• Study Start: October 10, 2024
• Primary Completion: December 30, 2024
• Study Completion: June 30, 2025
• Last Updated: October 15, 2024

Record last verified: 2024-10

Locations

CN (2)