Cognitive Bias Modification Training on Internet Gaming Disorder

NCT03790527 | Unknown DMC

• 1 other identifier: IGD_CBM intervention
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate whether and how the CBM training will alleviate the symptoms of addiction in Internet gaming disorders.

Conditions

Internet Gaming Disorder

Outcome Measures

Primary Outcomes (4)

• Behavioral outcome

  Cognitive bias outside fMRI measured by AAT task takes the response times\[\[Push\_game\_pic-Pull\_game\_pic\]-\[Push\_object\_pic - Pull\_object\_pic\])\] as the index. The response times (cognitive bias scores) will be calculated under Repeated Measurement Anova by using SPSS software.

  60- 80 minutes after training

• Resting-state functional connectivity alterations in brain.

  Using seed-based and network level functional connectivity analysis, as well as graph theory analysis , functional connectivity in brain under eight minutes resting state will be detected and compared between CBM training group and sham group

  30-45 minutes after training

• task-based fMRI brain activation

  The active of the brain regions in mPFC and VS during AAT task changes after CBM training compared with the sham. There should be an decrease in ventral striatum and amygdala during the cue-induced task. These task-based fMRI data will be contrasted using SPM.

  45-60 minutes after training

• Correlation analysis

  The correlation between functional network organization in brain across resting state ( task-based fMRI) and cognitive bias scores will be explored.

  30- 60 minutes after training

Study Arms (2)

CBM training

EXPERIMENTAL

participants have to complete the picture assessment task ; Approach-avoidance Task(AAT) and cue-induced task in the fMRI；data on game-craving level, game hours, the ability of self-control and emotion regulation are also collected. Half of the participants will be random-assigned into the CBM training group; Each participant will do these task twice( e.g. Before training and after training)

Procedure: CBM training

Sham training

SHAM COMPARATOR

participants have to complete the picture assessment task ; Approach-avoidance Task(AAT) and cue-induced task in the fMRI；data on game-craving level, game hours, the ability of self-control and emotion regulation are also collected. Half of the participants will be random-assigned into the sham training group; Each participant will do these task twice( e.g. Before training and after training)

Procedure: Sham training

Interventions

CBM training PROCEDURE

participants will be random-assigned into one of training groups. Participants in the modification group will receive modified training of 400 trials for six sessions during six days, the same as the sham group.The difference between these two groups is the proportion of push/pull trials. The sequence of the interventions will be counterbalanced across participants, and the callback will be conduct after one week.

CBM training

Sham training PROCEDURE

participants will be random-assigned into one of training groups. Participants in the modification group will receive modified training of 400 trials for six sessions during six days, the same as the sham group.The difference between these two groups is the proportion of push/pull trials. The sequence of the interventions will be counterbalanced across participants, and the callback will be conduct after one week.

Sham training

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• , DSM-5 recommended diagnosis of Internet gaming disorder :
• the scores of the 9 items of DSM-5 recommended diagnosis for Internet gaming disorder ≥ 5.
• engagement in popular Internet games (e.g. Arena of Valor, League of Legends and Player Unknown's Battle Grounds) for over 20 hours per week for a minimum of 12 months.
• , the scores of the Y-IAT(Young-Internet addiction Test) ≥ 50

You may not qualify if:

• current or history of use of illegal substances and gambling;
• current or history of psychiatric or neurological illness;
• current use of psychotropic medications.

Sponsors & Collaborators

• Beijing Normal University: lead

Study Sites (1)

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University

Beijing, Beijing Municipality, 100875, China

RECRUITING

Related Publications (3)

• Wiers CE, Stelzel C, Gladwin TE, Park SQ, Pawelczack S, Gawron CK, Stuke H, Heinz A, Wiers RW, Rinck M, Lindenmeyer J, Walter H, Bermpohl F. Effects of cognitive bias modification training on neural alcohol cue reactivity in alcohol dependence. Am J Psychiatry. 2015 Apr;172(4):335-43. doi: 10.1176/appi.ajp.2014.13111495. Epub 2014 Dec 19.

  PMID: 25526597 BACKGROUND

• Wiers CE, Ludwig VU, Gladwin TE, Park SQ, Heinz A, Wiers RW, Rinck M, Lindenmeyer J, Walter H, Bermpohl F. Effects of cognitive bias modification training on neural signatures of alcohol approach tendencies in male alcohol-dependent patients. Addict Biol. 2015 Sep;20(5):990-9. doi: 10.1111/adb.12221. Epub 2015 Jan 13.

  PMID: 25639749 BACKGROUND

• Rinck M, Becker ES. Approach and avoidance in fear of spiders. J Behav Ther Exp Psychiatry. 2007 Jun;38(2):105-20. doi: 10.1016/j.jbtep.2006.10.001. Epub 2006 Nov 28.

  PMID: 17126289 BACKGROUND

MeSH Terms

Conditions

Internet Addiction Disorder

Condition Hierarchy (Ancestors)

Technology Addiction; Behavior, Addictive; Compulsive Behavior; Impulsive Behavior; Behavior

Study Officials

• Jin-Tao Zhang, PhD

  Beijing Normal University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Rui Wang, Master

CONTACT

+8618810315922; 851006286@qq.com

Jin-Tao Zhang, PhD

CONTACT

+8610 58800728; zhangjintao@bnu.edu.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: double blind: both participants and experimenters won't know which group is training group or sham control group.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associated Professor

Model Details: The investigators assigned subjects to two training groups and collected pre - and post-test data

Study Record Dates

• First Submitted: December 26, 2018
• First Posted: December 31, 2018
• Study Start: April 13, 2019
• Primary Completion: October 30, 2019
• Study Completion: December 30, 2019
• Last Updated: August 21, 2019

Record last verified: 2019-08

Locations

CN (1)