Respiratory Parameters Using Advanced Airways During In-hospital Cardiac Arrest

NCT06580652 | Recruiting

• 1 other identifier: 328233
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators aim to investigate the real life volumes of air delivered to the lungs when rescuers deliver these breaths by hand as part of resuscitation attempts during cardiac arrest. The study will compare the volumes achieved using different devices which are routinely used to provided an airway during routine cardiac arrest care. Volumes will be measured using a small non intrusive device which sits in the airway circuit and measures flow of air in real time. The patients chosen for this study will be those already recruited to an ongoing trial (AIRWAYS-3) assessing the outcomes for patients suffering in hospital cardiac arrest based on airway device used.

Conditions

Cardiac Arrest

Outcome Measures

Primary Outcomes (1)

• Tidal Volume

  The mean tidal volume achieved during cardiac arrest treatment

  assessed from the initiation of advanced airway management to the cessation of the resuscitation treatment (Return of spontaneous circulation or death). Through completion of data collection, ranging between minutes to 1 hour.

Secondary Outcomes (3)

• Mean leak

  assessed from the initiation of advanced airway management to the cessation of the resuscitation treatment (Return of spontaneous circulation or death). Through completion of data collection, ranging between minutes to 1 hour.

• inspiratory time

  assessed from the initiation of advanced airway management to the cessation of the resuscitation treatment (Return of spontaneous circulation or death). Through completion of data collection, ranging between minutes to 1 hour.

• Expiratory time

  assessed from the initiation of advanced airway management to the cessation of the resuscitation treatment (Return of spontaneous circulation or death). Through completion of data collection, ranging between minutes to 1 hour.

Other Outcomes (4)

• Respiratory rate

  assessed from the initiation of advanced airway management to the cessation of the resuscitation treatment (Return of spontaneous circulation or death). Through completion of data collection, ranging between minutes to 1 hour.

• Smallest tidal volume

  assessed from the initiation of advanced airway management to the cessation of the resuscitation treatment (Return of spontaneous circulation or death). Through completion of data collection, ranging between minutes to 1 hour.

• largest tidal volume

  assessed from the initiation of advanced airway management to the cessation of the resuscitation treatment (Return of spontaneous circulation or death). Through completion of data collection, ranging between minutes to 1 hour.

Study Arms (2)

Tracheal Tube

participants in cardiac arrest in whom a tracheal tube is used as the airway device

Supraglottic Airway

participants in cardiac arrest in whom a supraglottic airway is used as the airway device

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who have suffered a cardiac arrest whilst an in patient.

You may qualify if:

• As per AIRWAYS-3 trial:
• In-hospital cardiac arrest, attended by the hospital cardiac arrest team in response to a cardiac arrest call (2222 or equivalent), and when a clinician permitted to undertake both tracheal intubation and supraglottic airway placement (so that either intervention can be delivered) is present
• Undergoing resuscitation and requiring advanced airway management in the opinion of the trained clinician responsible for randomisation

You may not qualify if:

• As per AIRWAYS-3 trial
• Patients who have a cardiac arrest outside hospital and who are transported to the hospital in ongoing cardiac arrest
• People who are not a hospital inpatient (e.g. visitor, relative, staff or outpatient)
• Patients who are already tracheally intubated at the time of eligibility assessment
• Patients known to be pregnant
• Patients with a functioning tracheostomy

Sponsors & Collaborators

• Royal United Hospitals Bath NHS Foundation Trust: lead
• RCUK: collaborator

Study Sites (1)

Royal United Hospital Bath

Bath, Banes, BA13NG, United Kingdom

RECRUITING

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Kelly Spencer

  Royal United Hosptial Bath

  STUDY CHAIR

Central Study Contacts

James Penketh

CONTACT

07973504245; jpenketh@nhs.net

Jerry Nolan

CONTACT

jerry.nolan@nhs.net

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2024
• First Posted: August 30, 2024
• Study Start: August 28, 2024
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: November 21, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)