Intravascular Clotting (POCUS) - Marker of the Timing and Severity of Cardiac Arrest; Indicator of Futile Resuscitation

NCT06406920 | Recruiting

• 1 other identifier: 71-01423/K01/61/643/282/2024
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The scientific goals of the project:

1. 1.ultrasound assessment of the incidence of clotting in deep veins in patients after cardiac arrest during resuscitation and after the declaration of death; comparison to the incidence of clotting in the heart cavities
2. 2.comparison of resuscitation results in patients with and without clotting detected in deep veins during resuscitation
3. 3.determining the time from cardiac arrest to the occurrence of clotting in deep veins; comparison to the time until clotting occurs in the heart cavities

Conditions

Cardiac Arrest

Keywords

cardiopulmonary resuscitation CPR; point-of-care ultrasound POCUS; intravascular clotting

Outcome Measures

Primary Outcomes (4)

• Intravascular clotting during CPR

  The percentage of patients with intravascular clotting observed during cardioplumonary resuscitation.

  One year (preliminary data will be presented after 6 months.

• Intravascular clotting after termination of CPR

  The percentage of patients with intravascular clotting observed after termination of CPR

  One year (preliminary data will be presented after 6 months.

• Time from cardiac arrest to first clot during CPR

  Time from cardiac arrest to the first intravascular clot fromation during CPR

  One year (preliminary data will be presented after 6 months.

• Time from cardiac arrest to first clot after termination of CPR.

  Time from cardiac arrest to the first intravascular clot fromation after termination of CPR.

  One year (preliminary data will be presented after 6 months.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who experience cardiac arrest in the emergency department, regardless of the mechanism and cause. Patients who were declared dead after resuscitation after cardiac arrest that occurred in the emergency department

You may qualify if:

• patients who experience cardiac arrest in the emergency department, regardless of the mechanism and cause
• patients who were declared dead after resuscitation after cardiac arrest that occurred in the emergency department

You may not qualify if:

• age under 18 years

Sponsors & Collaborators

• Medical University of Gdansk: lead

Study Sites (1)

University Clinical Centre - Clinical Emergency Department

Gdansk, Pomeranian Voivodeship, 80-214, Poland

RECRUITING

Related Publications (6)

• Reynolds JC, Issa MS, C Nicholson T, Drennan IR, Berg KM, O'Neil BJ, Welsford M; Advanced Life Support Task Force of the International Liaison Committee on Resuscitation. Prognostication with point-of-care echocardiography during cardiac arrest: A systematic review. Resuscitation. 2020 Jul;152:56-68. doi: 10.1016/j.resuscitation.2020.05.004. Epub 2020 May 11.

  PMID: 32437781 BACKGROUND

• Jackowski C, Thali M, Aghayev E, Yen K, Sonnenschein M, Zwygart K, Dirnhofer R, Vock P. Postmortem imaging of blood and its characteristics using MSCT and MRI. Int J Legal Med. 2006 Jul;120(4):233-40. doi: 10.1007/s00414-005-0023-4. Epub 2005 Nov 19.

  PMID: 16328426 BACKGROUND

• Lau V, Blaszak M, Lam J, German M, Myslik F. Point-of-Care Resuscitative Echocardiography Diagnosis of Intracardiac Thrombus during cardiac arrest (PREDICT Study): A retrospective, observational cohort study. Resusc Plus. 2022 Mar 11;10:100218. doi: 10.1016/j.resplu.2022.100218. eCollection 2022 Jun.

  PMID: 35299826 BACKGROUND

• Clattenburg EJ, Wroe P, Brown S, Gardner K, Losonczy L, Singh A, Nagdev A. Point-of-care ultrasound use in patients with cardiac arrest is associated prolonged cardiopulmonary resuscitation pauses: A prospective cohort study. Resuscitation. 2018 Jan;122:65-68. doi: 10.1016/j.resuscitation.2017.11.056. Epub 2017 Nov 23.

  PMID: 29175356 BACKGROUND

• Scerrati A, Menegatti E, Zamboni M, Malagoni AM, Tessari M, Galeotti R, Zamboni P. Internal Jugular Vein Thrombosis: Etiology, Symptomatology, Diagnosis and Current Treatment. Diagnostics (Basel). 2021 Feb 23;11(2):378. doi: 10.3390/diagnostics11020378.

  PMID: 33672254 BACKGROUND

• Nolan JP, Berg RA, Andersen LW, Bhanji F, Chan PS, Donnino MW, Lim SH, Ma MH, Nadkarni VM, Starks MA, Perkins GD, Morley PT, Soar J; Utstein Collaborators. Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Template for In-Hospital Cardiac Arrest: A Consensus Report From a Task Force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia). Resuscitation. 2019 Nov;144:166-177. doi: 10.1016/j.resuscitation.2019.08.021. Epub 2019 Sep 16.

  PMID: 31536777 BACKGROUND

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Robert K Szymczak, Asst. Prof.

  Medical University of Gdansk, Department of Emergency Medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Robert K Szymczak, Asst. Prof.

CONTACT

0048667674141; robert.szymczak@gumed.edu.pl

Mariusz Siemiński, Professor

CONTACT

0048606292536; msieminski@uck.gda.pl

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 12 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 24, 2024
• First Posted: May 9, 2024
• Study Start: April 29, 2024
• Primary Completion: October 1, 2024
• Study Completion: April 1, 2025
• Last Updated: May 9, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

PL (1)