Arterial Blood Pressure and Cardiac Arrest

NCT06443567 | Withdrawn FDA Device

• 1 other identifier: B01830
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To describe and measure diastolic and systolic femoral arterial pressure during medical cardiac arrest. To define baseline measures. To describe and measure arterial blood pressure after placement of an ITD device. To observe the diastolic pressure immediately prior to return of spontaneous circulation. To quantify and describe the effects of intravenous adrenaline on arterial blood pressure in cardiac arrest.

Conditions

Cardiac Arrest

Keywords

impedance threshold device; blood pressure; cardiac arrest

Outcome Measures

Primary Outcomes (1)

• systolic femoral invasive blood pressure

  3 mins average with CPR by LUCAS device

Secondary Outcomes (2)

• femoral diastolic pressure

  3 mins average with CPR by LUCAS device

• femoral arterial pressure, both systolic and diastolic

  3 mins average post placement of ICD device

Study Arms (1)

adult cardiac arrest

blood pressure measurement pre and post impedance threshold device placement

Device: impedance threshold device

Interventions

impedance threshold device DEVICE

impedance threshold device (ResQPOD, Zoll) applied to airway

adult cardiac arrest

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (18+) suffering an out of hospital cardiac arrest (OHCA) by a presumed medical cause that have been deemed suitable to attempt resuscitation of. All individuals will be considered for inclusion in this study regardless of age, disability, gender reassignment, marriage, and civil partnership, pregnancy and maternity, race, religion and belief, sex, and sexual orientation except where the study inclusion and exclusion criteria EXPLICITLY state otherwise.

You may qualify if:

• Adult patients (≥18years) in medical cardiac arrest
• Deemed suitable to attempt resuscitation.

You may not qualify if:

• Prisoners
• \<18years
• Pregnancy
• Traumatic cardiac arrest
• Arrest caused by hypovolaemia, tension or tamponade as determined by the clinical team on scene
• Inability to secure a patent airway.

Sponsors & Collaborators

• Manchester University NHS Foundation Trust: lead
• North West Ambulance Service nhs foundation trust: collaborator

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 30, 2024
• First Posted: June 5, 2024
• Study Start: September 1, 2024
• Primary Completion: December 1, 2024
• Study Completion: June 1, 2025
• Last Updated: September 25, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share