Consuming Grass Finished Lamb Improves Blood Plasma ω-3 Fatty Acid Response Among Healthy Consumers.

NCT06607354 | Completed

• 1 other identifier: 19.08v2
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the impact of consuming grass-finished lamb meat on blood omega-3 PUFAs and cardiovascular risk factors compared to concentrate-finished lamb meat. Healthy volunteers will consume three portions of lamb meat/week from a grass-finished meat treatment or a concentrate-finished meat treatment for four weeks. Blood samples will be taken at weeks zero and four. The primary outcome is to assess difference in change in omega-3 PUFA concentration in plasma and platelets between treatment groups. The secondary outcome is to assess between groups differences in change in cardiovascular disease risk factors including blood pressure, BMI and lipids among healthy individuals.

Conditions

Healthy

Keywords

Lamb; Omega-3; Fatty acids; Plasma; Plasma phospholipids

Outcome Measures

Primary Outcomes (2)

• Fatty acid (%) change in blood plasma between treatments

  Primary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood plasma response in healthy volunteers

  Week 0 and week 4

• Fatty acid change (%) in blood plasma phospholipids between treatments

  Primary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood plasma phospholipid response in healthy volunteers

  Week 0 and week 4

Secondary Outcomes (4)

• Change in weight (kg) in participants between treatments

  Week 0 and week 4

• Change in Body Mass Index (BMI) in participants between treatments - calculated by dividing weight (kg) by height in meters squared

  Week 0 and week 4

• Cholesterol

  Week 0 and week 4

• Blood pressure (diastolic and systolic)

  Week 0 and week 4

Study Arms (2)

Concentrate/ Cereal fed lamb

NO INTERVENTION

Participants to consume three portions of lamb per week for four consecutive weeks. The lamb diet was a concentrate/cereal pellet.

Grass fed lamb

EXPERIMENTAL

Participants to consume three portions of lamb per week for four consecutive weeks. The lamb diet was grass only.

Other: Grass fed lamb

Interventions

Grass fed lamb OTHER

This study investigated the impact of consuming grass finished lamb on total blood plasma and blood plasma phospholipids (PL) FA and on cardiovascular risk factors, including heart rate, blood pressure (BP), HDL-cholesterol, LDL-cholesterol, and TAG cholesterol, in humans.

Grass fed lamb

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy male and female volunteers aged between 18-64 years old.

You may not qualify if:

• Participants with a BMI of \<18.5 km/m² and greater than \>35 km/m².
• Participants who take prescribed medication, including statins to reduce LDL cholesterol, and any form of dietary supplements (excluding vitamin D).
• People who smoke.
• Participants who consume more than two portions of fish per month.

Sponsors & Collaborators

• Queen's University, Belfast: lead
• Agri-Food and Biosciences Institute: collaborator

Study Sites (1)

School of Biological Sciences, Queen's University Belfast

Belfast, BT9 5DL, United Kingdom

Location

Related Publications (1)

• Perkins LS, Nugent AP, Woodside JV, Cardwell CR, Scollan ND. Consuming grass finished lamb improves blood plasma omega-3 fatty acid response among healthy consumers. Eur J Nutr. 2025 Jul 21;64(5):242. doi: 10.1007/s00394-025-03765-z.

  PMID: 40690019 DERIVED

Study Officials

• Nigel D Scollan, PhD

  Queen's University, Belfast

  PRINCIPAL INVESTIGATOR

• Jayne V Woodside, PhD

  Queen's University, Belfast

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Describe it was the participant
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Postdoctoral Researcher

Model Details: Describe parallel arms

Study Record Dates

• First Submitted: September 9, 2024
• First Posted: September 23, 2024
• Study Start: June 20, 2019
• Primary Completion: December 13, 2019
• Study Completion: December 13, 2019
• Last Updated: September 24, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)