Physical Activity Guarantees Bone Density.

NCT06606769 | Recruiting

• 2 other identifiers: RO_NdS_MNiSW2024NdS-II/SP/0364/2023/01
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Bone tissue is crucial for overall health and quality of life, but it undergoes constant internal remodeling, leading to osteoporosis, a widespread bone disease. Regular physical activity can improve bone mineral density (BMD) and prevent osteoporosis. Studies have shown that premenopausal women with regular physical activity have greater BMD. Diagnosing bone resorption is essential, and dual-energy X-ray absorptiometry tests (DXA) and circulating microRNAs (miRNAs) may offer more prognostic potential than conventional markers. The gut microbiome may also regulate bone metabolism, with metabolites like trimethylamine N-oxide (TMAO) playing a role. A project aims to promote systematic physical activity to improve BMD and well-being, support societal mobilization, and conduct preventive examinations for osteoporosis risk. Implementing systematic prevention is important not only for health but also for reducing social and financial costs associated with osteoporosis and associated fractures.

Conditions

Osteoporosis; Osteopenia

Keywords

physical activity; bone mineral density

Outcome Measures

Primary Outcomes (1)

• bone mineral density

  BMD using dual-energy X-ray absorptiometry (DXA)

  before and after 12 months of intervention

Secondary Outcomes (2)

• blood markers

  before and after 12 months of intervention

• physical fitness tests

  before and after 12 months of intervention

Study Arms (1)

exercise

EXPERIMENTAL

supervised exercise training; twice a week for 12 months

Other: Exercise

Interventions

Exercise OTHER

supervised exercise training; twice a week for 12 months

exercise

Eligibility Criteria

• Age: 50 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• women

You may not qualify if:

• diagnosed osteoporosis

Sponsors & Collaborators

• Poznan University of Physical Education: lead

Study Sites (1)

Poznan University of Physical Education

Poznan, 61-871, Poland

RECRUITING

MeSH Terms

Conditions

Osteoporosis; Bone Diseases, Metabolic; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Robert A Olek, professor

  Poznan University of Physical Education

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Maja Mackowiak

CONTACT

+48618355270; kosci@awf.poznan.pl

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 18, 2024
• First Posted: September 23, 2024
• Study Start: September 13, 2024
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): June 30, 2027
• Last Updated: October 10, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

PL (1)