The Role of Regular Physical Activity in Enhancing Metabolic Health, Reducing Inflammation, and Improving Gut Function

NCT06606678 | Enrolling By Invitation

• 1 other identifier: 423/24
• Study Type: interventional
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if regular physical activity can improve metabolic health, reduce inflammation, and decrease gut permeability in individuals aged 50 and older. The main questions it aims to answer are: Does regular physical activity, even at low intensity, improve metabolic parameters? Does physical activity reduce inflammation and gut permeability in older adults? Researchers will compare a group participating in low-intensity dance classes to a group participating in higher-intensity calisthenics training to see if the intensity of exercise has different effects on these outcomes. Participants will be asked to: Attend organized training sessions led by instructors twice a week for 12 months. Complete anthropometric measurements (height, weight) and body composition analysis (DXA scan). Provide blood samples for biochemical analysis (glucose, insulin, CRP, etc.). Submit stool samples for gut health markers (calprotectin, zonulin, etc.). Complete surveys on lifestyle and dietary habits before and after the study.

Conditions

Intestinal Inflammation; Metabolic Disease

Keywords

physical activity; metabolic health; inflammation; gut function; older adults

Outcome Measures

Primary Outcomes (1)

• Improvement in insulin sensitivity

  To assess the primary outcome measure of improvement in insulin sensitivity, we will use the HOMA-IR index.

  before and after 12 months of intervention

Secondary Outcomes (1)

• Reduction in gut inflammation

  before and after 12 months of intervention

Study Arms (1)

excercise

EXPERIMENTAL

supervised excercise training; twice a week for 12 months

Other: Exercise

Interventions

Exercise OTHER

supervised exercise training; twice a week for 12 months

excercise

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age over 50 years
• No contraindications for engaging in physical activity

You may not qualify if:

• Presence of diseases that prevent participation in physical activity

Sponsors & Collaborators

• Poznan University of Physical Education: lead

Study Sites (1)

Poznań University of Physical Education

Poznan, 60-213, Poland

Location

MeSH Terms

Conditions

Metabolic Diseases; Motor Activity; Inflammation

Interventions

Exercise

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases; Behavior; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Ewa Bryl, PhD

  Poznan Univeristy of Physical Education

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 18, 2024
• First Posted: September 23, 2024
• Study Start: September 17, 2024
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): June 30, 2027
• Last Updated: September 23, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

PL (1)