Caffeine, Resistance Exercise and EMG

NCT06606652 | Completed

• 1 other identifier: CEIP/2023/4/093_2
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Several studies have evaluated and confirmed the ergogenic effects of acute caffeine intake on sports performance. However, some studies suggest that this effect predominantly occurs in large muscle groups, potentially due to increased skeletal muscle electrical activity. Objectives: This study aims to evaluate the acute effects of caffeine intake on strength, power, muscle endurance, and muscle electrical activity in young adults. It will also analyze the influence of circadian rhythms (morning vs. afternoon) on exercise performance (bench press vs. squat). Methods: Twelve healthy, physically active participants will be recruited for the study. Using a triple-blind, crossover, randomized, and controlled design, participants will ingest either caffeine (3 mg/kg body mass) or a placebo (maltodextrin, 3 mg/kg) 60 minutes before the trial. Muscular strength, power, and endurance performance will then be assessed through 1RM tests, and at 25%, 50%, 75%, and 90% of 1RM, along with muscle endurance tests at 65% of 1RM, for both squat and bench press exercises. EMG will be used to measure skeletal muscle electrical activity during the tests. The experimental sessions will be conducted in the morning (8:00 am to 10:00 am) and the afternoon (4:30 pm to 6:30 pm).

Conditions

Caffeine

Outcome Measures

Primary Outcomes (8)

• Mean velocity at different %1RM

  Measuring bar mean velocity desplacement during bench press and back squat exercises.

  Through study completion, an average of 4 weeks

• Peak velocity at different %1RM

  Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.

  Through study completion, an average of 4 weeks

• Mean power output at different %1RM

  Measuring during bench press and back squat exercises.

  Through study completion, an average of 4 weeks

• Peak power output and time to reach peak power output at different %1RM

  Measuring during bench press and back squat exercises.

  Through study completion, an average of 4 weeks

• Number of repetitions performed in 1 set at 65%1RM until task failure

  Through study completion, an average of 4 weeks

• Bar velocity deplacement performed in 1 set at 65%1RM until task failure

  In bench press and back squat exercises

  Through study completion, an average of 4 weeks

• Power output generated in 1 set at 65%1RM until task failure

  In bench press and back squat exercise

  Through study completion, an average of 4 weeks

• Muscle electrical activity (EMG).

  Root-mean-square (RMS) and maximal voluntary contraction (MVC) from pectoralis major and triceps (bench press) and from rectus femoris and vastus lateralis (Back squat).

  Through study completion, an average of 4 weeks

Secondary Outcomes (2)

• Mood state (tension, depression, anger, vigor, fatigue and confusion)

  Through study completion, an average of 4 weeks

• Adverse effects

  Through study completion, an average of 4 weeks

Study Arms (4)

Caffeine - Morning

EXPERIMENTAL

Dietary Supplement: Caffeine

Caffeine - Evening

EXPERIMENTAL

Dietary Supplement: Caffeine

Placebo - Morning

PLACEBO COMPARATOR

Dietary Supplement: Placebo

Placebo - Evening

PLACEBO COMPARATOR

Dietary Supplement: Placebo

Interventions

Caffeine DIETARY_SUPPLEMENT

Acute caffeine intake (3 mg/kg)

Caffeine - Evening; Caffeine - Morning

Placebo DIETARY_SUPPLEMENT

Acute placebo intake (3 mg/kg of maltodextrin)

Placebo - Evening; Placebo - Morning

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18 and 35 years.
• Body Mass Index (BMI) \< 25 kg/m².
• Resistance-trained individuals (more than 2 years of structured training).
• Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising.
• Participants must be able to perform the tests described in the following section.

You may not qualify if:

• History of neuromuscular diseases, heart disease, or conditions that may affect liver or muscle metabolism.
• Use of drugs, stimulants, or sports supplements that could interfere with the dietary supplement used in the study.
• Sedentary habits (less than 150 minutes/week of moderate exercise).
• Having undergone prolonged periods of physical inactivity in the 6 months prior to the study.
• Engaging in strenuous exercise within 48 hours prior to the tests.
• Failure to replicate the same food intake on both experimental days.
• Consumption of caffeine or any other stimulant after 6 pm on the day before the tests, to avoid headaches, discomfort, or lethargy in regular caffeine consumers.

Sponsors & Collaborators

• University of Alcala: lead

Study Sites (1)

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, 28805, Spain

Location

MeSH Terms

Interventions

Caffeine

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Statistician
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 9, 2024
• First Posted: September 23, 2024
• Study Start: September 1, 2023
• Primary Completion: April 30, 2024
• Study Completion: April 30, 2024
• Last Updated: September 23, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will share

Locations

ES (1)