Caffeine and Training Intensity Quantification

NCT06210984 | Unknown

• 1 other identifier: Stmarys1
• Study Type: interventional
• Target: 36
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial is to learn about the effects of caffeine on exercise physiology and the subsequent quantification of athlete training zones in trained cyclists. The main questions that it aims to answer are:

• What are the effects of low and moderate doses of caffeine on exercise physiology.
• How do the effects of caffeine on exercise physiology affect the calculation of training zones.
• Do the effects of caffeine on exercise physiology differ between men and women. Participants will complete four trials on a cycle ergometer as follows:
• Trial 1: participants will complete two incremental tests to determine the power outputs required to elicit 50-80% of maximal oxygen consumption for trials 2-4.
• Trials 2-4: participants will consume (in a randomized order) either a low (2 mg/kg) dose of caffeine, a moderate (5 mg/kg) dose of caffeine, or a placebo (maltodextrin), 45 minutes prior to to completing an incremental cycling test from 50-80% of maximal oxygen uptake. Measures of heart rate, oxygen uptake, blood lactate, and perceived exertion will be recorded throughout all trials. Researchers will compare the effects of exercise intensity, caffeine dose, and sex to see if they affect exercise physiology and training zone quantification.

Conditions

Caffeine

Outcome Measures

Primary Outcomes (4)

• Blood lactate concentration

  Change from baseline in blood lactate concentration measured at rest and at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

  From baseline to completion, up to 31 days

• Heart rate

  Change from baseline in heart rate measured at rest and at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

  From baseline to completion, up to 31 days

• Oxygen uptake

  Change from baseline in oxygen uptake measured at rest and at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

  From baseline to completion, up to 31 days

• Perceived exertion

  Change from baseline in rating of perceived exertion measured (using the 6-20 Borg scale) at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

  From baseline to completion, up to 31 days

Study Arms (3)

Low caffeine dose

EXPERIMENTAL

2 mg/kg dose of caffeine (in pill form)

Drug: Low caffeine dose

Moderate caffeine dose

EXPERIMENTAL

5 mg/kg dose of caffeine (in pill form)

Drug: Moderate caffeine dose

Placebo

PLACEBO COMPARATOR

5 mg/kg dose of placebo (Maltodextrin in pill form)

Drug: Placebo

Interventions

Low caffeine dose DRUG

2 mg/kg dose of caffeine in pill form

Low caffeine dose

Moderate caffeine dose DRUG

5 mg/kg dose of caffeine in pill form

Moderate caffeine dose

Placebo DRUG

5 mg/kg dose of maltodextrin in pill form

Placebo

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

Sponsors & Collaborators

• St. Mary's University, Twickenham: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 8, 2024
• First Posted: January 18, 2024
• Study Start: January 31, 2024
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: January 18, 2024

Record last verified: 2024-01