Reproducibility of Acute Caffeine Effect

NCT06606639 | Completed

• 1 other identifier: CEID/2024/2/039
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Various studies have evaluated and verified the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, all experimental investigations designed so far have been based on the comparison of the \"caffeine\" and \"placebo\" conditions in a single trial, not considering the reproducibility and variability of caffeine in multiple trials. Objectives: The present study aims to evaluate the reproducibility and replicability of the acute effect of caffeine intake on energy metabolism and the muscular production of force, power and endurance, according to sex (men vs women) and type of exercise ( bench press vs squat).

Conditions

Caffeine and Resistance Exercise

Outcome Measures

Primary Outcomes (9)

• Mean velocity at different %1RM

  Measuring bar mean velocity desplacement during bench press and back squat exercises.

  Through study completion, an average of 4 weeks

• Peak velocity at different %1RM

  Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.

  Through study completion, an average of 4 weeks

• Mean power output at different %1RM

  Measuring during bench press and back squat exercises.

  Through study completion, an average of 4 weeks

• Peak power output and time to reach peak power output at different %1RM

  Measuring during bench press and back squat exercises.

  Through study completion, an average of 4 weeks

• Number of repetitions performed in 1 set at 65%1RM until task failure

  In bench press and back squat exercises

  Through study completion, an average of 4 weeks

• Bar velocity deplacement performed in 1 set at 65%1RM until task failure

  In bench press and back squat exercises

  Through study completion, an average of 4 weeks

• Power output generated in 1 set at 65%1RM until task failure

  In bench press and back squat exercise

  Through study completion, an average of 4 weeks

• Resting Metabolic Rate (RMR)

  Kcal at rest measuring (RMR) using a metabolic chart.

  Through study completion, an average of 4 weeks

• Maximal Fat Oxidation Rate (MFO)

  g/min (MFO) using a metabolic chart.

  Through study completion, an average of 4 weeks

Secondary Outcomes (6)

• Physical activity (METs-min/wk)

  Through study completion, an average of 4 weeks

• Dietary (g/kg of macronutrients)

  Through study completion, an average of 4 weeks

• Mood state

  Through study completion, an average of 4 weeks

• Adverse effects

  Through study completion, an average of 4 weeks

• Fat mass

  Through study completion, an average of 4 weeks

Study Arms (5)

Caffeine - Trial 1

EXPERIMENTAL

Dietary Supplement: Caffeine

Caffeine - Trial 2

EXPERIMENTAL

Dietary Supplement: Caffeine

Caffeine - Trial 3

EXPERIMENTAL

Dietary Supplement: Caffeine

Placebo - Trial 1

PLACEBO COMPARATOR

Dietary Supplement: Placebo

Placebo - Trial 2

PLACEBO COMPARATOR

Dietary Supplement: Placebo

Interventions

Caffeine DIETARY_SUPPLEMENT

acute caffeine intake (3 mg/kg)

Caffeine - Trial 1; Caffeine - Trial 2; Caffeine - Trial 3

Placebo DIETARY_SUPPLEMENT

Acute placebo intake (3 mg/kg of maltodextrin)

Placebo - Trial 1; Placebo - Trial 2

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between ≥ 18 and ≤ 35 years.
• Body Mass Index (BMI) \< 25 kg/m².
• Resistance-trained individuals (\> 2 years of structured trained).
• Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising.
• Participants must be able to perform the tests described in the following section.

You may not qualify if:

• History of neuromuscular diseases, heart diseases, or diseases that may affect liver or muscle metabolism.
• Use of drugs, other stimulants or sport supplements that interfere with the the study dietary supplement.
• Sedentary habits (\<150 min/week of moderate exercise).
• Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
• Performing strenuous exercise during the 48 hours prior to the tests.
• Failure to replicate the same food intake on the two days of the experiments.
• Consuming caffeine or any other stimulant after 6 pm the day before the training or tests, to avoid headaches, discomfort, or lethargy among regular caffeine consumers.

Sponsors & Collaborators

• University of Alcala: lead

Study Sites (1)

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, 28805, Spain

Location

MeSH Terms

Interventions

Caffeine

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Statistician
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 9, 2024
• First Posted: September 23, 2024
• Study Start: January 8, 2024
• Primary Completion: May 22, 2024
• Study Completion: May 22, 2024
• Last Updated: May 25, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share

Locations

ES (1)