Caffeine, Resistance Exercise and Muscle/Cerebral Oxygenation

NCT07001176 | Completed

• 1 other identifier: CEID/2023/3/070
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Several studies have evaluated and confirmed the ergogenic effects of acute caffeine intake on sports performance. However, the mechanism responsible for this ergogenic effect remains to be elucidated. Objectives: This study aims to evaluate the acute effects of caffeine intake on muscle and cerebral oxygen during muscular strength, power, muscle endurance performance. and muscle electrical activity in young adults.

Conditions

Caffeine and Resistance Exercise

Outcome Measures

Primary Outcomes (5)

• Muscle Oxygenation

  Measuring oxygen in the muscle before and after exercise.

  Through study completion, an average of 2 weeks

• Cerebral oxygenation

  Measuring cerebral oxygenation before and after exercise.

  Through study completion, an average of 2 weeks

• Number of repetitions performed in 1 set at 65%1RM until task failure

  Through study completion, an average of 2 weeks

• Bar velocity deplacement performed in 1 set at 65%1RM until task failure

  In bench press and back squat exercises

  Through study completion, an average of 2 weeks

• Power output generated in 1 set at 65%1RM until task failure

  In bench press and back squat exercise

  Through study completion, an average of 2 weeks

Study Arms (2)

Caffeine

EXPERIMENTAL

Acute caffeine intake (3 mg/kg)

Dietary Supplement: Caffeine

Placebo

PLACEBO COMPARATOR

Acute placebo intake

Dietary Supplement: Placebo

Interventions

Caffeine DIETARY_SUPPLEMENT

Acute caffeine intake (3 mg/kg)

Caffeine

Placebo DIETARY_SUPPLEMENT

Acute placebo intake (3 mg/kg)

Placebo

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18 and 35 years.
• Body Mass Index (BMI) \< 25 kg/m².
• Resistance-trained individuals (more than 2 years of structured training).
• Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising.
• Participants must be able to perform the tests described in the following section.

You may not qualify if:

• History of neuromuscular diseases, heart disease, or conditions that may affect liver or muscle metabolism.
• Use of drugs, stimulants, or sports supplements that could interfere with the dietary supplement used in the study.
• Sedentary habits (less than 150 minutes/week of moderate exercise).
• Having undergone prolonged periods of physical inactivity in the 6 months prior to the study.
• Engaging in strenuous exercise within 48 hours prior to the tests.
• Failure to replicate the same food intake on both experimental days.
• Consumption of caffeine or any other stimulant after 6 pm on the day before the tests, to avoid headaches, discomfort, or lethargy in regular caffeine consumers.

Sponsors & Collaborators

• University of Alcala: lead

Study Sites (1)

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, Spain

Location

MeSH Terms

Interventions

Caffeine

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Statistician
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 23, 2025
• First Posted: June 3, 2025
• Study Start: January 1, 2024
• Primary Completion: December 23, 2024
• Study Completion: December 23, 2024
• Last Updated: June 3, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share

Locations

ES (1)