Effects Of Caffeine On Cognitive Performance

NCT05995314 | Completed DMC

• 1 other identifier: CAF_MR_2023
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Caffeine is a potent central nervous system stimulant that increases the activity in the prefrontal cortex and can improve cognitive skills. An improvement in these cognitive skills can lead to further benefits in athletic performance. Therefore, it is necessary to clarify the dose-response of caffeine on cognitive performance.The aim of this research will be to determine the effects of different doses of caffeine on sport-related cognitive aspects.

Conditions

Caffeine

Keywords

ergogenic aid; sport performance; reaction time; anticipation; attention; memory

Outcome Measures

Primary Outcomes (4)

• Reaction Time

  Reaction time (in seconds) shall be assessed with the Dynavision™ D2 Visomotor Device using the "Reaction Time Test". In this test the fastest visual, motor and physical reaction time will be measured.

  10 minutes

• Anticipation

  Visual acuity related to hand-eye coordination and anticipation will be assessed using the Bassin Anticipation Timer instrument. The best anticipation time (in seconds) of each condition (5, 10 and 15 mph) will be taken.

  5 minutes

• Sustained attention

  The ability of maintaining the attention and inhibiting an appropriate response will be measured by "Go/No-Go Test" \[fastest, slowest, and average response time (in seconds), and successful attempts (percentage; %)\] and "Eriksen Flanker Test" \[congruent and incongruent reaction time (in seconds)\].

  10 minutes

• Memory

  To study the modulation of memory storage processes, three 20-item word lists were created. Each word in the list will be presented for 5 s. This will be followed by a 100 s memory consolidation interval, after which there will be a 120 s period in which as many words as the participants can remember will be written down (First time). After 15 min, participants will perform a recall task (Second time) in which they will have to rewrite all the words they remember at that time.

  20 minutes

Study Arms (3)

PLACEBO

PLACEBO COMPARATOR

placebo (0 mg/kg of body mass of caffeine). The capsule will be filled with 3 mg/kg of body mass of cellulose.

Dietary Supplement: PLACEBO

3mg/kg

EXPERIMENTAL

3 mg/kg of body mass of caffeine (99% caffeine, Bulkpowders, United Kingdom).

Dietary Supplement: 3 mg/kg of caffeine

6mg/kg

EXPERIMENTAL

6 mg/kg of body mass of caffeine (99% caffeine, Bulkpowders, United Kingdom).

Dietary Supplement: 6 mg/kg of caffeine

Interventions

PLACEBO DIETARY_SUPPLEMENT

3 mg/kg of cellulose (0 mg/kg of caffeine)

PLACEBO

3 mg/kg of caffeine DIETARY_SUPPLEMENT

Ingestion of 3 mg/kg of body mass of caffeine

3mg/kg

6 mg/kg of caffeine DIETARY_SUPPLEMENT

Ingestion of 6 mg/kg of body mass of caffeine

6mg/kg

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Physically active individuals ( \>150 min/week moderate physical activity or \>75 min/week vigorous physical activity)
• Individuals without serious and undiagnosed health problems.

You may not qualify if:

• Individuals with color blindness.
• Regular caffeine consumers (\>3 cups of coffee/day).

Sponsors & Collaborators

• University of Castilla-La Mancha: lead

Study Sites (1)

Performance and Sport Rehabilitation Laboratory

Toledo, 45071, Spain

Location

Related Publications (1)

• Ramirez-delaCruz M, Esteban-Garcia P, Abian P, Bravo-Sanchez A, Pinas-Bonilla I, Abian-Vicen J. Effects of different doses of caffeine on cognitive performance in healthy physically active individuals. Eur J Nutr. 2024 Dec;63(8):3025-3035. doi: 10.1007/s00394-024-03486-9. Epub 2024 Sep 4.

  PMID: 39231871 DERIVED

MeSH Terms

Interventions

Caffeine

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Officials

• Javier Abián-Vicén, PhD

  University of Castilla-La Mancha

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: To achieve the blinded placebo situation, a researcher not associated with the study will be performed the blinding and prepared identical capsules containing placebo or the corresponding dose of caffeine. This researcher will be assigned an alphanumeric code to each trial to blind participants and investigators
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 8, 2023
• First Posted: August 16, 2023
• Study Start: August 7, 2023
• Primary Completion: September 4, 2023
• Study Completion: September 4, 2023
• Last Updated: September 6, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)