Brain Activity, Cognitive Function, and Walking Ability in Parkinson's Disease

NCT06588920 | Recruiting

• 1 other identifier: NYCU113006AF1
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 2

Brief Summary

The dual-task automated walking performance in people with Parkinson\'s disease (PD) is affected by their gait disturbances and impaired executive functions. Currently, the relationship between brain activity related to inhibitory control, executive functions, and dual-task walking performance in people with PD is not well understood. Therefore, this study aims to investigate the significance of different executive function domains on gait stability in healthy older adults and people with PD; whether brain activation related to inhibitory control is associated with gait stability in healthy older adults and people with PD.

Conditions

Healthy Older Adults; Parkinson Disease

Keywords

Executive function; Gait; Electroencephalography

Outcome Measures

Primary Outcomes (13)

• Gait variability

  Using GAITRite system to measure the coefficient of variation (CV). The mean and standard deviation will be used to calculate the coefficient of variation (CV). CV = standard deviation / mean \* 100%

  1 day

• Gait speed

  Using GAITRite system to measure gait speed.

  1 day

• Step length

  Using GAITRite system to measure step length

  1 day

• Step width

  Using GAITRite system to measure step width.

  1 day

• Single support time

  Using GAITRite system to measure single support time

  1 day

• Double support time

  Using GAITRite system to measure double support time

  1 day

• Frontal Assessment Battery

  The score ranged from 0 to 18. Higher scores show better executive function.

  1 day

• Trail making test

  Trail making test contain part A and part B. Faster completing the test indicates better executive function.

  1 day

• Stroop color and word test

  Record numbers of corrected color words which the subject responds within 45 sec.

  1 day

• Digit span test

  Digit span test contain forward and backward part. Scores of forward digit span ranges from 0 to 16. Score of backward digit span ranges from 0 to 14. Higher scores indicate better executive function.

  1 day

• Event-related potential - N2

  Measure event-related potential through electroencephalography under single-task and dual-task paradigm.

  1 day

• Event-related potential - P300

  Measure event-related potential through electroencephalography under single-task and dual-task paradigm.

  1 day

• Go/Nogo test

  Behavioral test during measuring electroencephalography.

  1 day

Study Arms (2)

Parkinson disease

People with Parkinson disease

Behavioral: Cognitive function, gait, and electroencephalogram

Healthy older adults

Healthy older adults

Behavioral: Cognitive function, gait, and electroencephalogram

Interventions

Cognitive function, gait, and electroencephalogram BEHAVIORAL

Measurement of cognitive function, gait performance, and electroencephalogram

Healthy older adults; Parkinson disease

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hospital and community

You may qualify if:

• Diagnoses of idiopathic Parkinson disease
• Stable dopaminergic medicine ≥ 2 weeks
• Able to walk 10 meters without aid
• Mini-Mental Status Examination ≥ 24 points
• No uncorrected visual or auditory disorders
• Education at least junior high school
• No other disease may affect balance

You may not qualify if:

• Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders
• History of brain surgery (e.g. deep brain stimulation)

Sponsors & Collaborators

• National Yang Ming Chiao Tung University: lead

Study Sites (2)

National Yang Ming Chiao Tung University

Taipei, Taiwan

RECRUITING

National Yang Ming Chiao Tung University

Taipei, Taiwan

RECRUITING

MeSH Terms

Conditions

Parkinson Disease

Interventions

Gait

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Walking; Locomotion; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Yea-Ru Yang, PhD

CONTACT

+886228267279; yryang@nycu.edu.tw

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 5, 2024
• First Posted: September 19, 2024
• Study Start: October 9, 2024
• Primary Completion (Estimated): August 31, 2027
• Study Completion (Estimated): August 31, 2027
• Last Updated: March 24, 2026

Record last verified: 2026-03

Locations

TW (2)