Balance Performance and Corticomotor Inhibition in PD

NCT05066659 | Unknown DMC

• 1 other identifier: YM110122F
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Postural instability is one of the motor features of Parkinson's disease (PD). Most patients will develop balance dysfunction, and they may get worse with disease progression. According to previous studies, people with PD had abnormal changes in corticomotor excitability, especially disinhibition in the primary motor cortex (M1). Some evidence had shown that the cortical function in the M1 is crucial for the pathophysiology of the underlying motor symptoms in PD. Furthermore, neurostimulation over the M1 could modulate the corticomotor excitability in individuals with PD, and then improve their motor and also balance performance. However, whether the impaired corticomotor inhibition relates to balance dysfunction in people with PD is still unknown. In this study, the purpose is to investigate the possible relationship between corticomotor inhibition and balance performance in individuals with PD. However, the postural position during TMS measurement may affect the corticomotor excitability. To further establish the above-mentioned relationship, the secondary purpose is to explore and confirm whether the postural position will influence the correlation.

Conditions

Parkinson Disease

Keywords

Parkinson's disease; Transcranial magnetic stimulation; Motor cortex; Corticomotor inhibition; Balance performance

Outcome Measures

Primary Outcomes (5)

• Intracortical inhibition

  Short-interval intracortical inhibition assessed by transcranial magnetic stimulation

  20 minutes

• Corticospinal inhibition

  Cortical silent period assessed by transcranial magnetic stimulation

  20 minutes

• Static balance

  Sharpened Romberg test

  3 minutes

• Dynamic balance

  Functional reach test

  5 minutes

• Functional balance

  Mini-Balance Evaluation Systems Test

  15 minutes

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

people with Parkinson's disease

You may qualify if:

• the Hoehn and Yahr stage between 1 and 3
• age 40 to 80 years
• a stable treatment of anti-PD medications

You may not qualify if:

• any contraindications of TMS
• any injury histories or disorders affecting balance
• any neurosurgery experience
• neurologic conditions other than PD
• the Mini-mental State Examination (MMSE) score \< 24

Sponsors & Collaborators

• National Yang Ming Chiao Tung University: lead

Study Sites (1)

Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University

Taipei, 112, Taiwan

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Central Study Contacts

Yea-Ru Yang, PhD

CONTACT

886228267279; yryang@nycu.edu.tw

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 23, 2021
• First Posted: October 4, 2021
• Study Start: October 8, 2021
• Primary Completion: September 8, 2022
• Study Completion: September 8, 2022
• Last Updated: October 4, 2021

Record last verified: 2021-09

Locations

TW (1)