Short Term Outcome Following Post Operative Enhanced Recovery Implementation in Patients With Perforated Peptic Ulcer

NCT06570018 | Completed

• 1 other identifier: Enhanced recovery
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to evaluate the effect of implementing post operative enhanced recovery on perforated peptic ulcer surgery outcome. The current study anticipated better outcomes in the form of early functional recovery, reduced length of hospital stays, less thirty days post operative morbidity, and better gastrointestinal quality of life after implementing post operative enhanced recovery in patients with perforated peptic ulcer.

Conditions

Emergent Surgery; Perforated Peptic Ulcer

Outcome Measures

Primary Outcomes (5)

• Gastrointestinal functional recovery (first bowel movement)

  Tool; Patient assessment sheet * It was developed by researchers based on literatures review to assess postoperative clinical data (part 2) as gastrointestinal functional recovery (first bowel movement) through physical examination. * The mean score of time for two groups was compared

  Within the first 24 hours postoperative or more

• Gastrointestinal functional recovery(first flatus passage)

  Tool; Patient assessment sheet * It was developed by researchers based on literatures review to assess postoperative clinical data (part 2) as gastrointestinal functional recovery (first flatus passage) through physical examination. the mean score of time for two groups was compared

  Within the first 24 hours postoperative or more

• Gastrointestinal functional recovery(first stool passage)

  Tool; Patient assessment sheet \- It was developed by researchers based on literatures review to assess postoperative clinical data (part 2) as gastrointestinal functional recovery (first stool passage) postoperative.through health history. The mean score of time for two groups was compared

  First stool passage within three days postoperative or more

• postoperative complications

  post operative complications included complications that occured within 30- days post operative. Every patient had been assessed for developing pneumonia, admission to critical care, abdominal collection, intra-abdominal abscess, suture leakage, omental patch leakage, septic shock, prolonged ileus, surgical site infection, urinary tract infection, deep venous thrombosis (DVT), and reoperation

  Immediately post operative up to thirty days postoperative

• Legnth of hospital stay

  Hospitalization duration from admission up to discharge Mean score of days for two groups will be compared.

  seven days up to two weeks

Secondary Outcomes (1)

• gastrointestinal quality of life

  Before hospital dicharge and after thirty days postoperative

Study Arms (2)

Enhanced recovery group

EXPERIMENTAL

who received postoperative enhanced recovery after open surgical repair for perforated peptic ulcer

Procedure: Post operative enhanced recovery elements

Control group

NO INTERVENTION

who exposed to standard care

Interventions

Post operative enhanced recovery elements PROCEDURE

According to the study group the researchers collaborated with surgeons, nurses, and anesthesiologists to implement post operative enhanced recovery protocol that defined clearly in the following elements Early nutrition, Early mobilization, Non-opioid analgesia. Early removal of abdominal drains and tubes throughout the patients' hospital stay up to their discharge.

Enhanced recovery group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ranged from 18 to 65 years,
• Diagnosed with perforated peptic ulcer,
• Ulcer size less than 10 mm.
• Underwent emergent surgical intervention

You may not qualify if:

• Malignant ulcer.
• Other GIT diseases (corn's disease \& ulcerative colitis)
• Pregnant women
• Psychiatric or neurological illness.
• Who refused to participate in the study

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Faculty of Nursing

Asyut, 71111, Egypt

Location

Related Publications (1)

• Desoky AA, Ayoub MT, Mostafa NM, Hashem EM, Mohammed MA. Short-term outcome following postoperative enhanced recovery implementation in patients with perforated peptic ulcer. Eur J Med Res. 2025 Apr 4;30(1):234. doi: 10.1186/s40001-025-02432-7.

  PMID: 40186297 DERIVED

MeSH Terms

Conditions

Peptic Ulcer Perforation

Condition Hierarchy (Ancestors)

Peptic Ulcer; Duodenal Diseases; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Stomach Diseases

Study Officials

• Mahmoud Ayoub, Ass. prof.

  Assiut University -Assiut city

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assisstant professor of Medical Surgical Nursing

Study Record Dates

• First Submitted: August 20, 2024
• First Posted: August 26, 2024
• Study Start: October 1, 2023
• Primary Completion: July 15, 2024
• Study Completion: August 15, 2024
• Last Updated: January 29, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)