Timing and Resistance Exercise: Impact on Eating and Metabolism

NCT06549322 | Not Yet Recruiting

• 1 other identifier: 202401HM008
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

Exercise timing (morning or evening) for optimal weight control is a research topic urgently addressed by scholars in the relevant field. Due to the better control of energy metabolism and physical activity levels in the morning, existing research on resistance exercise and eating behavior primarily focuses on experiments conducted in the morning, with only one study in the afternoon. No research has yet compared the potential differences between morning and evening resistance exercise. A one-year study aims to investigate the impact of morning and evening resistance exercise on physiological metabolism and eating behavior. Eighteen healthy male participants will be randomly assigned to a crossover design study, including AM exercise, PM exercise, and control (rest condition) trials. Variables including subjective appetite, appetite hormones (ghrelin, peptide YY), food preferences, ad libitum eating, dietary records, energy expenditure, and PBMCs circadian rhythm genes will be measured. This preliminary study through a multidimensional observation, the results will contribute to understanding the potential differences and mechanisms of morning and evening resistance exercise on physiological metabolism and eating behavior. In practical applications, conducting resistance exercise in the evening or at night aligns better with current lifestyles. The findings of this study can support the optimization of exercise benefits by validating the choice of exercise timing.

Conditions

Circadian Rhythm; Energy Balance; Appetitive Behavior; Food Reward

Keywords

resistance exercise; energy expenditure

Outcome Measures

Primary Outcomes (8)

• Subjective appetite Subjective appetite Subjective appetite Subjective appetite Subjective appetite Subjective appetite

  The appetite perceptions are obtained through a 0-100 mm visual analog scale. The variables assessed include perceptions of hunger (i.e., "How hungry do you feel?"), satisfaction (i.e., "How satisfied do you feel?"), fullness (i.e., "How full do you feel?"), prospective food consumption (i.e., "How much do you think you can eat?"), and nausea (i.e., "How nauseous do you feel?"), with 0 indicating "not at all" and 100 signifying "extremely.".

  3 hours during each study intervention

• Change in acyl-Ghrelin

  acyl-Ghrelin in pg/mL

  3 hours during each study intervention

• Change in PYY

  PYY in pg/mL

  3 hours during each study intervention

• Change in Leptin

  Leptin in pg/mL

  3 hours during each study intervention

• Change in lactate

  lactate in mmol/L

  3 hours during each study intervention

• Change in PBMCs circadian rhythm genes

  Circadian rhythm genes in PBMC will be measured, such as Bmal1, Clock, Per1, Per2, Per3, Cry1, Cry2, Cry3, and Tbp in arbitrary units.

  3 hours during each study intervention

• Energy intake

  Participants will be required to record their diet for the day before, the current day, and the day following the experiment. The energy intake include absolute energy intake and relative energy intake .

  The Before day, the durning day, and the day following the experiment.

• Energy expenditure

  Participants will record energy expenditure during resistance exercise, with non-exercise energy expenditure measured using an accelerometer.

  The Before day, the durning day, and the day following the experiment.

Secondary Outcomes (9)

• Explicit liking

  3 hours during each study intervention

• Explicit wanting

  3 hours during each study intervention

• Implicit wanting

  3 hours during each study intervention

• Relative preference

  3 hours during each study intervention

• Taste appeal bias

  3 hours during each study intervention

Study Arms (3)

The exercise in morning

EXPERIMENTAL

Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 60 sec of rest between sets.

Other: The exercise in morning

The exercise in evening

EXPERIMENTAL

Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 60 sec of rest between sets.

Other: The exercise in evening

The control in all day

NO INTERVENTION

Sit and rest in the morning and evening during the day.

Interventions

The exercise in morning OTHER

Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 60 sec of rest between sets. Exercise timing: AM 11:00-11:30

The exercise in morning

The exercise in evening OTHER

Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 60 sec of rest between sets. Exercise timing: PM 05:00-05:30

The exercise in evening

Eligibility Criteria

• Age: 20 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age: 20-30
• weight stable for at least 6 months

You may not qualify if:

• Obesity (BMI \> 30 kg/m² or body fat percentage \> 25%)
• Hypertension (blood pressure over 140/90 mmHg)
• Heart disease
• Cancer
• Liver or kidney diseases
• Any other conditions that could potentially influence the study's outcomes

Sponsors & Collaborators

• National Taiwan Normal University: lead

Study Sites (1)

National Taiwan Normal University

Taipei, 106, Taiwan

Location

MeSH Terms

Conditions

Appetitive Behavior

Condition Hierarchy (Ancestors)

Behavior, Animal; Behavior

Study Officials

• Hung-wen Liu, Ph.D.

  National Taiwan Normal University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hung-wen Liu, Ph.D.

CONTACT

+886 0277496863; hwliu@ntnu.edu.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 8, 2024
• First Posted: August 12, 2024
• Study Start: September 1, 2024
• Primary Completion: December 30, 2025
• Study Completion: December 30, 2025
• Last Updated: August 12, 2024

Record last verified: 2024-08

Locations

TW (1)