NCT06223282

Brief Summary

Healthy young males will complete five trials in a randomized crossover counter-balanced order, including three different inter-set rest of resistance exercise in equal training volume, one repeated until failure and sedentary control. During each trial, blood samples will be collected. The investigators hypothesized that different inter-set rest and training volume would affect subjective appetite and energy intake.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
18

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Oct 2022

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 28, 2022

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2023

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

January 4, 2024

Completed
21 days until next milestone

First Posted

Study publicly available on registry

January 25, 2024

Completed
Last Updated

January 25, 2024

Status Verified

January 1, 2024

Enrollment Period

5 months

First QC Date

January 4, 2024

Last Update Submit

January 15, 2024

Conditions

Eating BehaviorFood Reward

Outcome Measures

Primary Outcomes (7)

  • Subjective appetite

    The appetite perceptions were obtained through a 0-100 mm visual analog scale. The variables assessed included perceptions of hunger (i.e., "How hungry do you feel?"), satisfaction (i.e., "How satisfied do you feel?"), fullness (i.e., "How full do you feel?"), prospective food consumption (i.e., "How much do you think you can eat?"), and nausea (i.e., "How nauseous do you feel?"), with 0 indicating "not at all" and 100 signifying "extremely.".

    4-hour during each study intervention

  • Change in acyl-Ghrelin

    acyl-Ghrelin in pg/mL

    4-hour during each study intervention

  • Change in total-Ghrelin

    total-Ghrelin in pg/mL

    4-hour during each study intervention

  • Change in PYY

    PYY in pg/mL

    4-hour during each study intervention

  • Change in active-GLP-1

    active-GLP-1 in pg/mL

    4-hour during each study intervention

  • Change in total-GLP-1

    total-GLP-1 in pg/mL

    4-hour during each study intervention

  • Change in lactate

    insulin in mmol/L

    4-hour during each study intervention

Secondary Outcomes (10)

  • Explicit liking

    4 hours during each study intervention

  • Explicit wanting

    4 hours during each study intervention

  • Implicit wanting

    4 hours during each study intervention

  • Relative preference

    4 hours during each study intervention

  • Fat appeal bias

    4 hours during each study intervention

  • +5 more secondary outcomes

Study Arms (5)

short inter-set rest

EXPERIMENTAL

3 multi-joints resistance exercise with short (60s) inter-set rest

Other: short inter-set rest resistance exercise

medium inter-set rest

EXPERIMENTAL

3 multi-joints resistance exercise with medium(120s) inter-set rest

Other: medium inter-set rest

long inter-set rest

EXPERIMENTAL

3 multi-joints resistance exercise with long (180s) inter-set rest

Other: long inter-set rest

medium inter-set rest with failure

EXPERIMENTAL

3 multi-joints resistance exercise with medium (120s) inter-set rest repeated to failure each set

Other: medium inter-set rest with failure

control

NO INTERVENTION

stayed sedentary during the period.

Interventions

short inter-set rest resistance exerciseOTHER

Subjects in short inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 60 sec of rest between sets.

short inter-set rest
medium inter-set restOTHER

Subjects in medium inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 120 sec of rest between sets.

medium inter-set rest
long inter-set restOTHER

Subjects in long inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 180 sec of rest between sets.

long inter-set rest
medium inter-set rest with failureOTHER

Subjects in long inter-set rest trial performed 3 sets per exercise, repeated to failure with load of 70%-1RM with 120 sec of rest between sets.

medium inter-set rest with failure

Eligibility Criteria

Age20 Years - 30 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Age: 20-30
  • Healthy male

You may not qualify if:

  • No acute or chronic musculoskeletal symptoms
  • Smoking
  • Alcohol or drug abuse
  • Failure to conduct resistance exercise

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan Normal University

Taipei, 106, Taiwan

Location

MeSH Terms

Conditions

Feeding Behavior

Condition Hierarchy (Ancestors)

Behavior, AnimalBehavior

Study Officials

  • Hung-Wen Liu, Ph.D.

    National Taiwan Normal University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 4, 2024

First Posted

January 25, 2024

Study Start

October 28, 2022

Primary Completion

March 31, 2023

Study Completion

March 31, 2023

Last Updated

January 25, 2024

Record last verified: 2024-01

Locations

TW(1)