Breaking Sitting and Metabolic Health in Sedentary Overweight and Obese Adults

NCT05306678 | Completed

• 1 other identifier: 201912HM107-
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary overweight and obese adults.

Conditions

Metabolic Health; Gut Hormones; Energy Balance

Keywords

GLP-1; PYY; Breaking sitting; Energy balance; Postprandial glycaemia

Outcome Measures

Primary Outcomes (1)

• Gut hormones responses

  Changes in blood gut hormones responses (e.g., GLP-1, PYY and GIP concentrations measured in pmol/L) between trials

  320 minutes

Secondary Outcomes (7)

• Visual analogue scale (VAS)

  320 minutes

• Energy intake

  600 minutes after leaving the labalotory

• Physical activity level

  600 minutes after leaving the labalotory

• Lipid profile

  320 minutes

• Blood pressure

  320 minutes

Study Arms (2)

Prolonged sitting

EXPERIMENTAL

Prolonged sitting

Behavioral: Prolonged sitting

Breaking sitting

EXPERIMENTAL

Breaking prolonged sitting

Behavioral: Breaking sitting

Interventions

Prolonged sitting BEHAVIORAL

After consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min.

Prolonged sitting

Breaking sitting BEHAVIORAL

After consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min.

Breaking sitting

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Physical inactive males and females
• Aged between 20 and 45 years
• Overweight and obese healthy adults (waist circumference greater than 90 cm for males and 80 cm for females)
• Weight stable for more than 3 months (no change in weight +/- 3%)
• Non-smoker
• Able to walk comfortably on a treadmill

You may not qualify if:

• Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
• Waist circumference \< 90 cm for male and \< 80 cm for female
• Taking medications that may influence lipid or carbohydrate metabolism or immune system function
• Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)

Sponsors & Collaborators

• National Taiwan Normal University: lead

Study Sites (1)

National Taiwan Normal University

Taipei, Taiwan

Location

Study Officials

• Chen, PhD

  National Taiwan Normal University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 15, 2022
• First Posted: April 1, 2022
• Study Start: December 29, 2020
• Primary Completion: March 1, 2023
• Study Completion: March 1, 2023
• Last Updated: May 1, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)