NCT06483542

Unknown

Bionenergetic Balance During CVVH

Universitair Ziekenhuis Brussel Source

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Other study identifiers

Sponsor study identifier

BUN 1432022000231

Study Type

observational

Actual enrollment (reported)

50

Locations

1 country

Sites

1

Timeline

Study Start

February 1, 2023

Actual (reported)

Primary Completion

April 30, 2023

Actual (reported)

Study Completion

September 30, 2024

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Brief Summary

The bioenergetic balance is the sum of energy exchanged during CRRT and is mostly defined by citrate glucose and lactate. When CRRT was performed with the older dialysis fluids, glucose and lactate could be an important source of energy next to citrate when used as predilution (6, 7). During continuous venovenous hemofiltration (CVVH), a subgroup of CRRT which is performed with the newer dialysis fluids without lactate or glucose as advocated by the KDIGOguidelines, glucose and in a minor way lactate mostly induce a loss of energy. The first aim is to determine how this bioenergetic balance impacts energy need compared to the measured energy with indirect calorimetry and how nutrition therapy needs to be adapted. Also, disease specific predicting equation have been created for patients suffering from acute kidney injury treated with renal replacement therapy. How this predicting equation and other existing predicting equations agree with the measured REE has not been validated yet. The second aim is to determine how predictive equations correlate with measured REE in patients treated with CVVH.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: unknown
Actual enrollment (reported): 50 participants
Study completion date: September 30, 2024
Estimated (date passed)
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
January 24, 2023
Actual (reported)
Study Start
February 1, 2023
Actual (reported)
Primary Completion
April 30, 2023
Actual (reported)
First Posted
July 3, 2024
Actual (reported)
Study Completion
September 30, 2024
Estimated (date passed)
This estimate has passed. The registry has not confirmed an actual date for this milestone.

Last Updated: July 3, 2024
Status Verified: June 2024
Last Update Submitted: July 1, 2024

Conditions

Acute Kidney Injury Continuous Venovenous Hemofiltration Energy Metabolism Nutrition Therapy Resting Energy Expenditure

Outcome Measures

Primary Outcomes (1)

Energy
expressed in Kcal
during study completion, on average 4weeks

Secondary Outcomes (2)

resting energy expenditure
during study completion, on average 4weeks
protein to energy ratio
during study completion, on average 4weeks

Study Arms (1)

Group 1

all patients

Other: bioenergetic balance

Interventions

bioenergetic balanceOther

Bioenergetic balance is calculated for all patients who had a resting energy expenditure measurement with indirect calorimetry.

Group 1

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 130 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Adult critically ill patients with acute kidney injury who require CVVH

You may qualify if:

Patients admitted to the adult ICU (01/01/2021-30/09/2022)

Sponsors & Collaborators

Universitair Ziekenhuis Brussel
Otherlead

Study Sites (1)

Universitair ziekenhuis Brussel

Jette, Vlaams Brabant, 1090, Belgium

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Officials

Joop Jonckheer, PhD
Universitair Ziekenhuis Brussel
PRINCIPAL INVESTIGATOR

Enrollment

50 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: RETROSPECTIVE
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

January 24, 2023

First Posted

July 3, 2024

Study Start

February 1, 2023

Actual (reported)

Not Applicable

Recruiting

NCT06229990

Effect of a Furosemide Stress Test-Guided Strategy on Liberation From Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury

Phase 4Recruiting

NCT06730854

Association Between Liver Function Tests and Acute Kidney Injury in Cardiac Surgery Patients

Completed

NCT06032884

IHD Versus CRRT for Severe Acute Kidney Injury in Critically Ill Patients

Not ApplicableTerminated

NCT05703100

Lactate Profile and Fat Oxidation During Exercise

Not ApplicableCompleted

NCT05796661

Patients Undergoing Continuous Venovenous Hemodiafiltration: Effects of Increased Blood Flow

Not ApplicableUnknown

NCT07207031

Acute Kidney Injury - Epidemiology in Intensive Care Unit Patients 2: an International Multicenter Cohort Study

Enrolling By Invitation

At least one indirect calorimetry measurement (ventilator) or calculation based on harris benedict OR 25Kcal/kg/day

Combined with bio energetic balance measurement

Receiving CVVH during intensive care stay

You may not qualify if:

The absence of an indirect calorimetry measurement (ventilator) or calculation - based on the Harris Benedict OR 25Kcal/kg/day formula OR The absence of a bio energetic balance measurement
The absence of CVVH during intensive care stay
Pediatric (intensive care unit) patients

Contact the study team to confirm eligibility.

Primary Completion

April 30, 2023

Actual (reported)

Study Completion

September 30, 2024

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Last Updated

July 3, 2024

Record last verified: 2024-06

Data Sharing

IPD Sharing: Will share
Shared Documents: STUDY PROTOCOL, CSR
Time Frame: From March 2023 until March 2053

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT06483542
Data provider: ClinicalTrials.gov
Source updated: 2024-07-03
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:37:13 UTC

Locations

BE(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

Study Start

Primary Completion

First Posted

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (1)

Group 1

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations