Association Between Liver Function Tests and Acute Kidney Injury in Cardiac Surgery Patients

NCT06730854 | Completed

• 1 other identifier: ONZ-2024-0453
• Study Type: observational
• Target: 3,415
• Locations: 1 country
• Sites: 1

Brief Summary

A sudden decline in function of the kidneys is a common problem that can happen after heart surgery. It can have serious effects on a patient's recovery and long-term health, potentially leading to permanent kidney problems or heart-related issues. One of the main reasons kidney problems occurs is due to changes in blood flow caused by the heart not pumping well enough. These changes may harm the kidneys, but other organs as well such as the liver. This study aims to find out if there is a relationship between elevated levels of liver function blood tests and the decline in kidney function.

Conditions

Cardiac Surgery Associated - Acute Kidney Injury; Acute Kidney Injury

Keywords

liver enzymes; acute kidney injury; cardiac surgery

Outcome Measures

Primary Outcomes (1)

• Association between liver enzymes and acute kidney injury

  Investigation of the association between liver enzymes (alanine aminotransferase (AST); aspartate aminotransferase (ALT)) and development of acute kidney injury. Data about liver enzymes will be collected at ICU admission, and 12 hours and 24 hours after ICU admission. AKI is defined by the Kidney Disease Improving global outcome definition by using both the serum creatinine and urine output criteria.

  Data about liver enzymes will be collected at ICU admission, and 12 hours and 24 hours after ICU admission. The occurrence of acute kidney injury within 72 hours after ICU admission will be investigated

Secondary Outcomes (2)

• Association between liver enzymes and the severity of acute kidney injury

  Data about liver enzymes will be collected at ICU admission, and 12 hours and 24 hours after ICU admission. The occurrence of the different severity stages of acute kidney injury within 72 hours after ICU admission will be investigated

• association of central venous pressure with elevated liver enzymes and acute kidney injury

  Data about central venous pressure will be collected during the first 24 hours after ICU admission.

Study Arms (1)

Main cohort of patient

In the included patients the occurrence of acute kidney injury (AKI) will be investigated. So patient will be grouped as 'no AKI' and 'AKI' For the subanalysis, patient will be grouped according to their admission central venous pressure. There are no interventions.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The cardiac surgery patients screened for eligibility were admitted on the cardiac surgery intensive care unit of Ghent University hospital between 1 Januari 2012 until 31 december 2017

You may qualify if:

• years old or older
• admission on intensive care after cardiac surgery
• available data about liver enzymes

You may not qualify if:

• chronic kidney disease with (estimated) glomerular filtration rate below 30mL/min/1.73 m2 or renal replacement therapy (RRT) dependent
• patient on extracorporal membrane oxygenator (ECMO) before or after cardiac surgery
• patient with or planned surgery for Left ventricular assist device (LVAD)
• inotropics or vasopressore before surgery

Sponsors & Collaborators

• University Hospital, Ghent: lead

Study Sites (1)

Ghent university hospital

Ghent, Oost-Vlaanderen, 9000, Belgium

Location

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Wim Vandenberghe, MD; PhD

  University Hospital, Ghent

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 26, 2024
• First Posted: December 12, 2024
• Study Start: November 6, 2024
• Primary Completion: November 6, 2024
• Study Completion: November 6, 2024
• Last Updated: December 12, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)