Pilot Trial: Bioavailability Animal vs. Plant Protein Drink

NCT06465004 | Recruiting DMC

• 1 other identifier: 2024-00151
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

A pilot study is being conducted to compare a new plant-based protein drink to commercially available animal-based protein drinks. The goal is to assess if the plant-based drink delivers amino acids to the bloodstream as effectively as the animal-based drinks, potentially offering a viable option for those on plant-based diets. The study will involve approximately 12 healthy adults aged 18-40. Each participant will try all three drinks (the new plant-based drink, a commercial animal-based drink, and another animal-based recipe) on separate days in a randomized order. Before and after (30, 60, and 90 minutes) consuming each drink, a small blood sample will be drawn to measure amino acid levels (leucine). By comparing the results, the investigators hope to determine if the plant-based drink can match the effectiveness of animal-based protein drinks in delivering essential nutrients. This research could contribute to the development of sustainable and nutritious plant-based protein alternatives.

Conditions

Nutrition, Healthy; Leucine Sensitivity

Keywords

Leucin; Plant-based; Animal-based; Bioavailability

Outcome Measures

Primary Outcomes (1)

• leucine content in the blood

  Assessment of leucine content in blood before and 30-60-90 min after consumption of drink

  4 hours

Study Arms (3)

Animal-based A

ACTIVE COMPARATOR

A commercially available high protein drink, based on animal proteins (Fresubin Protein Energy)

Dietary Supplement: Consumption of protein - rich drink

Animal-based B

ACTIVE COMPARATOR

A homemade drink containing animal-based proteins, using a specific animal-based protein isolate mix.

Dietary Supplement: Consumption of protein - rich drink

Plant-based A

ACTIVE COMPARATOR

A homemade drink containing plant-based proteins, formulated to have the same macronutrient content as the animal-based drinks.

Dietary Supplement: Consumption of protein - rich drink

Interventions

Consumption of protein - rich drink DIETARY_SUPPLEMENT

The participants will drink on of three protein - rich drinks

Animal-based A; Animal-based B; Plant-based A

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Gender: male and female
• Age: 18-40 years
• Signed written informed consent

You may not qualify if:

• Smoking history
• Cardiovascular diseases
• BMI \> 35 kg/m2
• Caffeine consumption \< 1 day before the study participation
• Allergies: Soy, Peas, Milk, Lactose, Fructose
• High intensity exercise \<2 days before study participation

Sponsors & Collaborators

• ETH Zurich: lead

Study Sites (1)

SLA - ETH Zurich

Schwerzenbach, Canton of Zurich, 8603, Switzerland

RECRUITING

Study Officials

• Gommaar D'Hulst, PhD

  ETH Zurich

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Gommaar D'Hulst, PhD

CONTACT

+41786624474; gommaar-dhulst@ethz.ch

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized cross-over design

Study Record Dates

• First Submitted: June 13, 2024
• First Posted: June 18, 2024
• Study Start: June 8, 2024
• Primary Completion: June 28, 2024
• Study Completion: August 30, 2024
• Last Updated: June 21, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)