EFFECTS OF L-ARGININE SUPPLEMENTATION ON THE RECOVERY OF CARDIORESPIRATORY PARAMETERS AFTER SUBMAXIMAL EXERCISE TEST

NCT06405477 | Recruiting

• 1 other identifier: LargExBr
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

L-Arginine is an amino acid capable of stimulating the production of nitric oxide (NO) metabolites. NO is responsible for several important activities of the body, such as: helping to regulate vasodilation, blood flow, mitochondrial respiration, platelet function and increasing growth hormone levels, but the effects on the recovery of cardiorespiratory parameters after exercise testing maximum need to be clarified.

Conditions

Nutrition, Healthy

Outcome Measures

Primary Outcomes (1)

• Autonomic Nervous System

  Heart Rate Variability

  10 minutes previous to exercise and 20 minutes after exercise.

Secondary Outcomes (3)

• Blood Pressure

  10 minutes previous to exercise and 20 minutes after exercise.

• Heart Rate

  10 minutes previous to exercise and 20 minutes after exercise.

• Oxygen Saturation

  10 minutes previous to exercise and 20 minutes after exercise.

Study Arms (2)

Sun

EXPERIMENTAL

We are blind and don't know which group is which.

Dietary Supplement: L-arginine; Dietary Supplement: Placebo

Moon

PLACEBO COMPARATOR

We are blind and don't know which group is which.

Dietary Supplement: L-arginine; Dietary Supplement: Placebo

Interventions

L-arginine DIETARY_SUPPLEMENT

Capsules of 3 grams of L-arginine per Dose

Moon; Sun

Placebo DIETARY_SUPPLEMENT

Capsules of 3 grams of maize Starch per Dose

Moon; Sun

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male, aged between 18 and 30 years, body mass index (BMI) between 18.5 and 29.9 kg/m2 and physically active according to the international physical activity questionnaire

You may not qualify if:

• Individuals who are sedentary and insufficiently active according to the IPAQ questionnaire, who present cardiorespiratory, neurological, renal, endocrine, metabolic, musculoskeletal disorders and other known or reported impairments that prevent the subject from performing the procedures, smokers, alcohol drinkers, users of medications that influence the autonomic nervous system and individuals with systolic pressure greater than 130 mmHg and diastolic pressure greater than 85 mmHg at rest

Sponsors & Collaborators

• Universidade Estadual Paulista Júlio de Mesquita Filho: lead

Study Sites (1)

UNESP

Presidente Prudente, São Paulo, 19060-900, Brazil

RECRUITING

MeSH Terms

Interventions

Arginine

Intervention Hierarchy (Ancestors)

Amino Acids, Basic; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Diamino; Amino Acids, Essential

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: April 26, 2024
• First Posted: May 8, 2024
• Study Start: February 15, 2024
• Primary Completion: May 30, 2024
• Study Completion: August 15, 2024
• Last Updated: May 8, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)