Aminoacidemia and Protein Kinetics in Response to the Ingestion of Plant-based Protein Blends

NCT05139160 | Active Not Recruiting

• 1 other identifier: 14040
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

The present investigation aims to study a novel plant based protein isolate blend to determine if it results in similar muscle building responses compared to whey protein isolate.

Conditions

Nutrition, Healthy

Keywords

plant-based protein; whey protein; protein quality; muscle protein synthesis

Outcome Measures

Primary Outcomes (1)

• Muscle protein synthesis

  A marker of muscle growth

  Over a 5 hour period

Secondary Outcomes (5)

• Aminoacidemia

  Over a 5 hour period

• Appetite and desire for specific food types in response to test drinks types H

  Immediately before, and 30, 60, 120, 180 and 300 minutes after test drinks are consumed.

• Palatability of test drinks

  Immediately after test drink are consumed.

• Questionnaire on safety

  Over a 5 hour period

• Tolerability of test drinks

  Over a 5 hour period

Study Arms (3)

Whey protein isolate

EXPERIMENTAL

Whey protein isolate is the 'gold standard' of protein supplements due to being rich in essential amino acids and leucine. Leucine is a key amino acid the is required to stimulate muscle protein synthesis. Muscle protein synthesis is the major mechanism the underpins muscle growth. The whey protein would ostensibly serve as a positive control.

Dietary Supplement: Protein quality

Plant based protein isolate

EXPERIMENTAL

Current plant-based protein isolates available contain insufficient amounts of leucine, and are less digestible, resulting in a reduced muscle protein synthesis responses. The plant based protein would ostensibly serve as a negative control.

Dietary Supplement: Protein quality

Plant based protein isolate + leucine

EXPERIMENTAL

Enriching plant-based protein with leucine will increase the 'quality' of said protein source and theoretically should have similar muscle protein synthetic responses to whey protein.

Dietary Supplement: Protein quality

Interventions

Protein quality DIETARY_SUPPLEMENT

the present investigation aims to study a novel protein based protein isolate blend with and without leucine an compared with whey protein isolate to determine its impact aminoacidemia and muscle protein synthesis healthy adults.

Plant based protein isolate; Plant based protein isolate + leucine; Whey protein isolate

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female, between the ages of 18 - 30 years (inclusive)
• Have a body mass index (BMI) between 18-30 kg·m2 (inclusive)
• Be in general good health as assessed by a general health questionnaire
• Non-smoking
• Regular menstrual cycle and not using hormonal contraceptives
• Willing and able to provide informed consent

You may not qualify if:

• Currently using analgesic or anti-inflammatory drugs
• A history of neuromuscular problems or muscle and/or bone wasting diseases
• Any acute or chronic illness, metabolic disorders
• Currently using corticosteroids
• Use of hormonal contraceptives or anabolic steroids (e.g. testosterone)

Sponsors & Collaborators

• McMaster University: lead

Study Sites (1)

Changhyun Lim

Hamilton, Ontario, L8S 4K1, Canada

Location

Related Publications (1)

• Lim C, Janssen TAH, Currier BS, Paramanantharajah N, McKendry J, Abou Sawan S, Phillips SM. Muscle Protein Synthesis in Response to Plant-Based Protein Isolates With and Without Added Leucine Versus Whey Protein in Young Men and Women. Curr Dev Nutr. 2024 May 10;8(6):103769. doi: 10.1016/j.cdnut.2024.103769. eCollection 2024 Jun.

  PMID: 38846451 DERIVED

Study Officials

• Stuart Phillips, PhD

  McMaster University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: The study design will be a randomized, double blind, crossover trial.
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: The study design will be a randomized, double blind, crossover trial.

Study Record Dates

• First Submitted: November 9, 2021
• First Posted: December 1, 2021
• Study Start: August 15, 2022
• Primary Completion: April 1, 2023
• Study Completion: July 10, 2025
• Last Updated: October 8, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)