NCT06318169

Brief Summary

The study will assess the efficacy and safety of 2 dose regimens of pegozafermin compared to placebo for the treatment of liver fibrosis stage F2 or F3 in adult participants with MASH.

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
1,350

participants targeted

Target at P75+ for phase_3

Timeline
34mo left

Started Mar 2024

Longer than P75 for phase_3

Geographic Reach
26 countries

332 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress44%
Mar 2024Feb 2029

First Submitted

Initial submission to the registry

March 13, 2024

Completed
Same day until next milestone

Study Start

First participant enrolled

March 13, 2024

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 19, 2024

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2029

Last Updated

May 5, 2026

Status Verified

May 1, 2026

Enrollment Period

4.9 years

First QC Date

March 13, 2024

Last Update Submit

May 4, 2026

Conditions

Keywords

Liver DiseasesFatty LiverDigestive System DiseasesMetabolic diseasesMetabolic Dysfunction-Associated SteatohepatitisMASHSteatohepatitisMetabolic dysfunction-associated steatotic liver diseaseMASLDNonalcoholic fatty liver diseaseNAFLDFibrosis

Outcome Measures

Primary Outcomes (3)

  • Number of Participants With at Least an Improvement of Fibrosis ≥1 Stage Without Worsening of Steatohepatitis at Week 52

    Worsening of steatohepatitis is defined as increase in non-alcoholic fatty liver disease (NAFLD) Activity Score (NAS) for ballooning, inflammation, or steatosis

    Week 52

  • Number of Participants With Resolution of Steatohepatitis Without Worsening of Fibrosis at Week 52

    Resolution of steatohepatitis is defined as total absence of ballooning (score=0) and absent or mild inflammation (score 0 to 1). Worsening of fibrosis is defined as progression of fibrosis by ≥1 stage.

    Week 52

  • Time to First Occurrence of Disease Progression

    Final analysis of the time to first occurrence of disease progression will be measured by a composite of protocol-specified clinical events

    Up to 5 years

Secondary Outcomes (2)

  • Percent Change from Baseline in Alanine Aminotransferase at Week 52

    Baseline, Week 52

  • Absolute Change From Baseline in Enhanced Liver Fibrosis (ELF) Score at Week 52

    Baseline, Week 52

Study Arms (3)

Pegozafermin Regimen 1

EXPERIMENTAL
Biological: Pegozafermin

Pegozafermin Regimen 2

EXPERIMENTAL
Biological: Pegozafermin

Placebo

PLACEBO COMPARATOR

Matched Placebo will be administered in Regimens 1 and 2.

Other: Placebo

Interventions

PegozaferminBIOLOGICAL

Subcutaneous injection

Also known as: BIO89-100
Pegozafermin Regimen 1Pegozafermin Regimen 2
PlaceboOTHER

Subcutaneous injection

Placebo

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Males or non-pregnant females aged between 18 and 80 years (inclusive) at time of signing the informed consent form (ICF)
  • Biopsy-confirmed MASH with fibrosis stage F2 or F3
  • Body mass index (BMI) at screening ≥25.0 kilograms (kg)/meters squared (m\^2) (≥23 kg/m\^2 for Asian participants).

You may not qualify if:

  • Chronic liver diseases other than MASH
  • Evidence of cirrhosis on screening liver biopsy
  • Have type 1 diabetes or poorly controlled type 2 diabetes
  • Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥250 units per liter (U/L)
  • Participants taking vitamin E (\>400 international units \[IU\]/day) or pioglitazone must be on stable dose for at least 6 months prior to Screening

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (342)

89bio Clinical Study Site

Birmingham, Alabama, 35209, United States

RECRUITING

89bio Clinical Study Site

Chandler, Arizona, 85224, United States

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89bio Clinical Study Site

Flagstaff, Arizona, 86001, United States

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89bio Clinical Study Site

Glendale, Arizona, 85036, United States

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89bio Clinical Study Site

Tucson, Arizona, 85712, United States

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89bio Clinical Study Site

Conway, Arkansas, 72032, United States

TERMINATED

89bio Clinical Study Site

Little Rock, Arkansas, 72211-3859, United States

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89bio Clinical Study Site

North Little Rock, Arkansas, 72117, United States

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89bio Clinical Study Site

Canoga Park, California, 91604, United States

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89bio Clinical Study Site

Coronado, California, 92118, United States

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89bio Clinical Study Site

Fountain Valley, California, 92708, United States

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89bio Clinical Study Site

Fresno, California, 93720, United States

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89bio Clinical Study Site

Gardena, California, 90247, United States

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89bio Clinical Study Site

Huntington Park, California, 90255, United States

TERMINATED

89bio Clinical Study Site

Inglewood, California, 90301, United States

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89bio Clinical Study Site

La Jolla, California, 92037, United States

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89bio Clinical Study Site

Lancaster, California, 93534, United States

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89bio Clinical Study Site

Long Beach, California, 90815, United States

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89bio Clinical Study Site

Los Angeles, California, 90048, United States

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89bio Clinical Study Site

Montclair, California, 91763, United States

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89bio Clinical Study Site

Orange, California, 92868, United States

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89bio Clinical Study Site

Panorama City, California, 91402, United States

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89bio Clinical Study Site

Pasadena, California, 91105, United States

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89bio Clinical Study Site

Poway, California, 92064, United States

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89bio Clinical Study Site

Rialto, California, 92377, United States

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89bio Clinical Study Site

Santa Ana, California, 92704-5763, United States

TERMINATED

89bio Clinical Study Site

Stanford, California, 94305, United States

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89bio Clinical Study Site

Victorville, California, 92395, United States

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89bio Clinical Study Site

Colorado Springs, Colorado, 80923, United States

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89bio Clinical Study Site

Littleton, Colorado, 80120, United States

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89bio Clinical Study Site

Brandon, Florida, 33511, United States

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89bio Clinical Study Site

Clermont, Florida, 34711, United States

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89bio Clinical Study Site

Fort Myers, Florida, 33912, United States

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89bio Clinical Study Site

Hialeah Gardens, Florida, 33016, United States

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89bio Clinical Study Site

Homestead, Florida, 33030, United States

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89bio Clinical Study Site

Jacksonville, Florida, 32256, United States

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89bio Clinical Study Site

Jupiter, Florida, 33458, United States

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89bio Clinical Study Site

Lady Lake, Florida, 32159-6831, United States

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89bio Clinical Study Site

Lady Lake, Florida, 32159-8986, United States

TERMINATED

89bio Clinical Study Site

Lakewood Rch, Florida, 34211, United States

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89bio Clinical Study Site

Lehigh Acres, Florida, 33936, United States

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89bio Clinical Study Site

Maitland, Florida, 32751-7258, United States

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89bio Clinical Study Site

Maitland, Florida, 32751-7497, United States

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89bio Clinical Study Site

New Port Richey, Florida, 34653, United States

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89bio Clinical Study Site

Ocala, Florida, 34471, United States

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89bio Clinical Study Site

Ocoee, Florida, 34761, United States

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89bio Clinical Study Site

Sarasota, Florida, 34240, United States

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89bio Clinical Study Site

Winter Park, Florida, 32789, United States

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89bio Clinical Study Site

Athens, Georgia, 30607, United States

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89bio Clinical Study Site

Dalton, Georgia, 30720, United States

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89bio Clinical Study Site

Chicago, Illinois, 60611, United States

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89bio Clinical Study Site

Hammond, Indiana, 46324, United States

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89bio Clinical Study Site

New Albany, Indiana, 47150, United States

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89bio Clinical Study Site

South Bend, Indiana, 46635, United States

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89bio Clinical Study Site

Iowa City, Iowa, 52242, United States

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89bio Clinical Study Site

Topeka, Kansas, 66606, United States

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89bio Clinical Study Site

Covington, Louisiana, 70433, United States

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89bio Clinical Study Site

Houma, Louisiana, 70360, United States

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89bio Clinical Study Site

Lake Charles, Louisiana, 70605, United States

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89bio Clinical Study Site

Marrero, Louisiana, 70072, United States

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89bio Clinical Study Site

New Orleans, Louisiana, 70115, United States

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89bio Clinical Study Site

West Monroe, Louisiana, 71291, United States

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89bio Clinical Study Site

Baltimore, Maryland, 21202, United States

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89bio Clinical Study Site

Glen Burnie, Maryland, 21061, United States

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89bio Clinical Study Site

Greenbelt, Maryland, 20770, United States

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89bio Clinical Study Site

Burlington, Massachusetts, 01805, United States

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89bio Clinical Study Site

Chesterfield, Michigan, 48047, United States

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89bio Clinical Study Site

Wyoming, Michigan, 49519, United States

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89bio Clinical Study Site

Ypsilanti, Michigan, 48197, United States

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89bio Clinical Study Site

Rochester, Minnesota, 55905, United States

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89bio Clinical Study Site

Flowood, Mississippi, 39232, United States

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89bio Clinical Study Site

St Louis, Missouri, 63123, United States

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89bio Clinical Study Site

Las Vegas, Nevada, 89106, United States

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89bio Clinical Study Site

Florham Park, New Jersey, 07932, United States

TERMINATED

89bio Clinical Study Site

Freehold, New Jersey, 07728, United States

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89bio Clinical Study Site

Warren Township, New Jersey, 07059, United States

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89bio Clinical Study Site

Albuquerque, New Mexico, 87109, United States

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89bio Clinical Study Site

Carmel, New York, 10512, United States

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89bio Clinical Study Site

New York, New York, 10021, United States

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89bio Clinical Study Site

New York, New York, 10033, United States

TERMINATED

89bio Clinical Study Site

Charlotte, North Carolina, 28207, United States

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89bio Clinical Study Site

Durham, North Carolina, 27710, United States

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89bio Clinical Study Site

Fayetteville, North Carolina, 28304, United States

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89bio Clinical Study Site

Morehead City, North Carolina, 28557, United States

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89bio Clinical Study Site

Raleigh, North Carolina, 27612, United States

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89bio Clinical Study Site

Winston-Salem, North Carolina, 27103, United States

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89bio Clinical Study Site

Akron, Ohio, 44320, United States

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89bio Clinical Study Site

Cleveland, Ohio, 44106, United States

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89bio Clinical Study Site

Dayton, Ohio, 45414, United States

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89bio Clinical Study Site

Liberty Township, Ohio, 45044, United States

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89bio Clinical Study Site

Lima, Ohio, 45801, United States

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89bio Clinical Study Site

Springboro, Ohio, 45066, United States

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89bio Clinical Study Site

Westlake, Ohio, 44145, United States

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89bio Clinical Study Site

East Greenwich, Rhode Island, 02818, United States

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89bio Clinical Study Site

Charleston, South Carolina, 29425, United States

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89bio Clinical Study Site

Columbia, South Carolina, 29204, United States

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89bio Clinical Study Site

Chattanooga, Tennessee, 37421, United States

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89bio Clinical Study Site

Cordova, Tennessee, 38018, United States

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89bio Clinical Study Site

Hermitage, Tennessee, 37076, United States

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89bio Clinical Study Site

Nashville, Tennessee, 37211, United States

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89bio Clinical Study Site

Amarillo, Texas, 79106, United States

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89bio Clinical Study Site

Austin, Texas, 78745, United States

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89bio Clinical Study Site

Austin, Texas, 78757-8051, United States

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89bio Clinical Study Site

Austin, Texas, 78757, United States

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89bio Clinical Study Site

Bellaire, Texas, 77401, United States

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89bio Clinical Study Site

Brownsville, Texas, 78520, United States

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89bio Clinical Study Site

Corpus Christi, Texas, 78404, United States

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89bio Clinical Study Site

DeSoto, Texas, 75115, United States

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89bio Clinical Study Site

Edinburg, Texas, 78539, United States

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89bio Clinical Study Site

Farmers Branch, Texas, 75234, United States

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89bio Clinical Study Site

Fort Sam Houston, Texas, 78234, United States

TERMINATED

89bio Clinical Study Site

Fort Worth, Texas, 76104, United States

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89bio Clinical Study Site

Garland, Texas, 75044, United States

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89bio Clinical Study Site

Georgetown, Texas, 78626, United States

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89bio Clinical Study Site

Georgetown, Texas, 78628, United States

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89bio Clinical Study Site

Houston, Texas, 77030, United States

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89bio Clinical Study Site

Houston, Texas, 77099, United States

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89bio Clinical Study Site

Katy, Texas, 77494, United States

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89bio Clinical Study Site

San Antonio, Texas, 78209, United States

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89bio Clinical Study Site

San Antonio, Texas, 78215, United States

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89bio Clinical Study Site

San Antonio, Texas, 78222, United States

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89bio Clinical Study Site

San Antonio, Texas, 78229-4801, United States

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89bio Clinical Study Site

San Antonio, Texas, 78229, United States

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89bio Clinical Study Site

Stafford, Texas, 77477, United States

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89bio Clinical Study Site

Tomball, Texas, 77584, United States

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89bio Clinical Study Site

Waco, Texas, 76301, United States

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89bio Clinical Study Site

Waco, Texas, 76710, United States

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89bio Clinical Study Site

Ogden, Utah, 84405, United States

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89bio Clinical Study Site

Richmond, Virginia, 23226-1925, United States

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89bio Clinical Study Site

Richmond, Virginia, 23229, United States

TERMINATED

89bio Clinical Study Site

Richmond, Virginia, 23236, United States

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89bio Clinical Study Site

Richmond, Virginia, 23298, United States

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89bio Clinical Study Site

Roanoke, Virginia, 24014, United States

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89bio Clinical Study Site

Seattle, Washington, 98101, United States

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89bio Clinical Study Site

Seattle, Washington, 98105, United States

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89bio Clinical Study Site

Buenos Aires, 1061, Argentina

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89bio Clinical Study Site

Buenos Aires, 1125, Argentina

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89bio Clinical Study Site

Buenos Aires, 1181, Argentina

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89bio Clinical Study Site

Buenos Aires, C1012AAR, Argentina

TERMINATED

89bio Clinical Study Site

Buenos Aires, C1425, Argentina

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89bio Clinical Study Site

Caba, C1430CKE, Argentina

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89bio Clinical Study Site

Capital Federal, C1280AEB, Argentina

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89bio Clinical Study Site

Pilar, 1629, Argentina

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89bio Clinical Study Site

Brisbane, Queensland, 4120, Australia

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89bio Clinical Study Site

Herston, Queensland, 4019, Australia

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89bio Clinical Study Site

South Brisbane, Queensland, 4101, Australia

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89bio Clinical Study Site

Adelaide, South Australia, 5000, Australia

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89bio Clinical Study Site

Bedford Park, South Australia, 5042, Australia

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89bio Clinical Study Site

Clayton, Victoria, 3168, Australia

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89bio Clinical Study Site

Heidelberg, Victoria, 3084, Australia

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89bio Clinical Study Site

Perth, Western Australia, 6000, Australia

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89bio Clinical Study Site

Fitzroy, 3065, Australia

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89bio Clinical Study Site

Murdoch, 6150, Australia

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89bio Clinical Study Site

Graz, 8036, Austria

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89bio Clinical Study Site

Innsbruck, 6020, Austria

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89bio Clinical Study Site

Klagenfurt, 9020, Austria

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89bio Clinical Study Site

Sankt Pölten, 3100, Austria

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89bio Clinical Study Site

Wels, 4600, Austria

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89bio Clinical Study Site

Brussels, 1020, Belgium

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89bio Clinical Study Site

Brussels, 1070, Belgium

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89bio Clinical Study Site

Edegem, 2650, Belgium

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89bio Clinical Study Site

Genk, 3600, Belgium

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89bio Clinical Study Site

Ghent, 9000, Belgium

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89bio Clinical Study Site

Jette, 1090, Belgium

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89bio Clinical Study Site

Gorna Oryahovitsa, 5100, Bulgaria

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89bio Clinical Study Site

Sofia, 1202, Bulgaria

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89bio Clinical Study Site

Sofia, 1407, Bulgaria

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89bio Clinical Study Site

Sofia, 1431, Bulgaria

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89bio Clinical Study Site

Stara Zagora, 6003, Bulgaria

TERMINATED

89bio Clinical Study Site

Calgary, Alberta, T2N 4Z6, Canada

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89bio Clinical Study Site

Vancouver, British Columbia, V5Z 1M9, Canada

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89bio Clinical Study Site

Vancouver, British Columbia, V6Z2K5, Canada

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89bio Clinical Study Site

Winnipeg, Manitoba, R3T 2N2, Canada

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89bio Clinical Study Site

London, Ontario, N6A 5A5, Canada

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89bio Clinical Study Site

Ottawa, Ontario, K1H8L6, Canada

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89bio Clinical Study Site

Toronto, Ontario, M5G2C4, Canada

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89bio Clinical Study Site

Toronto, Ontario, M6H 3M1, Canada

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89bio Clinical Study Site

Vaughan, Ontario, L4L 4Y7, Canada

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89bio Clinical Study Site

Brno, 625 00, Czechia

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89bio Clinical Study Site

Ostrava, 708 52, Czechia

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89bio Clinical Study Site

Pilsen, 30100, Czechia

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89bio Clinical Study Site

Amiens, 80080, France

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89bio Clinical Study Site

Angers, 49933, France

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89bio Clinical Study Site

Bordeaux, 33604, France

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89bio Clinical Study Site

Lille, 59000, France

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89bio Clinical Study Site

Limoges, 87042, France

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89bio Clinical Study Site

Lyon, 69004, France

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89bio Clinical Study Site

Montpellier, 34090, France

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89bio Clinical Study Site

Nantes, 44093, France

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89bio Clinical Study Site

Nice, 06200, France

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89bio Clinical Study Site

Paris, 75012, France

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89bio Clinical Study Site

Paris, 75013, France

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89bio Clinical Study Site

Paris, 75014, France

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89bio Clinical Study Site

Pierre-Bénite, 69310, France

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89bio Clinical Study Site

Strasbourg, 67000, France

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89bio Clinical Study Site

Toulouse, 31076, France

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89bio Clinical Study Site

Toulouse, France

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89bio Clinical Study Site

Vandœuvre-lès-Nancy, 54500, France

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89bio Clinical Study Site

Vénissieux, 69200, France

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89bio Clinical Study Site

Villejuif, 94800, France

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89bio Clinical Study Site

Batumi, 6000, Georgia

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89bio Clinical Study Site

Batumi, 6010, Georgia

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89bio Clinical Study Site

Tbilisi, 0159, Georgia

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89bio_Clinical Study Site

Tbilisi, 0159, Georgia

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89bio Clinical Study Site

Tbilisi, 0177, Georgia

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89bio Clinical Study Site

Chemnitz, 09116, Germany

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89bio Clinical Study Site

Frankfurt am Main, 60596, Germany

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89bio Clinical Study Site

Freiburg im Breisgau, 79106, Germany

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89bio Clinical Study Site

Hanover, 30625, Germany

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89bio Clinical Study Site

Homburg, 66421, Germany

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89bio Clinical Study Site

Münster, 48149, Germany

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89bio Clinical Study Site

Hong Kong, 0000, Hong Kong

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89bio Clinical Study Site

Shatin, 0000, Hong Kong

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89bio Clinical Study Site

Guwahati, Assam, 701032, India

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89bio Clinical Study Site

Kolkata, West Bengal, 700150, India

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89bio Clinical Study Site

Bhubaneswar, 751024, India

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89bio Clinical Study Site

Gujrāt, 360001, India

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89bio Clinical Study Site

Nagpur, 440012, India

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89bio Clinical Study Site

Wardha, 442004, India

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89bio Clinical Study Site

Afula, 1834111, Israel

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89bio Clinical Study Site

Beersheba, 8410500, Israel

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89bio Clinical Study Site

Haifa, 3109601, Israel

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89bio Clinical Study Site

Haifa, 3436212, Israel

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89bio Clinical Study Site

Jerusalem, Israel

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89bio Clinical Study Site

Nahariya, 2210001, Israel

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89bio Clinical Study Site

Petah Tikva, 4941492, Israel

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89bio Clinical Study Site

Ramat Gan, 52621, Israel

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89bio Clinical Study Site

Tel Aviv, 6971014, Israel

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89bio Clinical Study Site

Tel Aviv, Israel

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89bio Clinical Study Site

Bergamo, 24127, Italy

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89bio Clinical Study Site

Milan, 20089, Italy

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89bio Clinical Study Site

Milan, 20152, Italy

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89bio Clinical Study Site

Milan, 20162, Italy

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89bio Clinical Study Site

Modena, 41126, Italy

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89bio Clinical Study Site

Naples, 80131, Italy

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89bio Clinical Study Site

Novara, 28100, Italy

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89bio Clinical Study Site

Palermo, 90127, Italy

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89bio Clinical Study Site

Roma, 00128, Italy

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89bio Clinical Study Site

Rome, 00136, Italy

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89bio Clinical Study Site

Rome, 169, Italy

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89bio Clinical Study Site

Torino, 10126, Italy

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89bio Clinical Study Site

Maebashi, Gunma, 371-0821, Japan

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89bio Clinical Study Site

Sapporo, Hokkaido, 065-0012, Japan

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89bio Clinical Study Site

Hizume, Iwate, 028-3695, Japan

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89bio Clinical Study Site

Kawasaki, Kanagawa, 215-0026, Japan

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89bio Clinical Study Site

Yokohama, Kanagawa, 236-004, Japan

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89bio Clinical Study Site

Ehime, 791-0295, Japan

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89bio Clinical Study Site

Ehime, 798-8510, Japan

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89bio Clinical Study Site

Fukuoka, 814-0180, Japan

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89bio Clinical Study Site

Gifu, 500-8323, Japan

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89bio Clinical Study Site

Kumamoto, 862-0971, Japan

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89bio Clinical Study Site

Nagano, 381-0006, Japan

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89bio Clinical Study Site

Okayama, 700-8558, Japan

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89bio Clinical Study Site

Osaka, 545-0051, Japan

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89bio Clinical Study Site

Osaka, 564-0013, Japan

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89bio Clinical Study Site

Saga, 849-0937, Japan

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89bio Clinical Study Site

Sapporo, 062-0921, Japan

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89bio Clinical Study Site

Chihuahua City, 31217, Mexico

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89bio Clinical Study Site

Cuautitlán Izcalli, 54769, Mexico

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89bio Clinical Study Site

Jalisco, 44130, Mexico

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89bio Clinical Study Site

Mexico City, 03330, Mexico

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89bio Clinical Study Site

Mexico City, 06700, Mexico

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89bio Clinical Study Site

Morelos, 62270, Mexico

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89bio Clinical Study Site

Nuevo León, 64310, Mexico

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89bio Clinical Study Site

Yucatán, 97070, Mexico

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89bio Clinical Study Site

Rotterdam, South Holland, 3015C, Netherlands

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89bio Clinical Study Site

Amsterdam, 1081HV, Netherlands

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89bio Clinical Study Site

Utrecht, 3584CX, Netherlands

RECRUITING

89bio Clinical Study Site

Katowice, 40-752, Poland

WITHDRAWN

89bio Clinical Study Site

Krakow, 31-501, Poland

RECRUITING

89bio Clinical Study Site

Lodz, 90-302, Poland

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89bio Clinical Study Site

Lodz, 91-363, Poland

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89bio Clinical Study Site

Mysłowice, 41-400, Poland

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89bio Clinical Study Site

Warsaw, 00-215, Poland

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89bio Clinical Study Site

Warsaw, 02-172, Poland

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89bio Clinical Study Site

Warsaw, 04-501, Poland

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89bio Clinical Study Site

Wroclaw, 53-673, Poland

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89bio Clinical Study Site

Manati, 00674, Puerto Rico

RECRUITING

89bio Clinical Study Site

Mayagüez, 00680, Puerto Rico

RECRUITING

89bio Clinical Study Site

San Juan, 00927, Puerto Rico

RECRUITING

89bio Clinical Study Site

Singapore, 119228, Singapore

RECRUITING

89bio Clinical Study Site

Singapore, 169856, Singapore

RECRUITING

89bio Clinical Study Site

Singapore, 308433, Singapore

RECRUITING

89bio Clinical Study Site

Singapore, 529889, Singapore

RECRUITING

89bio Clinical Study Site

Cape Town, 7530, South Africa

RECRUITING

89bio Clinical Study Site

Johannesburg, 2196, South Africa

RECRUITING

89bio Clinical Study Site

Worcester, 6850, South Africa

RECRUITING

89bio Clinical Study Site

Busan, 49241, South Korea

RECRUITING

89bio Clinical Study Site

Daegu, 42415, South Korea

RECRUITING

89bio Clinical Study Site

Gyeonggi-do, 16247, South Korea

RECRUITING

89bio Clinical Study Site

Incheon, 22332, South Korea

RECRUITING

89bio Clinical Study Site

Seoul, 02447, South Korea

RECRUITING

89bio Clinical Study Site

Seoul, 03080, South Korea

RECRUITING

89bio Clinical Study Site

Seoul, 06591, South Korea

RECRUITING

89bio Clinical Study Site

Seoul, 07061, South Korea

RECRUITING

89bio Clinical Study Site

Seoul, 07985, South Korea

RECRUITING

89bio Clinical Study Site

Seoul, 08308, South Korea

RECRUITING

89bio Clinical Study Site

Barcelona, 08003, Spain

RECRUITING

89bio Clinical Study Site

Barcelona, 08035, Spain

RECRUITING

89bio Clinical Study Site

Barcelona, 08036, Spain

RECRUITING

89bio Clinical Study Site

Barcelona, 08041, Spain

RECRUITING

89bio Clinical Study Site

Barcelona, 08916, Spain

RECRUITING

89bio Clinical Study Site

Córdoba, 14004, Spain

RECRUITING

89bio Clinical Study Site

Madrid, 28007, Spain

RECRUITING

89bio Clinical Study Site

Majadahonda, 28222, Spain

RECRUITING

89bio Clinical Study Site

Málaga, 29010, Spain

WITHDRAWN

89bio Clinical Study Site

Pontevedra, 36071, Spain

RECRUITING

89bio Clinical Study Site

Santander, 39008, Spain

RECRUITING

89bio Clinical Study Site

Santiago de Compostela, 15706, Spain

RECRUITING

89bio Clinical Study Site

Seville, 41013, Spain

RECRUITING

89bio Clinical Study Site

Chiayi City, 60002, Taiwan

RECRUITING

89bio Clinical Study Site

Kaohsiung City, 807, Taiwan

RECRUITING

89bio Clinical Study Site

Taipei, 100225, Taiwan

RECRUITING

89bio Clinical Study Site

Adana, 1370, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Ankara, 06230, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Ankara, 06800, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Bursa, 16110, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Center, 53020, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Fatih, 34093, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Gaziantep, 27410, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Istanbul, 34010, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Istanbul, 34899, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Izmir, 35360, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Sarıçam, 01790, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Umraniye, 34764, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

High Wycombe, Buckinghamshire, HP11 2QW, United Kingdom

RECRUITING

89bio Clinical Study Site

Bristol, BS6 6LT, United Kingdom

RECRUITING

89bio Clinical Study Site

Glasgow, G514TY, United Kingdom

RECRUITING

89bio Clinical Study Site

Hull, HU3 2JZ, United Kingdom

RECRUITING

89bio Clinical Study Site

London, E13 8SL, United Kingdom

RECRUITING

89bio Clinical Study Site

London, E1, United Kingdom

RECRUITING

89bio Clinical Study Site

London, NW32QG, United Kingdom

RECRUITING

89bio Clinical Study Site

London, SE5 9RS, United Kingdom

RECRUITING

89bio Clinical Study Site

London, W2 1NY, United Kingdom

RECRUITING

89bio Clinical Study Site

Oxford, OX3 9DU, United Kingdom

RECRUITING

89bio Clinical Study Site

Portsmouth, PO6 3LY, United Kingdom

RECRUITING

89bio Clinical Study Site

Preston, PR2 9QB, United Kingdom

RECRUITING

89bio Clinical Study Site

Southampton, SO16 6YD, United Kingdom

RECRUITING

89bio Clinical Study Site

Stockton, TS19, United Kingdom

RECRUITING

89bio Clinical Study Site

Sunderland, SR4 7TP, United Kingdom

RECRUITING

89bio Clinical Study Site

Swansea, SA6, United Kingdom

RECRUITING

89bio Clinical Study Site

York, YO24 4LJ, United Kingdom

RECRUITING

MeSH Terms

Conditions

Non-alcoholic Fatty Liver DiseaseLiver DiseasesFatty LiverDigestive System DiseasesMetabolic DiseasesFibrosis

Condition Hierarchy (Ancestors)

Nutritional and Metabolic DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Millie Gottwald, PharmD

    89bio, Inc.

    STUDY DIRECTOR

Central Study Contacts

ENLIGHTEN clinical trial

CONTACT

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 13, 2024

First Posted

March 19, 2024

Study Start

March 13, 2024

Primary Completion (Estimated)

February 1, 2029

Study Completion (Estimated)

February 1, 2029

Last Updated

May 5, 2026

Record last verified: 2026-05

Locations