NCT06419374

Brief Summary

The study will assess the efficacy and safety of pegozafermin administered in participants with compensated cirrhosis due to MASH (biopsy-confirmed fibrosis stage F4 MASH \[previously known as nonalcoholic steatohepatitis, NASH\]).

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
762

participants targeted

Target at P75+ for phase_3

Timeline
64mo left

Started May 2024

Longer than P75 for phase_3

Geographic Reach
23 countries

296 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress27%
May 2024Aug 2031

First Submitted

Initial submission to the registry

May 14, 2024

Completed
3 days until next milestone

First Posted

Study publicly available on registry

May 17, 2024

Completed
7 days until next milestone

Study Start

First participant enrolled

May 24, 2024

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2028

Expected
3.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2031

Last Updated

May 6, 2026

Status Verified

May 1, 2026

Enrollment Period

4 years

First QC Date

May 14, 2024

Last Update Submit

May 5, 2026

Conditions

Keywords

Liver diseaseFatty LiverDigestive System DiseasesMetabolic diseasesMetabolic Dysfunction-Associated SteatohepatitisMASHNonalcoholic steatohepatitisNASHMetabolic dysfunction-associated steatotic liver diseaseMASLDNonalcoholic fatty liver diseaseNAFLDFibrosisCirrhosis

Outcome Measures

Primary Outcomes (2)

  • Proportion of Participants Achieving Fibrosis Regression

    Fibrosis regression is defined as improvement in fibrosis by ≥1 stage, at Month 24 biopsy relative to baseline biopsy.

    Baseline through Month 24

  • Time to First Occurrence of Disease Progression as Measured by Composite of Protocol -Specified Clinical Events

    Baseline up to 5 years

Secondary Outcomes (4)

  • Change from Baseline in Enhanced Liver Fibrosis (ELF) Score

    Baseline, up to Month 60

  • Change from Baseline in Alanine Aminotransferase (ALT) Level

    Baseline, up to Month 60

  • Change from Baseline in FibroScan Vibration-controlled Transient Elastography (VCTE)

    Baseline, up to Month 60

  • Proportion of Participants who Develop Clinically Significant Portal Hypertension (CSPH)

    Baseline up to Month 60

Study Arms (2)

Pegozafermin

EXPERIMENTAL
Biological: Pegozafermin

Placebo

PLACEBO COMPARATOR

Matched placebo

Drug: Placebo

Interventions

PegozaferminBIOLOGICAL

Subcutaneous injection

Also known as: BIO89-100
Pegozafermin

Subcutaneous injection

Placebo

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Males or non-pregnant females aged between 18 and 75 years (inclusive) at time of signing the informed consent form (ICF).
  • Participants must have type 2 diabetes mellitus diagnosed at least 3 months before screening or at least 2 metabolic risk factors.
  • Biopsy-confirmed fibrosis stage F4 MASH (NASH Clinical Research Network (CRN) system) with compensated cirrhosis.
  • Body mass index (BMI) at screening ≥25.0 (≥23.0 for Asian participants) and \<50.0 kilograms (kg)/meters squared (m\^2).

You may not qualify if:

  • Liver disorder other than MASH.
  • History or evidence of hepatic decompensation.
  • History or evidence of hepatocellular carcinoma.
  • Have type 1 diabetes mellitus or poorly controlled type 2 diabetes mellitus.
  • ALT or aspartate aminotransferase (AST) ≥250 units per liter (U/L).
  • Participants taking vitamin E (\>400 international units \[IU\]/day) must be on stable dose for at least 6 months prior to screening.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (296)

89bio Clinical Study Site

Birmingham, Alabama, 35205, United States

RECRUITING

89bio Clinical Study Site

Homewood, Alabama, 35209, United States

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89bio Clinical Study Site

Chandler, Arizona, 85224, United States

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89bio Clinical Study Site

Flagstaff, Arizona, 86001, United States

WITHDRAWN

89bio Clinical Study Site

Peoria, Arizona, 85381, United States

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89bio Clinical Study Site

Phoenix, Arizona, 85054, United States

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89bio Clinical Study Site

Tucson, Arizona, 85712, United States

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89bio Clinical Study Site

Tucson, Arizona, 85715, United States

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89bio Clinical Study Site

Tucson, Arizona, 85716, United States

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89bio Clinical Study Site

Little Rock, Arkansas, 72205, United States

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89bio Clinical Study Site

North Little Rock, Arkansas, 72117, United States

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89bio Clinical Study Site

Camarillo, California, 93012, United States

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89bio Clinical Study Site

Canoga Park, California, 91304, United States

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89bio Clinical Study Site

Coronado, California, 92118, United States

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89bio Clinical Study Site

Fountain Valley, California, 92708, United States

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89bio Clinical Study Site

Fresno, California, 93720, United States

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89bio Clinical Study Site

Huntington Park, California, 90255, United States

WITHDRAWN

89bio Clinical Study Site

La Jolla, California, 92037-0887, United States

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89bio Clinical Study Site

Los Angeles, California, 90033, United States

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89bio Clinical Study Site

Los Angeles, California, 90048, United States

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89bio Clinical Study Site

Pasadena, California, 91105, United States

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89bio Clinical Study Site

Poway, California, 92064, United States

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89bio Clinical Study Site

Redwood City, California, 94063, United States

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89bio Clinical Study Site

Rialto, California, 92377, United States

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89bio Clinical Study Site

Sacramento, California, 95817, United States

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89bio Clinical Study Site

Santa Ana, California, 92704, United States

WITHDRAWN

89bio Clinical Study Site

Littleton, Colorado, 80120, United States

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89bio Clinical Study Site

Clermont, Florida, 34711, United States

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89bio Clinical Study Site

Fort Myers, Florida, 33912, United States

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89bio Clinical Study Site

Gainesville, Florida, 32610, United States

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89bio Clinical Study Site

Hialeah Gardens, Florida, 33016, United States

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89bio Clinical Study Site

Homestead, Florida, 33030, United States

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89bio Clinical Study Site

Jacksonville, Florida, 32224, United States

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89bio Clinical Study Site

Jacksonville, Florida, 32256, United States

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89bio Clinical Study Site

Lady Lake, Florida, 32159, United States

WITHDRAWN

89bio Clinical Study Site

Lakewood Rch, Florida, 34211, United States

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89bio Clinical Study Site

Lehigh Acres, Florida, 33936, United States

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89bio Clinical Study Site

Maitland, Florida, 32751, United States

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89bio Clinical Study Site

Miami, Florida, 33144, United States

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89bio Clinical Study Site

Miami, Florida, 33176-1530, United States

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89bio Clinical Study Site

Miami, Florida, 33176-7947, United States

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89bio Clinical Study Site

New Port Richey, Florida, 34653, United States

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89bio Clinical Study Site

Ocala, Florida, 34471, United States

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89bio Clinical Study Site

Ocoee, Florida, 34761, United States

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89bio Clinical Study Site

Orlando, Florida, 32825, United States

WITHDRAWN

89bio Clinical Study Site

University Park, Florida, 34201, United States

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89bio Clinical Study Site

Viera, Florida, 32940, United States

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89bio Clinical Study Site

Winter Park, Florida, 32789, United States

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89bio Clinical Study Site

Athens, Georgia, 30607, United States

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89bio Clinical Study Site

Atlanta, Georgia, 30309, United States

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89bio Clinical Study Site

Chicago, Illinois, 60611, United States

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89bio Clinical Study Site

Hammond, Indiana, 46324, United States

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89bio Clinical Study Site

New Albany, Indiana, 47150, United States

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89bio Clinical Study Site

South Bend, Indiana, 46635, United States

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89bio Clinical Study Site

Iowa City, Iowa, 52242, United States

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89bio Clinical Study Site

Kansas City, Kansas, 66160, United States

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89bio Clinical Study Site

Topeka, Kansas, 66606, United States

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89bio Clinical Study Site

Lafayette, Louisiana, 70503, United States

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89bio Clinical Study Site

Lake Charles, Louisiana, 70605, United States

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89bio Clinical Study Site

West Monroe, Louisiana, 71291, United States

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89bio Clinical Study Site

Baltimore, Maryland, 21202, United States

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89bio Clinical Study Site

Glen Burnie, Maryland, 21061, United States

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89bio Clinical Study Site

Greenbelt, Maryland, 20770, United States

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89bio Clinical Study Site

Burlington, Massachusetts, 01805, United States

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89bio Clinical Study Site

Ann Arbor, Michigan, 48109, United States

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89bio Clinical Study Site

Clinton Township, Michigan, 48038, United States

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89bio Clinical Study Site

Detroit, Michigan, 48202, United States

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89bio Clinical Study Site

Wyoming, Michigan, 49519, United States

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89bio Clinical Study Site

Ypsilanti, Michigan, 48197, United States

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89bio Clinical Study Site

Minneapolis, Minnesota, 55413, United States

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89bio Clinical Study Site

Rochester, Minnesota, 55905, United States

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89bio Clinical Study Site

Flowood, Mississippi, 39232, United States

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89bio Clinical Study Site

Tupelo, Mississippi, 38801, United States

WITHDRAWN

89bio Clinical Study Site

St Louis, Missouri, 63110, United States

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89bio Clinical Study Site

St Louis, Missouri, 63123, United States

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89bio Clinical Study Site

Las Vegas, Nevada, 89106, United States

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89bio Clinical Study Site

Florham Park, New Jersey, 07932, United States

WITHDRAWN

89bio Clinical Study Site

Somers Point, New Jersey, 08244, United States

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89bio Clinical Study Site

Albuquerque, New Mexico, 87109, United States

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89bio Clinical Study Site

New York, New York, 10016, United States

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89bio Clinical Study Site

New York, New York, 10021, United States

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89bio Clinical Study Site

New York, New York, 10033, United States

WITHDRAWN

89bio Clinical Study Site

Asheville, North Carolina, 28801, United States

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89bio Clinical Study Site

Charlotte, North Carolina, 28207, United States

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89bio Clinical Study Site

Durham, North Carolina, 27710, United States

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89bio Clinical Study Site

Fayetteville, North Carolina, 28304, United States

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89bio Clinical Study Site

Greenville, North Carolina, 27834, United States

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89bio Clinical Study Site

Winston-Salem, North Carolina, 27103, United States

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89bio Clinical Study Site

Akron, Ohio, 44320, United States

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89bio Clinical Study Site

Cincinnati, Ohio, 45267, United States

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89bio Clinical Study Site

Cleveland, Ohio, 44106, United States

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89bio Clinical Study Site

Columbus, Ohio, 43210, United States

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89bio Clinical Study Site

Dayton, Ohio, 45414, United States

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89bio Clinical Study Site

Liberty Township, Ohio, 45044, United States

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89bio Clinical Study Site

Westlake, Ohio, 44145, United States

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89bio Clinical Study Site

Philadelphia, Pennsylvania, 19148, United States

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89bio Clinical Study Site

Pittsburgh, Pennsylvania, 15213, United States

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89bio Clinical Study Site

East Greenwich, Rhode Island, 02818, United States

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89bio Clinical Study Site

Charleston, South Carolina, 29425, United States

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89bio Clinical Study Site

Columbia, South Carolina, 29204, United States

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89bio Clinical Study Site

Rapid City, South Dakota, 57701, United States

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89bio Clinical Study Site

Cordova, Tennessee, 38018, United States

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89bio Clinical Study Site

Hermitage, Tennessee, 37076, United States

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89bio Clinical Study Site

Nashville, Tennessee, 37211, United States

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89bio Clinical Study Site

Amarillo, Texas, 79106, United States

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89bio Clinical Study Site

Austin, Texas, 78745, United States

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89bio Clinical Study Site

Austin, Texas, 78757-8059, United States

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89bio Clinical Study Site

Austin, Texas, 78757-8066, United States

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89bio Clinical Study Site

Brownsville, Texas, 78520, United States

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89bio Clinical Study Site

DeSoto, Texas, 75115, United States

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89bio Clinical Study Site

Edinburg, Texas, 78539, United States

WITHDRAWN

89bio Clinical Study Site

Farmers Branch, Texas, 75234, United States

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89bio Clinical Study Site

Fort Worth, Texas, 76104, United States

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89bio Clinical Study Site

Harlingen, Texas, 78550, United States

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89bio Clinical Study Site

Houston, Texas, 77030, United States

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89bio Clinical Study Site

Houston, Texas, 77074, United States

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89bio Clinical Study Site

Houston, Texas, 77099, United States

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89bio Clinical Study Site

Lewisville, Texas, 75067, United States

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89bio Clinical Study Site

Lubbock, Texas, 79410, United States

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89bio Clinical Study Site

Mansfield, Texas, 76063, United States

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89bio Clinical Study Site

Pearland, Texas, 77584, United States

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89bio Clinical Study Site

San Antonio, Texas, 78209, United States

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89bio Clinical Study Site

San Antonio, Texas, 78229-4801, United States

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89bio Clinical Study Site

San Antonio, Texas, 78229-5069, United States

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89bio Clinical Study Site

San Marcos, Texas, 78666, United States

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89bio Clinical Study Site

Waco, Texas, 76710, United States

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89bio Clinical Study Site

Waco, Texas, 76712, United States

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89bio Clinical Study Site

Sandy City, Utah, 84092, United States

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89bio Clinical Study Site

West Jordan, Utah, 84088, United States

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89bio Clinical Study Site

Richmond, Virginia, 23226, United States

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89bio Clinical Study Site

Richmond, Virginia, 23229, United States

WITHDRAWN

89bio Clinical Study Site

Richmond, Virginia, 23236, United States

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89bio Clinical Study Site

Richmond, Virginia, 23298, United States

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89bio Clinical Study Site

Seattle, Washington, 98101, United States

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89bio Clinical Study Site

Seattle, Washington, 98105, United States

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89bio Clinical Study Site

Buenos Aires, C1012AAR, Argentina

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89bio Clinical Study Site

Buenos Aires, C1125ABE, Argentina

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89bio Clinical Study Site

Buenos Aires, C1199ABB, Argentina

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89bio Clinical Study Site

Buenos Aires, C1425BGH, Argentina

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89bio Clinical Study Site

Buenos Aires, CP 1061, Argentina

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89bio Clinical Study Site

CABA, C1430CKE, Argentina

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89bio Clinical Study Site

Capital Federal, C1280AEB, Argentina

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89bio Clinical Study Site

Pilar, B1629AHJ, Argentina

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89bio Clinical Study Site

Adelaide, SA 5000, Australia

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89bio Clinical Study Site

Fitzroy, 03065, Australia

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89bio Clinical Study Site

Greenslopes, 04120, Australia

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89bio Clinical Study Site

Heidelberg, 3084, Australia

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89bio Clinical Study Site

Herston, Qld 4029, Australia

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89bio Clinical Study Site

Murdoch, 06150, Australia

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89bio Clinical Study Site

Perth, 06000, Australia

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89bio Clinical Study Site

South Brisbane, 04101, Australia

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89bio Clinical Study Site

Brussels, 01070, Belgium

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89bio Clinical Study Site

Brussels, 01090, Belgium

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89bio Clinical Study Site

Brussels, 1200, Belgium

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89bio Clinical Study Site

Edegem, 02650, Belgium

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89bio Clinical Study Site

Genk, 03600, Belgium

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89bio Clinical Study Site

Ghent, 09000, Belgium

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89bio Clinical Study Site

Roeselare, 08800, Belgium

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89bio Clinical Study Site

Barretos, 14784-400, Brazil

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89bio Clinical Study Site

Belo Horizonte, 30220-140, Brazil

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89bio Clinical Study Site

Botucatu, 18618-687, Brazil

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89bio Clinical Study Site

Goiânia, 74605-050, Brazil

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89bio Clinical Study Site

Porto Alegre, 90035-903, Brazil

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89bio Clinical Study Site

Rio de Janeiro, 21941-617, Brazil

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89bio Clinical Study Site

Salvador, 41820-460, Brazil

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89bio Clinical Study Site

São José do Rio Preto, 15090-000, Brazil

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89bio Clinical Study Site

São Paulo, 04038-002, Brazil

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89bio Clinical Study Site

Gorna Oryahovitsa, 05100, Bulgaria

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89bio Clinical Study Site

Sofia, 01202, Bulgaria

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89bio Clinical Study Site

Sofia, 01407, Bulgaria

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89bio Clinical Study Site

Stara Zagora, 06003, Bulgaria

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89bio Clinical Study Site

Calgary, Alberta, T2N 4Z6, Canada

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89bio Clinical Study Site

Vancouver, British Columbia, V5Z 1M9, Canada

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89bio Clinical Study Site

Vancouver, British Columbia, V6Z2K5, Canada

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89bio Clinical Study Site

Winnipeg, Manitoba, R3E 3P4, Canada

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89bio Clinical Study Site

London, Ontario, N6A5A5, Canada

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89bio Clinical Study Site

Ottawa, Ontario, K1H 8L6, Canada

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89bio Clinical Study Site

Toronto, Ontario, M6H3M1, Canada

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89bio Clinical Study Site

Vaughan, L4L 4Y7, Canada

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89bio Clinical Study Site

Amiens, 80054, France

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89bio Clinical Study Site

Dijon, 21000, France

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89bio Clinical Study Site

Limoges, 87000, France

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89bio Clinical Study Site

Lyon, 69004, France

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89bio Clinical Study Site

Montpellier, 34295, France

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89bio Clinical Study Site

Nice, 06202, France

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89bio Clinical Study Site

Paris, 75012, France

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89bio Clinical Study Site

Paris, 75013, France

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89bio Clinical Study Site

Paris, 75014, France

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89bio Clinical Study Site

Pessac, 33604, France

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89bio Clinical Study Site

Strasbourg, 67091, France

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89bio Clinical Study Site

Toulouse, 31400, France

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89bio Clinical Study Site

Vandœuvre-lès-Nancy, 54500, France

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89bio Clinical Study Site

Vénissieux, 69694, France

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89bio Clinical Study Site

Villejuif, 94800, France

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89bio Clinical Study Site

Chemnitz, 9116, Germany

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89bio Clinical Study Site

Frankfurt, 60590, Germany

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89bio Clinical Study Site

Freiburg im Breisgau, 79110, Germany

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89bio Clinical Study Site

Hanover, 30625, Germany

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89bio Clinical Study Site

Homburg, 66421, Germany

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89bio Clinical Study Site

Münster, 48149, Germany

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89bio Clinical Study Site

Hong Kong, Hong Kong

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89bio Clinical Study Site

Shatin, Hong Kong

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89bio Clinical Study Site

Budapest, 01027, Hungary

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89bio Clinical Study Site

Budapest, 01088, Hungary

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89bio Clinical Study Site

Budapest, H-1097, Hungary

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89bio Clinical Study Site

Afula, 1834111, Israel

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89bio Clinical Study Site

Beersheba, 8410101, Israel

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89bio Clinical Study Site

Haifa, 3109601, Israel

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89bio Clinical Study Site

Haifa, 3436212, Israel

ENROLLING BY INVITATION

89bio Clinical Study Site

Jerusalem, 9112001, Israel

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89bio Clinical Study Site

Nahariya, 2210001, Israel

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89bio Clinical Study Site

Petah Tikva, 49100, Israel

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89bio Clinical Study Site

Tel Aviv, 69710, Israel

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89bio Clinical Study Site

Tel Litwinsky, 5265601, Israel

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89bio Clinical Study Site

Bergamo, 24127, Italy

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89bio Clinical Study Site

Foggia, 71121, Italy

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89bio Clinical Study Site

Milan, 20122, Italy

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89bio Clinical Study Site

Milan, 20162, Italy

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89bio Clinical Study Site

Novara, 28100, Italy

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89bio Clinical Study Site

Palermo, 90127, Italy

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89bio Clinical Study Site

Roma, 00128, Italy

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89bio Clinical Study Site

Rome, 00168, Italy

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89bio Clinical Study Site

Rozzano, 20089, Italy

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89bio Clinical Study Site

Torino, 10124, Italy

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89bio Clinical Study Site

Chihuahua City, 31217, Mexico

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89bio Clinical Study Site

Cuautitlán Izcalli, CP 54769, Mexico

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89bio Clinical Study Site

Cuernavaca, 62250, Mexico

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89bio Clinical Study Site

Jalisco, 44130, Mexico

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89bio Clinical Study Site

Mexico City, 03330, Mexico

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89bio Clinical Study Site

Mexico City, 06700, Mexico

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89bio Clinical Study Site

Mérida, 97070, Mexico

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89bio Clinical Study Site

Monterrey, 64310, Mexico

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89bio Clinical Study Site

Amsterdam, 1081 HV, Netherlands

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89bio Clinical Study Site

Rotterdam, 3015GD, Netherlands

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89bio Clinical Study Site

Tilburg, 5022 GC, Netherlands

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89bio Clinical Study Site

Utrecht, 3584 CX, Netherlands

WITHDRAWN

89bio Clinical Study Site

Katowice, 40-752, Poland

WITHDRAWN

89bio Clinical Study Site

Krakow, 31-501, Poland

RECRUITING

89bio Clinical Study Site

Lodz, 90-302, Poland

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89bio Clinical Study Site

Lodz, 91-363, Poland

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89bio Clinical Study Site

Mysłowice, 41-400, Poland

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89bio Clinical Study Site

Warsaw, 00-215, Poland

WITHDRAWN

89bio Clinical Study Site

Warsaw, 04-501, Poland

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89bio Clinical Study Site

Wroclaw, 53-673, Poland

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89bio Clinical Study Site

Mayagüez, 00680, Puerto Rico

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89bio Clinical Study Site

San Juan, 00927, Puerto Rico

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89bio Clinical Study Site

Singapore, 119074, Singapore

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89bio Clinical Study Site

Singapore, 169608, Singapore

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89bio Clinical Study Site

Singapore, 308433, Singapore

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89bio Clinical Study Site

Singapore, 529889, Singapore

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89bio Clinical Study Site

Bucheon-si, 14584, South Korea

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89bio Clinical Study Site

Busan, 49241, South Korea

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89bio Clinical Study Site

Daegu, 42415, South Korea

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89bio Clinical Study Site

Daegu, 700-712, South Korea

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89bio Clinical Study Site

Seoul, 03080, South Korea

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89bio Clinical Study Site

Seoul, 06591, South Korea

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89bio Clinical Study Site

Seoul, 07061, South Korea

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89bio Clinical Study Site

Seoul, 07895, South Korea

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89bio Clinical Study Site

Seoul, 130-872, South Korea

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89bio Clinical Study Site

Almería, 04009, Spain

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89bio Clinical Study Site

Badalona, 08916, Spain

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89bio Clinical Study Site

Barcelona, 08003, Spain

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89bio Clinical Study Site

Barcelona, 08035, Spain

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89bio Clinical Study Site

Barcelona, 08041, Spain

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89bio Clinical Study Site

Córdoba, 14004, Spain

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89bio Clinical Study Site

Madrid, 28007, Spain

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89bio Clinical Study Site

Málaga, 29010, Spain

WITHDRAWN

89bio Clinical Study Site

Pontevedra, 36071, Spain

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89bio Clinical Study Site

Santander, 39008, Spain

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89bio Clinical Study Site

Santiago de Compostela, 15706, Spain

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89bio Clinical Study Site

Zaragoza, 50009, Spain

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89bio Clinical Study Site

Chiayi City, 60002, Taiwan

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89bio Clinical Study Site

Kaohsiung City, 80756, Taiwan

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89bio Clinical Study Site

Tainan, 00704, Taiwan

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89bio Clinical Study Site

Bornova, İzmir, 35040, Turkey (Türkiye)

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89bio Clinical Study Site

Merkez, Rize Province, 53020, Turkey (Türkiye)

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89bio Clinical Study Site

Ankara, 06100, Turkey (Türkiye)

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89bio Clinical Study Site

Ankara, 6800, Turkey (Türkiye)

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89bio Clinical Study Site

Fatih, 34093, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Istanbul, 34010, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Istanbul, 34722, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Izmir, 35360, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Umraniye, 34764, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Yüreğir, 1370, Turkey (Türkiye)

RECRUITING

89bio Clinical Study Site

Aberdeen, AB25 2ZN, United Kingdom

RECRUITING

89bio Clinical Study Site

Bristol, BS10 5NB, United Kingdom

RECRUITING

89bio Clinical Study Site

Leeds, LS9 7TF, United Kingdom

RECRUITING

89bio Clinical Study Site

London, E1 1BB, United Kingdom

RECRUITING

89bio Clinical Study Site

London, NW3 2QG, United Kingdom

RECRUITING

89bio Clinical Study Site

London, SE5 9RS, United Kingdom

RECRUITING

89bio Clinical Study Site

London, W2 1NY, United Kingdom

RECRUITING

89bio Clinical Study Site

Oxford, OX3 9DU, United Kingdom

RECRUITING

89bio Clinical Study Site

Plymouth, PL6 8DH, United Kingdom

RECRUITING

89bio Clinical Study Site

Port Talbot, SA12 7BR, United Kingdom

RECRUITING

89bio Clinical Study Site

Portsmouth, P06 3LY, United Kingdom

RECRUITING

89bio Clinical Study Site

Southampton, SO16 6YD, United Kingdom

RECRUITING

MeSH Terms

Conditions

Non-alcoholic Fatty Liver DiseaseLiver DiseasesFatty LiverDigestive System DiseasesMetabolic DiseasesFibrosis

Condition Hierarchy (Ancestors)

Nutritional and Metabolic DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Maya Margalit, MD

    89bio, Inc.

    STUDY DIRECTOR

Central Study Contacts

ENLIGHTEN clinical trial

CONTACT

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 14, 2024

First Posted

May 17, 2024

Study Start

May 24, 2024

Primary Completion (Estimated)

June 1, 2028

Study Completion (Estimated)

August 1, 2031

Last Updated

May 6, 2026

Record last verified: 2026-05

Locations