InformationSeekingMesolimbicEngagementStudy1

NCT06257446 | Completed Results

• 2 other identifiers: R01DA055259-1R01DA055259-03
• Study Type: interventional
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

Study 1 will use a novel Game Show task, in which the investigators manipulate participant's agency to control their learning environment to specify unguided exploration.

Conditions

Motivation

Outcome Measures

Primary Outcomes (2)

• Mesolimbic-hippocampal Interactions

  Functional Magnetic Resonance Imaging Activation characterizing mesolimbic-hippocampal interactions as queried using representational simliarity analysis across these two regions of interest. In this analysis, we explore the pattern similarity within the same set of regions (mesolimbic and hippocampal regions) across different trial types. In this way the standard unit for these values reflect a correlation that is summarized by a standardized beta-value extracted from a nested mixed effects model.

  During Procedure

• Episodic Memory

  Item and Associative memory for memoranda shown during the task. This measure reflects the percent of memory test retrieval trials in which participants were able to successfull remember an item and its associated features compared across a high and low reward condition.

  24-hours, we administered our memory test 24 hours after the first session but this is the first time we are administering this test.

Study Arms (1)

Motivation

EXPERIMENTAL

Trials in which participants are motivated by agency or not in a within-subjects design

Behavioral: Task Instructions

Interventions

Task Instructions BEHAVIORAL

Participants will be given cued instructions as to whether they are in a high or low motivation condition

Motivation

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• /40 far acuity (either corrected or uncorrected)
• In good medical health

You may not qualify if:

• History of head injury
• History of illness with Central Nervous Systems implications
• On Medications that Affect blood flow response and alertness
• Consumption of smoking and/or coffee 30 minutes prior to laboratory testing
• Placement of a device contraindicated for magnetic resonance imaging including cardia pacemaker, aneurysm clip, cochlear implants, pregnancy, intra-uterine device, shrapnel, metal fragments in the eyes, neurostimulators
• Weight \> 250lbs
• Claustrophobia

Sponsors & Collaborators

• Temple University: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

Temple University

Philadelphia, Pennsylvania, 19122, United States

Location

Results Point of Contact

• Title: Vishnu Murty
• Organization: University of Oregon

murty@uoregon.edu

740-6328932

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 31, 2024
• First Posted: February 14, 2024
• Study Start: October 25, 2023
• Primary Completion: February 9, 2024
• Study Completion: February 9, 2024
• Last Updated: April 23, 2026
• Results First Posted: April 23, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ANALYTIC CODE
• Time Frame: Data will be shared within 1 year of study completion, and it will be available for at least 10 years.

Locations

US (1)