NCT06257433

Brief Summary

Participants will complete a treasure task during neuroimaging where they have to learn which keys open a treasure chest, and then they are tested on the contents of the treasure chest.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
3mo left

Started Oct 2023

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress92%
Oct 2023Aug 2026

Study Start

First participant enrolled

October 24, 2023

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

January 31, 2024

Completed
14 days until next milestone

First Posted

Study publicly available on registry

February 14, 2024

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2026

Last Updated

September 5, 2025

Status Verified

August 1, 2025

Enrollment Period

2.8 years

First QC Date

January 31, 2024

Last Update Submit

August 28, 2025

Conditions

Motivation

Outcome Measures

Primary Outcomes (2)

  • Mesolimbic Hippocampal Interactions

    Functional Magnetic Resonance Imaging Activation characterizing Mesolimbic-Hippocampal Interactions

    During Procedure

  • Episodic Memory

    Item and Associative Memory for memoranda shown during the task

    24-hours After Procedure

Study Arms (1)

Motivation

EXPERIMENTAL

Trials in which participants are motivated by hypothesis testing or not.

Behavioral: Task Instructions

Interventions

Task InstructionsBEHAVIORAL

Participants will be given cued instructions as to whether they are in a high or low motivation condition

Motivation

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • /40 far acuity (either corrected or uncorrected)
  • In good medical health

You may not qualify if:

  • History of head injury
  • History of illness with Central Nervous Systems implications
  • On Medications that Affect blood flow response and alertness
  • Consumption of smoking and/or coffee 30 minutes prior to laboratory testing
  • Placement of a device contraindicated for magnetic resonance imaging including cardia pacemaker, aneurysm clip, cochlear implants, pregnancy, intra-uterine device, shrapnel, metal fragments in the eyes, neurostimulators
  • Weight \> 250lbs
  • Claustrophobia

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Temple University

Philadelphia, Pennsylvania, 19122, United States

RECRUITING

Central Study Contacts

Vishnu Murty, PhD

CONTACT

7406328932vishnu.murty@temple.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 31, 2024

First Posted

February 14, 2024

Study Start

October 24, 2023

Primary Completion (Estimated)

August 1, 2026

Study Completion (Estimated)

August 1, 2026

Last Updated

September 5, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will share

Deidentified data will be shared on the open science framework.

Shared Documents
ANALYTIC CODE
Time Frame
Data will be shared within 1 year of study completion, and it will be available for at least 10 years.

Locations

US(1)