NCT07159308

Brief Summary

The goal of this clinical trial is to enhance motivation to complete daily living skills among 16 to 25-year-old autistic teens and young adults. Here are the main questions the trial aims to answer: Can this trial improve motivation to complete daily living skills for skills that people know how to do but struggle to do them consistently? Can this trial improve completion of the daily living skill that the participant identifies they want to do more often? Do people report feeling more empowered to complete the daily living skill they want to do more often? Are there any characteristics of a person that make them more or less likely to benefit from the treatment? Researchers will compare treatments that target different types of motivation:

  • One treatment focuses on internal motivation and explores what is important to someone and then connect that value back to their daily living skill goal.
  • A second treatment focuses on external motivation and will explore a person finding outside sources of motivation, like rewards.
  • A third treatment will use a combination of both methods. Autistic teens and young adults enrolled in this study will also be asked to choose someone in their life to be involved in the study with them. This person is called an "Important Person" (IP) and can be anyone close to them, like a family member, friend, roommate, partner, etc. The IP will be expected to support the teen/young adult throughout this treatment. Participants and their IPs will:
  • Complete five 'talk' therapy sessions that will last 60 to 90 minutes. The IPs will join the last 15 minutes of each session)
  • Be assigned to one of the three motivation treatments
  • Fill out questionnaires before the first session, after sessions 2 through 5, and 2 weeks after therapy ends

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
180

participants targeted

Target at P75+ for not_applicable

Timeline
9mo left

Started Sep 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress47%
Sep 2025Feb 2027

First Submitted

Initial submission to the registry

August 29, 2025

Completed
10 days until next milestone

First Posted

Study publicly available on registry

September 8, 2025

Completed
7 days until next milestone

Study Start

First participant enrolled

September 15, 2025

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2027

Last Updated

October 2, 2025

Status Verified

October 1, 2025

Enrollment Period

1.4 years

First QC Date

August 29, 2025

Last Update Submit

October 1, 2025

Conditions

Keywords

InterventionsMotivationAutism Spectrum DisorderDaily Living SkillsTransition to Adulthoodbehavior therapymotivational interviewing

Outcome Measures

Primary Outcomes (1)

  • Motivation to Change

    The primary outcome measure for this study is the individual's motivation to change and improve upon their daily living skill. Motivation will be measured through 4 separate questions that ask about one's desire, ability, need, and commitment to change. All 4 questions will use the same scale, which ranges from 1 - 10. A total score will be used as the measure. This total score will be calculated by adding the score from each individual question. A higher score indicates a greater level of motivation.

    Up to 9 weeks.

Secondary Outcomes (2)

  • Behavior Change Scale

    Up to 9 weeks.

  • Empowerment Measure

    Up to 9 weeks.

Study Arms (3)

Intrinsic Motivation Treatment

EXPERIMENTAL

Individuals assigned to this group will participate in the Intrinsic Motivation Treatment, which focuses on exploring a person's reasons for improving their completion of the daily living skill, such as reaching their goal of independence.

Behavioral: Intrinsic Motivation Treatment

Extrinsic Motivation Treatment

ACTIVE COMPARATOR

Individuals assigned to this group will participate in the Extrinsic Motivation Treatment. This treatment explores a person finding outside sources of motivation, such as treating themselves to something like or want.

Behavioral: Extrinsic Motivation Treatment

Combined Intrinsic and Extrinsic Motivation Treatment

EXPERIMENTAL

Individuals assigned to this group will participate in the Combined Intrinsic and Extrinsic Motivation Treatment. This treatment combines methods from the Intrinsic Motivation Treatment and the Extrinsic Motivation Treatment. For example, exploring both a person's reasons behind wanting to improve upon their completion of a daily living skill as well as what outside sources will help increase their motivation to improve upon that skill.

Behavioral: Combined Intrinsic and Extrinsic Motivation Treatment

Interventions

The Intrinsic Motivation treatment utilizes principles of Motivational Interviewing to help autistic young adults increase their desire and completion of daily living skills. This is a five-session intervention. Each clinical session is 60 minutes long. The goals of the treatment are to enhance motivation and behavior change.

Intrinsic Motivation Treatment

The Extrinsic Motivation treatment utilizes behavioral principles to help autistic adolescents and young adults create reward schedules and behavioral tracking sheets to enhance desire and completion of daily living skills. This is a five-session intervention. Each clinical session is 60 minutes long. The goals of the treatment are to enhance motivation and behavior change.

Extrinsic Motivation Treatment

The Combined Intrinsic and Extrinsic Motivation treatment combines elements of both intrinsic and extrinsic motivation treatments to enhance desire and completion of daily living skills. This is a five-session intervention. Each clinical session is 60-90 minutes long. The goals of the treatment are to enhance motivation and behavior change.

Combined Intrinsic and Extrinsic Motivation Treatment

Eligibility Criteria

Age16 Years - 25 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Age 16-25 years
  • Participants reporting an autism diagnosis from a qualified provider (Psychiatrist, Psychologist, Developmental Pediatrician, Neurologist). When possible, diagnosis will be confirmed through the Children's Hospital of Philadelphia (CHOP) Electronic Health Record (EHR).
  • Must identify an important person who is able to communicate by understanding and speaking full sentences in English
  • Ability to communicate by understanding and using full sentences in English
  • Informed Consent
  • Be willing to have sessions audio- and video-recorded

You may not qualify if:

  • Diagnosis of Intellectual Disability
  • Participant is currently considered a suicide risk in the opinion of the Investigator or is currently demonstrating active suicidal or homicidal ideation or self-injurious behavior.
  • Current, comorbid psychiatric disorder with sufficiently intense symptoms in the opinion of the Investigator that these symptoms may confound treatment.
  • Changes to mental health treatment plan (ex. starting or ending therapy or psychotropic medications over the course of this intervention).
  • Participation in a prior trial of our intrinsic motivation condition
  • Age 18 years or older
  • Must attend at least 15 minutes of each treatment session
  • Ability to communicate by understanding and using full sentences in English
  • Informed consent
  • Be willing to have sessions audio- and video-recorded
  • \- Is not willing to support the autistic teen/young adult with their daily living skill goal

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHOP Center for Advanced Behavioral Healthcare

Philadelphia, Pennsylvania, 19139, United States

RECRUITING

MeSH Terms

Conditions

Autism Spectrum Disorder

Condition Hierarchy (Ancestors)

Child Development Disorders, PervasiveNeurodevelopmental DisordersMental Disorders

Study Officials

  • Benjamin E Yerys, PhD

    Children's Hospital of Philadelphia

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Benjamin E Yerys, PhD

CONTACT

Madi Leach, Bachelors of Science

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 29, 2025

First Posted

September 8, 2025

Study Start

September 15, 2025

Primary Completion (Estimated)

February 1, 2027

Study Completion (Estimated)

February 1, 2027

Last Updated

October 2, 2025

Record last verified: 2025-10

Locations