Effect of Two Years of Resistance Training in Cardiac Function in Older Women: a Randomized Controlled Trial

NCT06160141 | Completed DMC

• 1 other identifier: GEPEMENE 2023
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

Purpose: This study aimed to determine the effect of 48 weeks of resistance training (RT) on cardiac function in older women. Methods: Sixty-four older women (≥ 60 years), physically independent, were selected for this study. Participants were randomized into a training group (TG, n = 33) and a control group (CG, n = 31). The RT program was conducted over 48 weeks, three sessions a week, on nonconsecutive days, in the morning hours. Participants performed eight exercises for the whole body (chest press, horizontal leg press, seated row, leg extension, triceps pushdown, lying leg curl, preacher curl, seated calf raise) in three sets of 8-12 repetitions. The echocardiography was performed according to current guidelines before and after 48 weeks by an experienced echocardiographer blinded to patient status and group assignment. One-repetition maximum (1-RM) tests were used to analyze muscular strength. Glusoce, lipid profile, and C-reactive protein were measured. DEXA was used to measure body fat and muscle mass.

Conditions

Aging; Healthy

Outcome Measures

Primary Outcomes (1)

• Doppler-echocardiography

  Echocardiography exams were performed according to current guidelines, at baseline and the end of the study, by an experienced echocardiographer blinded to patient status and group. According to current recommendations, cardiac chamber dimensions, volumes, and left ventricular mass were measured. Mitral inflow velocities were assessed using pulsed-wave Doppler in the apical four-chamber view, with the sample volume placed between the tips of the mitral leaflets; velocities were recorded at end-expiration. Tissue Doppler velocities were acquired at end-expiration, in the apical four-chamber view, with the sample positioned at the septal and lateral mitral annulus for determination of systolic (S'), early diastolic (E'), and late diastolic (A') velocities. Pulsed wave Doppler velocities at the upper right pulmonary vein were also recorded. For all parameters, the average of three consecutive heartbeats was recorded.

  48 weeks

Secondary Outcomes (13)

• Dietary intake

  48 weeks

• Muscular strength

  48 weeks

• Body composition

  48 weeks

• Gait speed test

  48 weeks

• walking agility test

  48 weeks

Study Arms (2)

Training group

EXPERIMENTAL

The training group performed 48 weeks of resistance training, 3 times per week.

Other: Resistance training

Control Group

NO INTERVENTION

The control group did not performed any kind of resistance exercises.

Interventions

Resistance training OTHER

Resistance training program. The RT program was performed over 48 weeks, three times per week (Mondays, Wednesdays, and Fridays), during the morning, in the University fitness facility. Participants were personally supervised by Physical Education professionals (1-2 supervisors per exercise) with substantial RT experience to ensure consistent and safe exercise performance. Participants performed four exercises for the trunk and upper limbs and four exercises for the lower limbs in three sets of 8-12 repetitions. T Rest intervals were 1-2 and 2-3 min between sets and exercises. The training load was individually adjusted for each exercise weekly, according to the number of repetitions performed during the last training session, to ensure that the subjects kept performing at the ideal intensity for the repetition zone. In these situations, training loads were increased by 2-5% for upper-limb exercises and 5-10% for lower-limb exercises.

Training group

Eligibility Criteria

• Age: 60 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• females aged ≥ 60 years; physically independent; had no cardiac, orthopedic, or musculoskeletal dysfunction that could impede physical exercise; not having uncontrolled diabetes mellitus or hypertension; and not be involved in the practice of regular physical activity performed more than once a week over the three months before the start of the study

You may not qualify if:

• Not completed at least 80% of the sessions.

Sponsors & Collaborators

• Universidade Estadual de Londrina: lead

Study Sites (1)

Universidade Estadual de Londrina

Londrina, Paraná, 86.057-970, Brazil

Location

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Assessor was blind to the primary outcome
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Model Details: Training groups vs. Control Group

Study Record Dates

• First Submitted: November 9, 2023
• First Posted: December 7, 2023
• Study Start: March 1, 2018
• Primary Completion: December 20, 2019
• Study Completion: December 20, 2019
• Last Updated: December 7, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)