Physical Activity and Exercise in Cancer Immunotherapy Treatment

NCT06152926 | Unknown DMC

• 1 other identifier: 15438
• Study Type: observational
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

People who are diagnosed with a cancer commonly experience symptoms that affect day-to-day life, including muscle weakness, pain, tiredness and fatigue. These consequences can make it hard for people to tolerate their medical treatments. It is well known that regular physical activity or planned exercise can help with these symptoms and significantly improve physical and mental health during cancer treatment. Recent animal studies suggest that exercise training can also reduce the number of cancer cells. For example, exercise training in mice produces more immune cells in the tumour. These immune cells in the tumour contribute to the destruction and reduction of the size of the tumour and are a vital component of effective immunotherapy (cancer treatment that helps your immune system fight cancer). In humans, exercise training and the effect on the immune response in tumours are less understood and is a new area being explored. However, we are aware that most people diagnosed with a cancer are not physically active, and especially not during the treatment period. The aim of this study is to understand the experiences and perceptions of physical activity and exercise in those with cancer receiving immunotherapy treatment (such as immune check point inhibitors (ICI). This will help us to create new practices or change practices to help those with cancer to partake in physical activity and exercise when on treatment. Participants consenting to take part in the study will be individually interviewed through a semi-structured interview.

Conditions

Cancer

Outcome Measures

Primary Outcomes (1)

• Exploration of experiences

  To understand participant's perspectives and experiences of physical activity and exercise on immune check point immunotherapy treatment through Inductive thematic analysis of semi-structured individual interviews.

  3-6 months

Interventions

Physical Activity and Exercise in Cancer Immunotherapy Treatment - Exploratory study of experiences and perceptions OTHER

People diagnosed with a urological cancer receiving Immune checkpoint inhibitor treatment at a single centre trust will be invited to either face to face or online video-conference individual interviews (Microsoft teams) according to participant preference. Consenting participants will be interviewed via semi-structured interview methods round a topic guide and audio-recorded. Inductive thematic analysis will be conducted to explore participant experiences and perceptions of physical activity and exercise.

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

People with a urological cancer (Bladder or Renal) that are receiving or planned to receive immunotherapy treatment (with immune check point inhibitors) at a single centre.

You may qualify if:

• Primary Urological (Bladder and Renal) cancer diagnosis receiving or planned immune check point inhibitor treatment at GSTT hospital.
• Adults aged 18 years or older
• Willing and able to take part in Face to Face interviews at a hospital site or virtual video interviews at home.
• Cancer survival \>6 month
• Proficient in English

You may not qualify if:

• Aged lower than 18 years
• Inability to give informed consent and information (due to unable to speak or understand English)

Sponsors & Collaborators

• Guy's and St Thomas' NHS Foundation Trust: lead

Related Publications (1)

• Handford J, Chen M, Rai R, Moss CL, Enting D, Peat N, Karagiannis SN, Van Hemelrijck M, Russell B. Is There a Role for Exercise When Treating Patients with Cancer with Immune Checkpoint Inhibitors? A Scoping Review. Cancers (Basel). 2022 Oct 14;14(20):5039. doi: 10.3390/cancers14205039.

  PMID: 36291823 RESULT

MeSH Terms

Conditions

Neoplasms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Mieke Van-Helmerijk

  King's College London

  STUDY CHAIR

Central Study Contacts

Nicola M Peat

CONTACT

+442071889654; nicola.peat@gstt.nhs.uk

Gareth D Jones

CONTACT

+442071889654; Gareth.Jones@gstt.nhs.uk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant Physiotherapist

Study Record Dates

• First Submitted: November 22, 2023
• First Posted: December 1, 2023
• Study Start: December 4, 2023
• Primary Completion: January 31, 2024
• Study Completion: June 30, 2024
• Last Updated: December 1, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share