The CASCADE Project

NCT06117592 | Not Yet Recruiting

• 1 other identifier: cftsp227
• Study Type: observational
• Target: 1,400
• Locations: 0 countries
• Sites: N/A

Brief Summary

People with cancer, treated for cancer, or have been recently treated for cancer are at a higher risk of becoming rapidly unwell. This is referred to as an oncological emergency and can be life-threatening. The investigators want to see if a new, standardised assessment of acute oncology knowledge and skills of all health care staff (The Acute Oncology Passport) following education and training, has an effect on the diagnosis and treatment of two relatively-common oncological emergencies: sepsis and MSCC? Sepsis is blood poisoning, which causes serious injuries if it is not diagnosed and treated as an emergency and may result in death if not treated quickly enough. MSCC is metastatic spinal cord compression, where the cancer presses on the spinal cord and can cause permanent paralysis. The investigators have chosen these two conditions, not only because of how serious and relatively common they are for people living with cancer, but also because all NHS Trusts in the UK routinely collect and report standardised data about patients who are admitted with suspected sepsis or MSCC. The investigators plan to compare data that is routinely collected about the diagnosis and treatment of patients with suspected sepsis and MSCC before and after education, training and assessment of staff about acute oncology. The investigators will conduct 'secondary analysis' on the data, as it was originally collected for another purpose. The routinely data collected at five hospital Trusts across the UK from 1st April 2023 to 30th June 2023 and 1st October to 31st December 2023 will be included in this study. This research is part of a larger UK-wide project, funded until March 2024 by NHS England Workforce, Training and Education Directorate. If acute oncology education, training and assessment of staff is shown to make a difference to patient diagnosis and treatment, the Acute Oncology Passports will be rolled-out nationally.

Conditions

Cancer

Outcome Measures

Primary Outcomes (1)

• Acute Oncology Key Performance Indicators (KPIs)

  These are routinely collected metrics by acute oncology teams for patients presenting with suspected neutropenic sepsis or metastatic spinal cord compression.

  1st April 2023- 31st December 2023

Study Arms (2)

Pre-Intervention

Retrospective data collection for pre-education intervention period: 1st April 2023- 1st June 2023

Other: Education, training and assessment intervention

Post-Intervention

Retrospective data collection for post-education intervention period: 1st October 2023- 31st December 2023

Other: Education, training and assessment intervention

Interventions

Education, training and assessment intervention OTHER

Staff competence assessment documents for acute oncology knowledge and skills

Post-Intervention; Pre-Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Cancer patients with suspected neutropenic sepsis or MSCC

You may qualify if:

• All patient KPI's of interest that occur in the study time frame will be collected.

You may not qualify if:

• KPI data collected from people under the age of 18 KPI data other than items stated in this application, i.e. data that is not reporting neutropenic sepsis nor MSCC outcomes

Sponsors & Collaborators

• The Christie NHS Foundation Trust: lead

MeSH Terms

Conditions

Neoplasms

Interventions

Educational Status

Intervention Hierarchy (Ancestors)

Socioeconomic Factors; Population Characteristics

Study Officials

• Clare Griffin, PhD

  The Christie NHS Foundation Trust

  STUDY DIRECTOR

Central Study Contacts

Verna TC Lavender, PhD

CONTACT

07773664761; Verna.Lavender@gstt.nhs.uk

Gina R Madera, BSc

CONTACT

07773664761; gina.madera@nhs.net

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 31, 2023
• First Posted: November 7, 2023
• Study Start: March 1, 2024
• Primary Completion: March 29, 2024
• Study Completion: March 29, 2024
• Last Updated: February 21, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share