REACT - Resistance Exercise After Cancer Treatment

NCT07159815 | Recruiting

• 1 other identifier: TR033
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Resistance exercise has been shown to improve several important health variables after cancer and cancer related treatment, but unfortunately the adherence to resistance exercise is low. Typical reported exercise barriers are inconvenient location (e.g. long distance from home), exercise at an unfavorable time of the day, inadequate access to cancer-specific exercise and insufficient recommendations from healthcare providers. Thus, there is need for more research on resistance exercise with an alternative approach in cancer rehabilitation, that potentially can target a broad range of patients, despite their domicile. In Norway, the foundation "Active against cancer" has established exercise locations tareting cancer patients in several hospitals, and today they also offer digital home-based exercise sessions. Therefore, the overall research objectives are to compare the efficacy of 12 weeks digital, home-based resistance exercise program on cancer patients after treatment on functional, mental, and metabolic health, compared to the same program conducted in a studio under guidance of an instructor. The primary aim is to compare the effect on exercise adherence between digital home-based exercise program and on-site guided program on cancer patients after treatment. Secondary aims are to compare the two groups on several functional health outcomes, mental health outcomes and metabolic health markers.

Conditions

Cancer

Outcome Measures

Primary Outcomes (1)

• Exercise adherence

  Percentage of completed prescribed exercise sessions.

  From baseline to pre-test (0-12 weeks)

Secondary Outcomes (19)

• Fatigue

  From baseline to pre-test (0-12 weeks)

• Quality of life

  From baseline to pre-test (0-12 weeks)

• Cancer related quality of life

  From baseline to pre-test (0-12 weeks)

• Depression

  From baseline to pre-test (0-12 weeks)

• Maximal muscle strength

  From baseline to pre-test (0-12 weeks)

Study Arms (2)

Digital home-based resistance exercise

EXPERIMENTAL

Participants in the digital group will need an e-mail and access to a pc and/or ipad at home. They will get access to a closed group on a digital platform, for participants in the project only. They will be asked to perform two pre-recorded resistance exercise sessions each week, for 12 weeks. Each session last for 40 minutes, and include 10 minutes of warm-up (ldynamic mobility and low impact), 25 minutes of resistance exercises (8-15 repetitions x 2-4 sets), and 5 minutes of cool-down and stretching. A total of 24 exercises will be performed over the period of 12 weeks.

Other: Digital follow-up; Behavioral: Resistance exercise

On-site resistance exercise

EXPERIMENTAL

Participants in the on-site group will be asked to participate in resistance exercise on-site with instructor, two times a week for 12 weeks. They will follow the exact same exercise program as the digital group. Participants living around the Gjøvik area will have their exercise sessions at The Inland hospital Gjøvik (with physiotherapist and instructor supervising/mentoring the students), and for participants living around Lillehammer the exercise will be held at a medical clinic (with physiotherapist and instructor supervising/mentoring the students). A total of 24 exercises will be performed over the period of 12 weeks.

Other: On-site follow-up; Behavioral: Resistance exercise

Interventions

Digital follow-up OTHER

See the arm/group description.

Also known as: Cancer rehabilitation, digital follow-up

Digital home-based resistance exercise

On-site follow-up OTHER

See the arm/group description.

Also known as: On-site cancer rehabilitation, on-site follow-up

On-site resistance exercise

Resistance exercise BEHAVIORAL

See the arm/group description.

Also known as: Cancer rehabilitation

Digital home-based resistance exercise; On-site resistance exercise

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ≥ 18 years and able to give informed consent
• Previously diagnosed with any form of cancer and completed systemic chemotherapy, immunotherapy or targeted therapies or local radiotherapy
• Have completed active cancer treatment not more than 12 months earlier or at present undergoing oral home-based treatment for stabilization or other treatments of disease or to prevent relapse
• Life expectancy of more than 12 months
• Digital opportunities at home: e.g axcess to pc, and/or ipad, email adress to log on the platform
• Able to understand Norwegian language

You may not qualify if:

• Co-morbidities prohibiting exercise according to protocol like serious cardic, pulmonary and other organ diseases
• Conditions caused by the cancer which prohibits exercise like previous major surgery, fractures, pain
• Still undergoing active cancer treatment that is expected to confer a high risk of bone marrow suppresion that would lead to infections, bleeding and/or severly reduced physical capacity
• Life expectancy of less than 12 months
• Reduced mental capacity and not able to give informed consent and follow the program
• Travelling distance more than 20 km from home or workplace to the two exercise locations (Gjøvik and/or Lillehammer) for patients who are candidates for randomization

Sponsors & Collaborators

• Inland Norway University of Applied Sciences: lead
• Sykehuset Innlandet HF: collaborator

Study Sites (1)

Inland Norway University of Applied Sciences

Lillehammer, Norway

RECRUITING

MeSH Terms

Conditions

Neoplasms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Anne Mette Rustaden, PhD

CONTACT

+47 48100644; anne.rustaden@inn.no

Stian Ellefsen, Professor

CONTACT

stian.ellefsen@inn.no

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Assessment of all the outcomes will be performed in a blinded fashion by assessors/investigators.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: The project is an assessor-blinded randomized controlled trial, where included participants will be randomized to either 12 weeks of digital home-based resistance exercise or the same program conducted in a studio under guidance of an instructor.

Study Record Dates

• First Submitted: August 15, 2023
• First Posted: September 8, 2025
• Study Start: August 1, 2023
• Primary Completion: January 1, 2026
• Study Completion (Estimated): June 30, 2028
• Last Updated: September 8, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

NO (1)